Thomas Jespersen
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View article: Magnetism and Nonlinear Charge Transport in NiFe <sub>2</sub> O <sub>4</sub> /γ‐Al <sub>2</sub> O <sub>3</sub> /SrTiO <sub>3</sub> Heterostructure: Toward Spintronic Applications
Magnetism and Nonlinear Charge Transport in NiFe <sub>2</sub> O <sub>4</sub> /γ‐Al <sub>2</sub> O <sub>3</sub> /SrTiO <sub>3</sub> Heterostructure: Toward Spintronic Applications Open
We present the synthesis and study of the magnetic and electronic properties of NiFe 2 O 4 /γ‐Al 2 O 3 /SrTiO 3 heterostructure. The γ‐Al 2 O 3 /SrTiO 3 interface hosts a high‐mobility 2D electron gas (2DEG) with large spin‐orbit coupling,…
View article: Metformin Protects Against Persistent Atrial Fibrillation in an Equine Model
Metformin Protects Against Persistent Atrial Fibrillation in an Equine Model Open
BACKGROUND: Horses are one of the few animals that spontaneously develop atrial fibrillation (AF), making them a powerful model for studying AF mechanisms and treatment effects. Despite the initial effectiveness of treatment in horses and …
View article: Magnetism and nonlinear charge transport in NiFe2O4/γ-Al2O3/SrTiO3 heterostructure for spintronic applications
Magnetism and nonlinear charge transport in NiFe2O4/γ-Al2O3/SrTiO3 heterostructure for spintronic applications Open
We present the synthesis and study of the magnetic and electronic properties of NiFe2O4/γ-Al2O3/SrTiO3 heterostructure. The γ-Al2O3/SrTiO3 interface hosts a high-mobility two-dimensional electron gas (2DEG) with large spin-orbit coupling, …
View article: $μ_\mathrm{2T}(n)$: A Method for Extracting the Density Dependent Mobility in Two-Terminal Nanodevices
$μ_\mathrm{2T}(n)$: A Method for Extracting the Density Dependent Mobility in Two-Terminal Nanodevices Open
Measuring carrier mobility as a function of the carrier density in semiconductors using Hall effect is the gold standard for quantifying scattering mechanisms. However, for nanostructures, the Hall effect is not applicable, and the density…
View article: Machine learning approach for automated localization of ventricular tachycardia ablation targets from substrate maps: development and validation in a porcine model
Machine learning approach for automated localization of ventricular tachycardia ablation targets from substrate maps: development and validation in a porcine model Open
Aims The recurrence rate of ventricular tachycardia (VT) after ablation remains high due to the difficulty in locating VT critical sites. This study proposes a machine learning approach for improved identification of ablation targets based…
View article: Differentiating mechanisms of long duration ventricular fibrillation in acute ischemic myocardium vs. chronic infarct in an in-vivo porcine model
Differentiating mechanisms of long duration ventricular fibrillation in acute ischemic myocardium vs. chronic infarct in an in-vivo porcine model Open
Background The substrate-specific mechanism of long duration ventricular fibrillation (LDVF) is poorly characterized. Mechanisms of initiation as well as maintenance of VF may vary between underlying substrates and warrant individualised t…
View article: Stiffness assessment of acute atrial lesions after radiofrequency and pulsed-field ablation using multifrequency magnetic resonance elastography
Stiffness assessment of acute atrial lesions after radiofrequency and pulsed-field ablation using multifrequency magnetic resonance elastography Open
Background Extensive catheter ablation beyond pulmonary vein isolation may acutely increase atrial tissue stiffness, however, this may differ between energy sources used. Objectives This study aimed to compare acute effects of radiofrequen…
View article: Detraining and the athlete's heart: evidence of reverse atrial remodeling in horses
Detraining and the athlete's heart: evidence of reverse atrial remodeling in horses Open
Introduction Despite their exceptional cardiovascular fitness, endurance athletes are paradoxically at a higher risk of developing atrial fibrillation (AF). This is attributed to exercise-induced heart remodeling, but it remains unknown wh…
View article: Diet and risk of atrial fibrillation: a systematic review
Diet and risk of atrial fibrillation: a systematic review Open
Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia. Comprehensive modification of established AF risk factors combined with dietary interventions and breaking deleterious habits has been shown to reduce AF burden a…
View article: TMPRSS6 cleaves KCNE1 and causes arrhythmias in iron overload disease
TMPRSS6 cleaves KCNE1 and causes arrhythmias in iron overload disease Open
Iron storage disease is associated with cardiovascular manifestations, including various forms of cardiac arrhythmias of unknown origin. In this study, cardiac arrhythmias associated with iron overload were investigated in human iPSC-deriv…
View article: Autonomic Nervous System: A Therapeutic Target for Cardiac End-Organ Damage in Hypertension
Autonomic Nervous System: A Therapeutic Target for Cardiac End-Organ Damage in Hypertension Open
More than 1.5 billion people worldwide have arterial hypertension. Hypertension increases the risks of death and cardiovascular disease, such as atrial fibrillation and heart failure. The autonomic nervous system plays an essential role in…
View article: Low-dose colchicine improves vasorelaxation, reduces arterial remodeling and attenuates blood pressure increases in spontaneously hypertensive rats
Low-dose colchicine improves vasorelaxation, reduces arterial remodeling and attenuates blood pressure increases in spontaneously hypertensive rats Open
Colchicine, a microtubule depolymerizing agent, is an effective therapy for the secondary prevention of cardiovascular disease and has been approved recently as a novel treatment for atherosclerosis associated with coronary artery disease.…
View article: Analysis of drug-induced and spontaneous cardioversions reveals similar patterns leading to termination of atrial fibrillation
Analysis of drug-induced and spontaneous cardioversions reveals similar patterns leading to termination of atrial fibrillation Open
Introduction The mechanisms leading to the conversion of atrial fibrillation (AF) to sinus rhythm are poorly understood. This study describes the dynamic behavior of electrophysiological parameters and conduction patterns leading to sponta…
View article: Targeting the NLRP3 inflammasome signalling for the management of atrial fibrillation
Targeting the NLRP3 inflammasome signalling for the management of atrial fibrillation Open
Inflammatory signalling via the nod‐like receptor (NLR) family pyrin domain‐containing protein‐3 (NLRP3) inflammasome has recently been implicated in the pathophysiology of atrial fibrillation (AF). However, the precise role of the NLRP3 i…
View article: Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node
Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node Open
Aims Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used to treat type 2 diabetes and obesity. Albeit cardiovascular outcomes generally improve, treatment with GLP-1 RAs is associated with increased heart rate, the …
View article: Catheter-based pulmonary vein isolation fails to prevent transient atrial arrhythmogenic changes related to acute obstructive respiratory events in a porcine model
Catheter-based pulmonary vein isolation fails to prevent transient atrial arrhythmogenic changes related to acute obstructive respiratory events in a porcine model Open
Aims Pulmonary vein isolation (PVI) is the corner stone of modern rhythm control strategies in patients with atrial fibrillation (AF). Sleep-disordered breathing (SDB) is prevalent in more than 50% of patients undergoing AF ablation, and s…
View article: Linking ablation curves with transmural lesions using a thoracoscopic bipolar biparietal irrigated radiofrequent clamp
Linking ablation curves with transmural lesions using a thoracoscopic bipolar biparietal irrigated radiofrequent clamp Open
Background The cornerstone of atrial fibrillation (AF) ablation is the achievement of long-lasting transmural lesions. However, it is currently unknown when transmurality is reached during ablation using the thoracoscopic bipolar biparieta…
View article: Muscarinic acetylcholine receptors M2 are upregulated in the atrioventricular nodal tract in horses with a high burden of second-degree atrioventricular block
Muscarinic acetylcholine receptors M2 are upregulated in the atrioventricular nodal tract in horses with a high burden of second-degree atrioventricular block Open
Background Second-degree atrioventricular (AV) block at rest is very common in horses. The underlying molecular mechanisms are unexplored, but commonly attributed to high vagal tone. Aim To assess whether AV block in horses is due to alter…
View article: Left atrial functional measurements’ utility in predicting long‐term risk of atrial fibrillation after isolated CABG
Left atrial functional measurements’ utility in predicting long‐term risk of atrial fibrillation after isolated CABG Open
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia following coronary artery bypass grafting (CABG). We hypothesized that measures of left atrial (LA) function would be useful in predicting AF in patients undergoing …
View article: O11 | In vitro and in vivo effects of dapagliflozin on adenosine diphosphate induced platelet aggregation response in Göttingen minipigs
O11 | In vitro and in vivo effects of dapagliflozin on adenosine diphosphate induced platelet aggregation response in Göttingen minipigs Open
Introduction: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) including dapagliflozin (DAPA) reduce cardiovascular morbidity and mortality in human patients with heart failure. The underlying mech-anisms of the beneficial cardiovascular…