Thomas K. Gaetjens
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View article: Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity Open
Immune cells have intensely physical lifestyles characterized by structural plasticity and force exertion. To investigate whether specific immune functions require stereotyped mechanical outputs, we used super-resolution traction force mic…
View article: Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse
Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse Open
Phagocytosis is a critical immune function for infection control and tissue homeostasis. During phagocytosis, pathogens are internalized and degraded in phagolysosomes. For pathogens that evade immune degradation, the prevailing view is th…
View article: Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse
Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse Open
Phagocytosis is a critical immune function for infection control and tissue homeostasis. This process is typically described as non-moving pathogens being internalized and degraded in phagolysosomes. For pathogens that evade immune degrada…
View article: Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis
Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis Open
Immune cells live intensely physical lifestyles characterized by structural plasticity, mechanosensitivity, and force exertion. Whether specific immune functions require stereotyped patterns of mechanical output, however, is largely unknow…
View article: Propulsive cell entry diverts pathogens from immune degradation by remodeling phagocytic synapse
Propulsive cell entry diverts pathogens from immune degradation by remodeling phagocytic synapse Open
Phagocytosis is a critical immune function for infection control and tissue homeostasis. This process is typically described as pathogens being internalized passively and degraded in phagolysosomes. For pathogens that evade immune degradat…