Thomas J. Waller
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View article: Axonal injury signaling is restrained by a spared synaptic branch
Axonal injury signaling is restrained by a spared synaptic branch Open
The intrinsic ability of injured neurons to degenerate and regenerate their axons facilitates nervous system repair; however, this ability is not engaged in all neurons and injury locations. Here, we investigate the regulation of a conserv…
View article: Pyruvate kinase deficiency links metabolic perturbations to neurodegeneration and axonal protection
Pyruvate kinase deficiency links metabolic perturbations to neurodegeneration and axonal protection Open
Neurons rely on tightly regulated metabolic networks to sustain their high-energy demands, particularly through the coupling of glycolysis and oxidative phosphorylation. Here, we investigate the role of pyruvate kinase (PyK), a key glycoly…
View article: Axonal injury signaling is restrained by a spared synaptic branch
Axonal injury signaling is restrained by a spared synaptic branch Open
The intrinsic ability of injured neurons to degenerate and regenerate their axons facilitates nervous system repair, however this ability is not engaged in all neurons and injury locations. Here we investigate the regulation of a conserved…
View article: Axonal injury signaling is restrained by a spared synaptic branch
Axonal injury signaling is restrained by a spared synaptic branch Open
The intrinsic ability of injured neurons to degenerate and regenerate their axons facilitates nervous system repair, however this ability is not engaged in all neurons and injury locations. Here we investigate the regulation of a conserved…
View article: Axonal injury signaling is restrained by a spared synaptic branch
Axonal injury signaling is restrained by a spared synaptic branch Open
The intrinsic ability of injured neurons to degenerate and regenerate their axons facilitates nervous system repair; however, this ability is not engaged in all neurons and injury locations. Here, we investigate the regulation of a conserv…
View article: Axonal injury signaling is restrained by a spared synaptic branch
Axonal injury signaling is restrained by a spared synaptic branch Open
The intrinsic ability of injured neurons to degenerate and regenerate their axons facilitates nervous system repair, however this ability is not engaged in all neurons and injury locations. Here we investigate the regulation of a conserved…
View article: Opposing roles of Fos, Raw, and SARM1 in the regulation of axonal degeneration and synaptic structure
Opposing roles of Fos, Raw, and SARM1 in the regulation of axonal degeneration and synaptic structure Open
Introduction The degeneration of injured axons is driven by conserved molecules, including the sterile armadillo TIR domain-containing protein SARM1, the cJun N-terminal kinase JNK, and regulators of these proteins. These molecules are als…
View article: Multifaceted roles of SARM1 in axon degeneration and signaling
Multifaceted roles of SARM1 in axon degeneration and signaling Open
Axons are considered to be particularly vulnerable components of the nervous system; impairments to a neuron’s axon leads to an effective silencing of a neuron’s ability to communicate with other cells. Nervous systems have therefore evolv…
View article: Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw
Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw Open
The degeneration of injured axons involves a self-destruction pathway whose components and mechanism are not fully understood. Here, we report a new regulator of axonal resilience. The transmembrane protein Raw is cell autonomously require…
View article: An <em>In Vitro</em> Assay to Detect tRNA-Isopentenyl Transferase Activity
An <em>In Vitro</em> Assay to Detect tRNA-Isopentenyl Transferase Activity Open
N6-isopentenyladenosine RNA modifications are functionally diverse and highly conserved among prokaryotes and eukaryotes. One of the most highly conserved N6-isopentenyladenosine modifications occurs at the A37 position in a subset of tRNA…
View article: Aggregation of Mod5 is affected by <scp>tRNA</scp> binding with implications for <scp>tRNA</scp> gene‐mediated silencing
Aggregation of Mod5 is affected by <span>tRNA</span> binding with implications for <span>tRNA</span> gene‐mediated silencing Open
Mod5 is a multifunctional protein that modifies a subset of tRNA s in the cytoplasm and is also required for an RNA ‐mediated form of transcriptional silencing. Previous in vivo studies have shown that the nuclear silencing function of Mod…