Thomas J. Walsh
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View article: Cost-effectiveness of olorofim in the treatment of invasive aspergillosis in patients with limited suitable alternative treatment options: a US payer perspective
Cost-effectiveness of olorofim in the treatment of invasive aspergillosis in patients with limited suitable alternative treatment options: a US payer perspective Open
This study aimed to estimate the cost-effectiveness of treating invasive aspergillosis (IA) in patients with limited treatment options with either olorofim or currently available antifungal salvage therapy from a US payer perspective. A hy…
View article: Commemorating the Landmark Advances in Our Understanding of Mucormycosis by Dimitrios P. Kontoyiannis
Commemorating the Landmark Advances in Our Understanding of Mucormycosis by Dimitrios P. Kontoyiannis Open
Writing with the perspective of a mentor, friend, and colleague, I am elated to contribute to this commemorative issue of the Journal of Fungi, which is dedicated to the landmark contributions of Dr. Dimitrios P. Kontoyiannis, who has grea…
View article: Potential predictive value of phylogenetic novelties in clinical fungi, illustrated by Histoplasma
Potential predictive value of phylogenetic novelties in clinical fungi, illustrated by Histoplasma Open
The phylogeny of the vertebrate pathogen Histoplasma capsulatum and its varieties was analyzed on the basis of GenBank data, comparing preceding papers that distinguished lineages on the basis of a much smaller dataset, partly dating back …
View article: Evaluating antimicrobial stewardship strategies in candidemia: a novel desirability of outcome ranking (DOOR) analysis comparing blood culture versus T2Candida diagnostic approaches
Evaluating antimicrobial stewardship strategies in candidemia: a novel desirability of outcome ranking (DOOR) analysis comparing blood culture versus T2Candida diagnostic approaches Open
The T2Candida Panel (T2 Biosystems, Lexington, MA) is a rapid diagnostic test that detects Candida from whole blood within 3–5 hours. We developed and applied a desirability of outcome ranking (DOOR) analysis to investigate if an antimicro…
View article: Advancing Patient Advocacy in Mycology: Cultivating Collaboration in Education, Research, and Policy
Advancing Patient Advocacy in Mycology: Cultivating Collaboration in Education, Research, and Policy Open
View article: Invasive Fungal Diseases of Combat Wounds: Burden, Epidemiology, and Mycology
Invasive Fungal Diseases of Combat Wounds: Burden, Epidemiology, and Mycology Open
View article: Nomenclature for human and animal fungal pathogens and diseases: a proposal for standardized terminology
Nomenclature for human and animal fungal pathogens and diseases: a proposal for standardized terminology Open
Medically important pathogenic fungi invade vertebrate tissue and are considered primary when part of their nature life cycle is associated with an animal host and are usually able to infect immunocompetent hosts. Opportunistic fungal path…
View article: Bacteriophage Treatment against Carbapenem-resistant<i>Klebsiella pneumoniae</i>(KPC) in a Neutropenic Murine Model of Gastrointestinal Translocation and Renal infection
Bacteriophage Treatment against Carbapenem-resistant<i>Klebsiella pneumoniae</i>(KPC) in a Neutropenic Murine Model of Gastrointestinal Translocation and Renal infection Open
Background Carbapenemase producing Klebsiella pneumoniae (KPC) are globally emerging pathogens which that cause life-threatening infections. Novel treatment alternatives are urgently needed. Methods We therefore investigated the effectiven…
View article: Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis
Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis Open
During pulmonary mucormycosis, inhaled sporangiospores adhere to, germinate, and invade airway epithelial cells to establish infection. We provide evidence that HIF1α plays dual roles in airway epithelial cells during Mucorales infection. …
View article: Development of a Combat-Relevant Murine Model of Wound Mucormycosis: A Platform for the Pre-Clinical Investigation of Novel Therapeutics for Wound-Invasive Fungal Diseases
Development of a Combat-Relevant Murine Model of Wound Mucormycosis: A Platform for the Pre-Clinical Investigation of Novel Therapeutics for Wound-Invasive Fungal Diseases Open
Wound-invasive fungal diseases (WIFDs), especially mucormycosis, have emerged as life-threatening infections during recent military combat operations. Many combat-relevant fungal pathogens are refractory to current antifungal therapy. Ther…
View article: Development of rabbit models of ventilator-associated bacterial pneumonia produced by carbapenem-resistant <i>Pseudomonas aeruginosa</i>
Development of rabbit models of ventilator-associated bacterial pneumonia produced by carbapenem-resistant <i>Pseudomonas aeruginosa</i> Open
Ventilator-associated bacterial pneumonia (VABP) is among the most intractable of carbapenem-resistant Gram-negative bacterial infections. New antimicrobial agents are critically needed for the treatment of VABP. However, current conventio…
View article: Shared Vision for Improving Outcomes for Serious Fungal Diseases: Report of a Patient, Caregiver, and Clinician Summit
Shared Vision for Improving Outcomes for Serious Fungal Diseases: Report of a Patient, Caregiver, and Clinician Summit Open
Background Recently, increasing focus on patient input into research and healthcare improvements has fostered expanded patient-centered advocacy efforts. This first pan-fungal disease summit, part of the MYCology Advocacy, Research, & Educ…
View article: Combination of Systemic and Lock-Therapies with Micafungin Eradicate Catheter-Based Biofilms and Infections Caused by Candida albicans and Candida parapsilosis in Neutropenic Rabbit Models
Combination of Systemic and Lock-Therapies with Micafungin Eradicate Catheter-Based Biofilms and Infections Caused by Candida albicans and Candida parapsilosis in Neutropenic Rabbit Models Open
Vascular catheter-related infections, primarily caused by Candida albicans and Candida parapsilosis, pose significant challenges due to the formation of biofilms on catheters, leading to refractory disease and considerable morbidity. We st…
View article: Reply to Kidd et al., “Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion”
Reply to Kidd et al., “Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion” Open
International audience
View article: Reply to Williams et al
Reply to Williams et al Open
In general, we agree with most of the comments raised by the authors and believe that they accurately illustrate a continuing problem of inadequate support for the use of mold-active triazoles (MATs) by insurance companies, plans, and/or p…
View article: 1700. Posaconazole-Induced Excess Mineralocorticoid Syndrome with Hypertension, Hypokalemia, and Inhibition of 11-b-hydroxylase in Pediatric Patients
1700. Posaconazole-Induced Excess Mineralocorticoid Syndrome with Hypertension, Hypokalemia, and Inhibition of 11-b-hydroxylase in Pediatric Patients Open
Background Posaconazole is a potent broad spectrum mould-active triazole that is increasingly used in children for treatment of aspergillosis, mucormycosis, and endemic mycoses. Although posaconazole has a favorable safety profile in pedia…
View article: A conceptual framework for nomenclatural stability and validity of medically important fungi: a proposed global consensus guideline for fungal name changes supported by ABP, ASM, CLSI, ECMM, ESCMID-EFISG, EUCAST-AFST, FDLC, IDSA, ISHAM, MMSA, and MSGERC
A conceptual framework for nomenclatural stability and validity of medically important fungi: a proposed global consensus guideline for fungal name changes supported by ABP, ASM, CLSI, ECMM, ESCMID-EFISG, EUCAST-AFST, FDLC, IDSA, ISHAM, MMSA, and MSGERC Open
The rapid pace of name changes of medically important fungi is creating challenges for clinical laboratories and clinicians involved in patient care. We describe two sources of name change which have different drivers, at the species versu…
View article: PLCG2-associated immune dysregulation (PLAID) comprises broad and distinct clinical presentations related to functional classes of genetic variants
PLCG2-associated immune dysregulation (PLAID) comprises broad and distinct clinical presentations related to functional classes of genetic variants Open
View article: Hyphae of Rhizopus arrhizus and Lichtheimia corymbifera Are More Virulent and Resistant to Antifungal Agents Than Sporangiospores In Vitro and in Galleria mellonella
Hyphae of Rhizopus arrhizus and Lichtheimia corymbifera Are More Virulent and Resistant to Antifungal Agents Than Sporangiospores In Vitro and in Galleria mellonella Open
Mucorales species cause debilitating, life-threatening sinopulmonary diseases in immunocompromised patients and penetrating wounds in trauma victims. Common antifungal agents against mucormycosis have significant toxicity and are often ine…
View article: A view of excellence for the future of medical mycology in Clinical Microbiology and Infection
A view of excellence for the future of medical mycology in Clinical Microbiology and Infection Open
Isaac Newton in 1665 wrote, “If I have seen further [than others], it is by standing on the shoulders of giants” [[1]Newton I. Letter from sir isaac Newton to Robert Hooke. Historical Society of Pennsylvania, 1675https://discover.hsp.org/R…
View article: Real-world Use of Mold-Active Triazole Prophylaxis in the Prevention of Invasive Fungal Diseases: Results From a Subgroup Analysis of a Multicenter National Registry
Real-world Use of Mold-Active Triazole Prophylaxis in the Prevention of Invasive Fungal Diseases: Results From a Subgroup Analysis of a Multicenter National Registry Open
Background Antifungal prophylaxis can prevent invasive fungal diseases (IFDs) in high-risk, immunocompromised patients. This study assessed the real-world use of mold-active triazoles (MATs) for the prevention of IFDs. Methods This subgrou…
View article: References
References Open
View article: Composing Efficient, Robust Tests for Policy Selection
Composing Efficient, Robust Tests for Policy Selection Open
Modern reinforcement learning systems produce many high-quality policies throughout the learning process. However, to choose which policy to actually deploy in the real world, they must be tested under an intractable number of environmenta…
View article: Food and Drug Administration Public Workshop Summary—Development Considerations of Antifungal Drugs to Address Unmet Medical Need
Food and Drug Administration Public Workshop Summary—Development Considerations of Antifungal Drugs to Address Unmet Medical Need Open
Pressing challenges in the treatment of invasive fungal infections (IFIs) include emerging and rare pathogens, resistant/refractory infections, and antifungal armamentarium limited by toxicity, drug-drug interactions, and lack of oral form…
View article: Non-Aspergillus Hyaline Molds: A Host-Based Perspective of Emerging Pathogenic Fungi Causing Sinopulmonary Diseases
Non-Aspergillus Hyaline Molds: A Host-Based Perspective of Emerging Pathogenic Fungi Causing Sinopulmonary Diseases Open
The incidence of invasive sino-pulmonary diseases due to non-Aspergillus hyaline molds is increasing due to an enlarging and evolving population of immunosuppressed hosts as well as improvements in the capabilities of molecular-based diagn…
View article: Development of a Corticosteroid-Immunosuppressed Mouse Model to Study the Pathogenesis and Therapy of Influenza-Associated Pulmonary Aspergillosis
Development of a Corticosteroid-Immunosuppressed Mouse Model to Study the Pathogenesis and Therapy of Influenza-Associated Pulmonary Aspergillosis Open
Influenza-associated pulmonary aspergillosis (IAPA) is a feared complication in patients with influenza tracheobronchitis, especially those receiving corticosteroids. Herein, we established a novel IAPA mouse model with low-inoculum Asperg…
View article: Approach to Patients with Suspected Fungal Diseases
Approach to Patients with Suspected Fungal Diseases Open
Fungal infections (mycoses) are increasing in incidence throughout the world as a result of modern medical practice and rise in the population of those at risk. Supporting this increase is the expanding use of immunosuppressive therapies, …
View article: Confirmation of Spodoptera frugiperda (Lepidoptera: Noctuidae) in Papua New Guinea by molecular diagnostics of mitochondrial DNA COI gene
Confirmation of Spodoptera frugiperda (Lepidoptera: Noctuidae) in Papua New Guinea by molecular diagnostics of mitochondrial DNA COI gene Open
Native to the Americas and the Caribbean, the highly invasive agricultural pest Spodoptera frugiperda (fall armyworm, FAW) gained global prominence in 2016 when its presence was confirmed in Nigeria and São Tomé and Principe.Since then, it…
View article: Meeting the Challenges of Sepsis in Severe Coronavirus Disease 2019: A Call to Arms
Meeting the Challenges of Sepsis in Severe Coronavirus Disease 2019: A Call to Arms Open
Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Sepsis may be caused by bacterial, fungal, or viral pathogens. The clinical manifestations exhibited by patients with severe corona…
View article: Osteoarticular Mycoses
Osteoarticular Mycoses Open
Osteoarticular mycoses are chronic debilitating infections that require extended courses of antifungal therapy and may warrant expert surgical intervention. As there has been no comprehensive review of these diseases, the International Con…