Thomas L. Diepgen
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View article: S3 guideline „actinic keratosis and cutaneous squamous cell carcinoma“ – update 2023, part 2: epidemiology and etiology, diagnostics, surgical and systemic treatment of cutaneous squamous cell carcinoma (cSCC), surveillance and prevention
S3 guideline „actinic keratosis and cutaneous squamous cell carcinoma“ – update 2023, part 2: epidemiology and etiology, diagnostics, surgical and systemic treatment of cutaneous squamous cell carcinoma (cSCC), surveillance and prevention Open
Summary Actinic keratosis (AK) are common lesions in light‐skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major d…
View article: S3‐Leitlinie “Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Update 2023, Teil 1: Therapie der aktinischen Keratose, Morbus Bowen, Cheilitis actinica, berufsbedingte Erkrankung und Versorgungsstrukturen
S3‐Leitlinie “Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Update 2023, Teil 1: Therapie der aktinischen Keratose, Morbus Bowen, Cheilitis actinica, berufsbedingte Erkrankung und Versorgungsstrukturen Open
Zusammenfassung Aktinische Keratosen (AK) sind häufige Hautveränderungen bei hellhäutigen Menschen mit dem Potenzial, in ein kutanes Plattenepithelkarzinom (PEK) überzugehen. Beide Erkrankungen können mit erheblicher Morbidität verbunden s…
View article: S3 guideline „actinic keratosis and cutaneous squamous cell carcinoma“– update 2023, part 1: treatment of actinic keratosis, actinic cheilitis, cutaneous squamous cell carcinoma in situ (Bowen's disease), occupational disease and structures of care
S3 guideline „actinic keratosis and cutaneous squamous cell carcinoma“– update 2023, part 1: treatment of actinic keratosis, actinic cheilitis, cutaneous squamous cell carcinoma in situ (Bowen's disease), occupational disease and structures of care Open
Summary Actinic keratosis (AK) are common lesions in light‐skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major d…
View article: German S3 guideline “actinic keratosis and cutaneous squamous cell carcinoma” – Long version of the update 2023
German S3 guideline “actinic keratosis and cutaneous squamous cell carcinoma” – Long version of the update 2023 Open
Actinic keratosis (AK) are common lesions in light-skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major disease b…
View article: Causes of irritant contact dermatitis after occupational skin exposure: a systematic review
Causes of irritant contact dermatitis after occupational skin exposure: a systematic review Open
View article: Aktualisierung„ Systemtherapie bei Neurodermitis“ zur S2k‐Leitlinie Neurodermitis
Aktualisierung„ Systemtherapie bei Neurodermitis“ zur S2k‐Leitlinie Neurodermitis Open
Zusammenfassung Die vorliegende Leitlinie ist eine Aktualisierung vom August 2020 zu Systemtherapeutika der 2015 publizierten AWMF‐S2k‐Leitlinie Neurodermitis. Anlass für die Aktualisierung dieses Kapitels der Leitlinie waren die aktuellen…
View article: Assessment of the effects of a work-related allergy to seafood on the reduction of earning capacity in the context of BK No. 5101
Assessment of the effects of a work-related allergy to seafood on the reduction of earning capacity in the context of BK No. 5101 Open
Fish, crustaceans, and mollusks are among the most potent allergenic foods of animal origin and are thus important triggers of work-related immediate-food allergies. In Germany, work-related seafood allergies are of great importance in the…
View article: Update “Systemic treatment of atopic dermatitis” of the S2k‐guideline on atopic dermatitis
Update “Systemic treatment of atopic dermatitis” of the S2k‐guideline on atopic dermatitis Open
Summary This guideline is an update from August 2020 the S2k‐guideline “Atopic dermatitis” published in 2015. The reason for updating this chapter of the guideline were the current developments in the field of systemic therapy of atopic de…
View article: Basal cell carcinoma risk and solar UV exposure in occupationally relevant anatomic sites: do histological subtype, tumor localization and Fitzpatrick phototype play a role? A population-based case-control study
Basal cell carcinoma risk and solar UV exposure in occupationally relevant anatomic sites: do histological subtype, tumor localization and Fitzpatrick phototype play a role? A population-based case-control study Open
View article: APPLES Study Sites
APPLES Study Sites Open
The 314 study sites in Europe and North America that enrolled patients in the APPLES study are listed here by country.
View article: Contact Allergy to Fragrance Mix II and Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde: A Retrospective Study by International Contact Dermatitis Research Group
Contact Allergy to Fragrance Mix II and Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde: A Retrospective Study by International Contact Dermatitis Research Group Open
The frequency of missed contact allergy to HICC when testing only with FM II was less than 0.5%, therefore questioning the need to test HICC separately in the ICDRG baseline series.
View article: S3‐Leitlinie „Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Kurzfassung, Teil 2: Epidemiologie, chirurgische und systemische Therapie des Plattenepithelkarzinoms, Nachsorge, Prävention und Berufskrankheit
S3‐Leitlinie „Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Kurzfassung, Teil 2: Epidemiologie, chirurgische und systemische Therapie des Plattenepithelkarzinoms, Nachsorge, Prävention und Berufskrankheit Open
Zusammenfassung Aktinische Keratosen (AK) sind häufige Hautveränderungen bei hellhäutigen Menschen mit dem Potenzial, in ein kutanes Plattenepithelkarzinom (PEK) überzugehen. Beide Erkrankungen können mit erheblicher Morbidität verbunden s…
View article: S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma (cSCC) – short version, part 2: epidemiology, surgical and systemic treatment of cSCC, follow‐up, prevention and occupational disease
S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma (cSCC) – short version, part 2: epidemiology, surgical and systemic treatment of cSCC, follow‐up, prevention and occupational disease Open
Summary Actinic keratoses (AKs) are common lesions in light‐skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major …
View article: S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma – short version, part 1: diagnosis, interventions for actinic keratoses, care structures and quality‐of‐care indicators
S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma – short version, part 1: diagnosis, interventions for actinic keratoses, care structures and quality‐of‐care indicators Open
Summary Actinic keratoses (AK) are common lesions in light‐skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major d…
View article: S3‐Leitlinie „Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Kurzfassung, Teil 1: Diagnostik, Interventionen bei aktinischen Keratosen, Versorgungsstrukturen und Qualitätsindikatoren
S3‐Leitlinie „Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Kurzfassung, Teil 1: Diagnostik, Interventionen bei aktinischen Keratosen, Versorgungsstrukturen und Qualitätsindikatoren Open
Zusammenfassung Aktinische Keratosen (AK) sind häufige Hautveränderungen bei hellhäutigen Menschen mit dem Potenzial, in ein kutanes Plattenepithelkarzinom (PEK) überzugehen. Beide Erkrankungen können mit erheblicher Morbidität verbunden s…
View article: Development of a Conceptual Model of Chronic Hand Eczema (CHE) Based on Qualitative Interviews with Patients and Expert Dermatologists
Development of a Conceptual Model of Chronic Hand Eczema (CHE) Based on Qualitative Interviews with Patients and Expert Dermatologists Open
Findings from this literature review and in-depth qualitative interviews supported the development of a comprehensive conceptual model documenting the signs, symptoms and impacts relevant to CHE patients. Such a model is of considerable va…
View article: Revised Baseline Series of the International Contact Research Group
Revised Baseline Series of the International Contact Research Group Open
To the Editor: To develop international comparative data, the International Contact Dermatitis Research Group (ICDRG) created a standard series in 1997 composed of 20 haptens. This series was expanded to contain 32 haptens in 2011,1which s…
View article: Photoprotection and vitamin D status
Photoprotection and vitamin D status Open
Vitamin D is produced by the skin in response to ultraviolet radiation (UVR) from sunlight. A lack of vitamin D, known as vitamin D deficiency, can cause bones to become soft and weak, which can lead to bone deformities. Whilst UVR exposur…
View article: The epidemic of methylisothiazolinone contact allergy in Europe: follow‐up on changing exposures
The epidemic of methylisothiazolinone contact allergy in Europe: follow‐up on changing exposures Open
Background Methylisothiazolinone (MI) has caused an unprecedented epidemic of contact allergy in Europe and elsewhere. Subsequently, regulatory action has been taken, at least in Europe, aiming at reducing risk of MI sensitization. Objecti…
View article: Validation of a questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix I
Validation of a questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix I Open
The algorithm used in this study was not substantiated in this ROAT set-up. The stronger the patch test reactivity the more likely was a positive ROAT and the more likely it was that the positive ROAT appeared early during the application …
View article: Sunscreen photoprotection and vitamin D status
Sunscreen photoprotection and vitamin D status Open
Sunscreen use for daily and recreational photoprotection does not compromise vitamin D synthesis, even when applied under optimal conditions. What's already known about this topic? Knowledge of the relationship between solar exposure behav…
View article: Interventions for hand eczema
Interventions for hand eczema Open
Most findings were from single studies with low precision, so they should be interpreted with caution. Topical corticosteroids and UV phototherapy were two of the major standard treatments, but evidence is insufficient to support one speci…
View article: The significance of batch and patch test method in establishing contact allergy to fragrance mix I—EDEN Fragrance Study Group
The significance of batch and patch test method in establishing contact allergy to fragrance mix I—EDEN Fragrance Study Group Open
Background A fragrance mix consisting of eight separate fragrance ingredients (fragrance mix I [FM I]) is present in most baseline patch test series. Patch testing with the TRUE Test technique is considered to detect less contact allergy t…
View article: Socioeconomic Status and the Prevalence of Skin and Atopic Diseases in Five European Countries
Socioeconomic Status and the Prevalence of Skin and Atopic Diseases in Five European Countries Open
The aim of this study was to investigate the association between socioeconomic status and the prevalence of self-reported skin and atopic diseases in the general population of 5 European countries. A random sample was drawn from the genera…
View article: Allergy Alert Test for p-Phenylenediamine–Allergic Hair Dye Users
Allergy Alert Test for p-Phenylenediamine–Allergic Hair Dye Users Open
The AAT caused a reaction self-noticeable on the forearm in 90.5% (38/42) and behind the ear in 93% (39/42) of the PPD-positive subjects. This was objectified by a dermatological evaluation. The strength of the AAT response and the number …
View article: Positionspapier: Telemedizin in der Berufsdermatologie – Aktueller Stand und Perspektiven
Positionspapier: Telemedizin in der Berufsdermatologie – Aktueller Stand und Perspektiven Open
Zusammenfassung Die Teledermatologie ist die Verwendung von Telekommunikationstechnologien zum Austausch medizinischer Informationen für Diagnostik, Konsultation, Therapie und Lehre in der Dermatologie. Während ihr Einsatz bei einem breite…
View article: Position paper: Telemedicine in occupational dermatology – current status and perspectives
Position paper: Telemedicine in occupational dermatology – current status and perspectives Open
Summary Teledermatology is the use of telecommunication technologies to exchange medical information for diagnosis, consultation, treatment and teaching in dermatology. While its use has been evaluated in a wide range of dermatological dia…
View article: Prevalence of contact allergy to metals in the European general population with a focus on nickel and piercings: The EDEN Fragrance Study
Prevalence of contact allergy to metals in the European general population with a focus on nickel and piercings: The EDEN Fragrance Study Open
Background Studies on sensitization to metals in the general population are scarce. Objectives To determine the prevalence of sensitization to metals in the general population, and factors associated with nickel sensitization. Methods In 5…
View article: 在工作中遭受的紫外线照射是否是皮肤鳞状细胞癌最重要的风险因素?基于人群的病例对照研究FB-181的结果
在工作中遭受的紫外线照射是否是皮肤鳞状细胞癌最重要的风险因素?基于人群的病例对照研究FB-181的结果 Open
鳞状细胞癌(SCC)是一种特定形式的皮肤癌,也是欧洲最常见的癌症之一。因此,SCC对患者本身以及在社会代价方面都造成了极大的负担。SCC的一个主要原因是暴露在自然阳光下,因此可以通过避免过度曝晒来预防SCC。外出时,人们可以利用衣物(例如长袖、帽子)和防晒霜来保护皮肤。到目前为止,SCC和其他皮肤癌的预防计划主要是尝试减少在休闲时间中的过度曝晒。然而,有许多人是在室外工作的,例如农民、建筑工人和屋顶工。职业(与工作相关)和休闲时间的阳光曝晒在导致SCC中所起的作用仍不明确。…
View article: Commentary on the “Evidence- and Consensus-Based (S3) Guidelines for the Treatment of Actinic Keratosis” Published by the International League of Dermatological Societies in Cooperation with the European Dermatology Forum
Commentary on the “Evidence- and Consensus-Based (S3) Guidelines for the Treatment of Actinic Keratosis” Published by the International League of Dermatological Societies in Cooperation with the European Dermatology Forum Open
In 2015, the International League of Dermatological Societies and the European Dermatology Forum published a guideline for the treatment of actinic keratosis, which is classified as an evidence- and consensus-based S3 guideline. From the p…