Thomas Kvistgaard Vilhelmsen
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View article: In-line monitoring of tablet compression with terahertz time-domain spectroscopy for physical tablet characteristics
In-line monitoring of tablet compression with terahertz time-domain spectroscopy for physical tablet characteristics Open
Process analysers integrated in process analytical technology (PAT) systems are now well-established in the pharmaceutical industry. These sensors play a crucial role in advancing manufacturing science by enabling robust process designs al…
View article: Using density changes to monitor blending with magnesium stearate by terahertz time-domain spectroscopy
Using density changes to monitor blending with magnesium stearate by terahertz time-domain spectroscopy Open
Magnesium stearate (MgSt) is among the most common excipients and the most common lubricant in solid oral products. It is primarily added to tablet formulations to ease ejection during tablet compression. While commonly present in low conc…
View article: THz-TDS as a PAT tool for monitoring blend homogeneity in pharmaceutical manufacturing of solid oral dosage forms: A proof-of-concept study
THz-TDS as a PAT tool for monitoring blend homogeneity in pharmaceutical manufacturing of solid oral dosage forms: A proof-of-concept study Open
The process analytical technology (PAT) framework is well established and integral to facilitate process understanding, enable a transition from batch to continuous manufacturing, and improve product quality. Near-infrared (NIR) spectrosco…
View article: Data supporting the manuscript 'Effect of particle size and deformation behaviour on water ingress into tablets'
Data supporting the manuscript 'Effect of particle size and deformation behaviour on water ingress into tablets' Open
Raw data for Figures 1, 3-8 in 'Effect of particle size and deformation behaviour on water ingress into tablets' (International Journal of Pharmaceutics, volume 587, 2020).
View article: The relevance of granule fragmentation on reduced tabletability of granules from ductile or brittle materials produced by roll compaction/dry granulation
The relevance of granule fragmentation on reduced tabletability of granules from ductile or brittle materials produced by roll compaction/dry granulation Open
Roll compaction/dry granulation often results in loss of tabletability. The two main hypotheses for this are granule hardening and granule size enlargement. The aim of this study was to investigate the effect of granule size, roll compacti…