Thomas Kerkau
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View article: Cardioimmunologic response patterns after an acute heart failure event: Design and first results of AHF‐ImmunoCS
Cardioimmunologic response patterns after an acute heart failure event: Design and first results of AHF‐ImmunoCS Open
Aims We have previously shown that patients who develop heart‐reactive antibodies (HRAs) de novo after a heart failure (HF) hospitalization are at increased risk of adverse outcomes, lending weight to the hypothesis that B cells may play a…
View article: Prevalence of anti‐beta‐1 antibody 6 months after hospitalization for acute heart failure predicts adverse outcome
Prevalence of anti‐beta‐1 antibody 6 months after hospitalization for acute heart failure predicts adverse outcome Open
Aims Agonistic antibodies against neurohumoral receptors can induce cardio‐noxious effects by altering the baseline receptor activity. To estimate the prevalence of autoantibodies directed against the beta‐1 receptor (b1‐AAB) in patients a…
View article: Performance of Three SARS-CoV-2 Immunoassays, Three Rapid Lateral Flow Tests, and a Novel Bead-Based Affinity Surrogate Test for the Detection of SARS-CoV-2 Antibodies in Human Serum
Performance of Three SARS-CoV-2 Immunoassays, Three Rapid Lateral Flow Tests, and a Novel Bead-Based Affinity Surrogate Test for the Detection of SARS-CoV-2 Antibodies in Human Serum Open
For the control of immunity in COVID-19 survivors and vaccinated subjects, there is an urgent need for reliable and rapid serological assays. Based on samples from 63 COVID-19 survivors up to 7 months after symptom onset, and on 50 serum s…
View article: Adaptive anti‐myocardial immune response following hospitalization for acute heart failure
Adaptive anti‐myocardial immune response following hospitalization for acute heart failure Open
Aims It has been hypothesized that cardiac decompensation accompanying acute heart failure (AHF) episodes generates a pro‐inflammatory environment boosting an adaptive immune response against myocardial antigens, thus contributing to progr…
View article: Performance of three SARS-CoV-2 immunoassays, three rapid lateral flow tests and a novel bead-based affinity surrogate test for the detection of SARS-CoV-2 antibodies in human serum
Performance of three SARS-CoV-2 immunoassays, three rapid lateral flow tests and a novel bead-based affinity surrogate test for the detection of SARS-CoV-2 antibodies in human serum Open
For the control of immunity in COVID-19 survivors and vaccinated subjects there is an urgent need for reliable and rapid serological assays. Based on samples from 63 COVID-19 survivors up to seven months after symptom onset, and on 50 seru…
View article: Correction: Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction
Correction: Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction Open
[This corrects the article DOI: 10.1371/journal.pone.0227734.].
View article: Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction
Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction Open
Both conventional and regulatory CD4+ T-cells rely on costimulatory signals mediated by cell surface receptors including CD28 for full activation. We showed previously that stimulation of CD4+ Foxp3+ regulatory T-cells by superagonistic an…
View article: During acute graft versus host disease CD28 deletion in donor CD8<sup>+</sup>, but not CD4<sup>+</sup>, T cells maintain antileukemia responses in mice
During acute graft versus host disease CD28 deletion in donor CD8<sup>+</sup>, but not CD4<sup>+</sup>, T cells maintain antileukemia responses in mice Open
Donor lymphocyte infusions together with allogeneic hematopoietic stem cell transplantation are routinely used as second‐line treatment for hematological malignancies. Mature T cells in the graft crucially mediate a graft versus leukemia (…
View article: Cyclopeptide COR-1 to treat beta1-adrenergic receptor antibody-induced heart failure
Cyclopeptide COR-1 to treat beta1-adrenergic receptor antibody-induced heart failure Open
The second generation immunomodulating epitope-mimicking cyclopeptide COR-1 (also termed JNJ-5442840) offers promise to treat immune-mediated cardiac diseases.
View article: Accumulation of CD69+ tissue‑resident memory T cells in the nasal polyps of patients with chronic rhinosinusitis
Accumulation of CD69+ tissue‑resident memory T cells in the nasal polyps of patients with chronic rhinosinusitis Open
In patients with chronic rhinosinusitis with nasal polyps (CRSwNP), a relative accumulation of cluster of differentiation (CD)8+ T cells over CD4+ T cells occurs in nasal polyps compared with the peripheral blood. Nasal CD8+ T cells and CD…
View article: Impact and Modulations of Peripheral and Edaphic B Cell Subpopulations in Chronic Rhinosinusitis With Nasal Polyposis
Impact and Modulations of Peripheral and Edaphic B Cell Subpopulations in Chronic Rhinosinusitis With Nasal Polyposis Open
In this study a detailed contemporary characterization of B cell subpopulations in patients with CRSwNP is presented. The influence of edaphic B cells could play a key role in the maintenance of this chronic infectious disease.
View article: Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4+ Foxp3+ Regulatory T Cells
Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4+ Foxp3+ Regulatory T Cells Open
Acute graft-versus-host disease (aGvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell plus T cell transplantation (allo-HSCT). In this study, we investigated the requirement for CD28 co-stimulation of…
View article: Myocardial aging as a T-cell–mediated phenomenon
Myocardial aging as a T-cell–mediated phenomenon Open
Significance Aging is a risk factor for heart diseases, and it is also known to impact on several immunological processes. Nevertheless, most studies addressing the cardio-immune cross-talk have focused on juvenile rather than senescent an…
View article: Characterization of T-cell Subpopulations in Patients with Chronic Rhinosinusitis with Nasal Polyposis
Characterization of T-cell Subpopulations in Patients with Chronic Rhinosinusitis with Nasal Polyposis Open
Background There is an ongoing discussion concerning the potential origins of chronic rhinosinusitis with nasal polyposis (CRSwNP). Objective The aim of this study was to quantify subpopulations of T cells in peripheral blood and nasal pol…
View article: Hsp90 inhibition ameliorates CD4<sup>+</sup> T cell‐mediated acute Graft versus Host disease in mice
Hsp90 inhibition ameliorates CD4<sup>+</sup> T cell‐mediated acute Graft versus Host disease in mice Open
Introduction For many patients with leukemia only allogeneic bone marrow transplantion provides a chance of cure. Co‐transplanted mature donor T cells mediate the desired Graft versus Tumor (GvT) effect required to destroy residual leukemi…
View article: Characterisation of stimulating rat anti-β1EC2.
Characterisation of stimulating rat anti-β1EC2. Open
(A) ELISA-reactivity (mean±SEM) of n = 6 representative rat anti- β1EC2 (1:5000, 12h, 4°C) with linear (dark green) or cyclic β1EC2-peptides (light green); p<0.005 (Student’s t-test). (B) Blocking capacity of linear β1EC2- or cyclic β1- an…
View article: Morphometric analysis of rat hearts (therapy-study).
Morphometric analysis of rat hearts (therapy-study). Open
Morphometric data of rat hearts harvested at the end of the therapy-study were obtained by computer-aided analysis of H&E-stained; mid-ventricular 2 μm cross-sections as previously described in detail [18]. Parameters given are (from top t…
View article: Immunology of cyclic β1EC2-peptides: fate of β1EC2-specific T- and B-cells.
Immunology of cyclic β1EC2-peptides: fate of β1EC2-specific T- and B-cells. Open
(A) Titer-course of anti-β1EC2-abs in β1EC2-CP-treated rats during the first 6 months of the prevention-study before and 24h after cyclopeptide-injection. Time-points of antigen-boosts are indicated by (red) lines, time-points of CP-inject…
View article: CD28 co-stimulation in T-cell homeostasis: a recent perspective
CD28 co-stimulation in T-cell homeostasis: a recent perspective Open
T-cells play a key role within the adaptive immune system mediating cellular immunity and orchestrating the immune response as a whole. Their activation requires not only recognition of antigen/major histocompatibility complexes by the T-c…
View article: In vitro polyclonal activation of conventional T cells with a CD28 superagonist protects mice from acute graft versus host disease
In vitro polyclonal activation of conventional T cells with a CD28 superagonist protects mice from acute graft versus host disease Open
Upon transplantation of T cells from a CD28 superagonist (CD28‐SA) treated donor into an irradiated allogeneic host, the CD28‐SA‐induced activation and expansion of T reg cells inhibits acute graft versus host disease (aGvHD), while not ab…
View article: Novel Receptor-Derived Cyclopeptides to Treat Heart Failure Caused by Anti-β1-Adrenoceptor Antibodies in a Human-Analogous Rat Model
Novel Receptor-Derived Cyclopeptides to Treat Heart Failure Caused by Anti-β1-Adrenoceptor Antibodies in a Human-Analogous Rat Model Open
Despite recent therapeutic advances the prognosis of heart failure remains poor. Recent research suggests that heart failure is a heterogeneous syndrome and that many patients have stimulating auto-antibodies directed against the second ex…