Thomas M. Link
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View article: Functionalisation of PTCDA to PDI derivatives: impact on optical and fundamental bandgap, solubility, and electronic structure
Functionalisation of PTCDA to PDI derivatives: impact on optical and fundamental bandgap, solubility, and electronic structure Open
The transformation of 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) to perylene diimide (PDI) and further derivatives offers a promising strategy to tailor the solubility and electronic properties of organic semiconductors for optoe…
View article: Association between constant and intermittent knee pain and T2 values and cartilage thickness: data from the osteoarthritis initiative
Association between constant and intermittent knee pain and T2 values and cartilage thickness: data from the osteoarthritis initiative Open
Background We investigated whether cartilage composition and thickness and its change over time were associated with future intermittent and constant knee pain. Methods Osteoarthritis Initiative participants with 3T MRI scans from baseline…
View article: Relationship Between Early Cartilage Degeneration With T1ρ and T2 Analysis in Medial Tibial Cartilage and 10-Year Posttraumatic Osteoarthritis Progression After ACL Reconstruction
Relationship Between Early Cartilage Degeneration With T1ρ and T2 Analysis in Medial Tibial Cartilage and 10-Year Posttraumatic Osteoarthritis Progression After ACL Reconstruction Open
Background: Quantitative magnetic resonance imaging (qMRI), such as T1ρ and T2 mapping, allows for the characterization of the biochemical composition of cartilage and the detection of early degeneration within 1 year after anterior crucia…
View article: Ab Initio Calculation of Energy Gap and Optical Gap of Organic Semiconductors PTCDA and PDI
Ab Initio Calculation of Energy Gap and Optical Gap of Organic Semiconductors PTCDA and PDI Open
We applied ab initio methods, including the GW approximation, the Koopmans functionals, range- separated hybrid functionals, and time-dependent density functional theory (TDDFT) to investigate the energy gap and optical gap of perylene-3,4…
View article: Prognostic Factors on Preoperative MRI for Patient-Reported Outcomes After Posterior Medial Meniscus Root Repair
Prognostic Factors on Preoperative MRI for Patient-Reported Outcomes After Posterior Medial Meniscus Root Repair Open
Background: Repair of posterior medial meniscus root (PMMR) tears has demonstrated favorable outcomes and may prevent rapid progression of knee osteoarthritis; however, there is a paucity of data regarding prognostic factors affecting post…
View article: Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis
Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis Open
Objective Our objective was to investigate the overall and sex‐specific relationships between the presence and severity of knee osteoarthritis (KOA) and muscle composition, power, and energetics in older adults. Methods Male and female pat…
View article: Cartilage compositional MRI—a narrative review of technical development and clinical applications over the past three decades
Cartilage compositional MRI—a narrative review of technical development and clinical applications over the past three decades Open
Articular cartilage damage and degeneration are among hallmark manifestations of joint injuries and arthritis, classically osteoarthritis. Cartilage compositional MRI (Cart-C MRI), a quantitative technique, which aims to detect early-stage…
View article: Clinical and imaging findings associated with preservation of knee joint health over 8 years in individuals aged 65 and over: data from the OAI
Clinical and imaging findings associated with preservation of knee joint health over 8 years in individuals aged 65 and over: data from the OAI Open
Objective While risk factors for osteoarthritis (OA) are well known, it is not well understood why certain individuals maintain high mobility and joint health throughout their life while others demonstrate OA at older ages. The purpose of …
View article: Associations of cumulative voriconazole dose, treatment duration, and alkaline phosphatase with voriconazole-induced periostitis
Associations of cumulative voriconazole dose, treatment duration, and alkaline phosphatase with voriconazole-induced periostitis Open
Objective To investigate the associations of cumulative voriconazole dose, treatment duration, and alkaline phosphatase with voriconazole-induced periostitis. Materials and methods One hundred and thirty-one patients with voriconazole use …
View article: Association between hip muscle strength/function and hip cartilage defects in sub-elite football players with hip/groin pain
Association between hip muscle strength/function and hip cartilage defects in sub-elite football players with hip/groin pain Open
Overall, there were few associations between peak isometric hip muscle strength and overall hip cartilage defects. It is possible that other factors may have relevance in sub-elite football players. Additional studies are needed to support…
View article: Clinical and radiologic outcomes in patients with meniscal root tears
Clinical and radiologic outcomes in patients with meniscal root tears Open
Background Meniscal root tears can lead to early knee osteoarthritis and pain. This study aimed (1) to compare clinical and radiological outcomes between patients who underwent arthroscopic meniscal root repair after meniscal root tears an…
View article: Microvascular disease not type 2 diabetes is associated with increased cortical porosity: A study of cortical bone microstructure and intracortical vessel characteristics
Microvascular disease not type 2 diabetes is associated with increased cortical porosity: A study of cortical bone microstructure and intracortical vessel characteristics Open
The presence of MVD, rather than T2D, was associated with increased cortical porosity. Increased porosity in MVD was coupled with a larger number of smaller vessels, which could indicate upregulation of neovascularization triggered by isch…
View article: Can conventional magnetic resonance imaging at presentation predict chemoresistance in osteosarcoma?
Can conventional magnetic resonance imaging at presentation predict chemoresistance in osteosarcoma? Open
Objectives Histological tumour necrosis is the current indicator for the response of osteosarcoma after neoadjuvant chemotherapy. Chemoresistant tumours require close monitoring and adjustment of treatment. Characteristics of tumours on ba…
View article: Diabetes Risk Factors and Bone Microarchitecture as Assessed by High-Resolution Peripheral Quantitative Computed Tomography in Adults With Long-standing Type 1 Diabetes
Diabetes Risk Factors and Bone Microarchitecture as Assessed by High-Resolution Peripheral Quantitative Computed Tomography in Adults With Long-standing Type 1 Diabetes Open
OBJECTIVE To determine whether type 1 diabetes and its complications are associated with bone geometry and microarchitecture. RESEARCH DESIGN AND METHODS This cross-sectional study was embedded in a long-term observational study. High-reso…
View article: Bone Marrow Adiposity Alterations in Type 2 Diabetes Are Sex-Specific and Associated with Serum Lipid Levels
Bone Marrow Adiposity Alterations in Type 2 Diabetes Are Sex-Specific and Associated with Serum Lipid Levels Open
Type 2 diabetes (T2D) has negative effects on skeletal health. A proposed mechanism of diabetic bone disease connects hyperlipidemia to increased bone marrow adiposity and decreased bone quality. Previous research on Type 1 diabetes report…
View article: THE ROLE OF MRI IN OSTEOARTHRITIS CLINICAL TRIAL IMAGING: A POLL OF ATTENDEES AT THE OARSI 2023 IMAGING DISCUSSION GROUP SESSION
THE ROLE OF MRI IN OSTEOARTHRITIS CLINICAL TRIAL IMAGING: A POLL OF ATTENDEES AT THE OARSI 2023 IMAGING DISCUSSION GROUP SESSION Open
MRI is now being adopted into roles of patient screening, selection, and outcome assessment in OA clinical trials, yet there are still barriers to universal implementation. Engagement with the OA research community and pharmaceutical indus…
View article: Does Femoroacetabular Impingement Syndrome Affect Self-Reported Burden in Football Players With Hip and Groin Pain?
Does Femoroacetabular Impingement Syndrome Affect Self-Reported Burden in Football Players With Hip and Groin Pain? Open
Background: It is unknown if football players with femoroacetabular impingement (FAI) syndrome report worse burden than those with other causes of hip/groin pain, and to what extent this is mediated by cartilage defects and labral tears. H…
View article: Paraspinal Muscle in Chronic Low Back Pain: Comparison Between Standard Parameters and Chemical Shift Encoding‐Based Water–Fat <scp>MRI</scp>
Paraspinal Muscle in Chronic Low Back Pain: Comparison Between Standard Parameters and Chemical Shift Encoding‐Based Water–Fat <span>MRI</span> Open
Background Paraspinal musculature (PSM) is increasingly recognized as a contributor to low back pain (LBP), but with conventional MRI sequences, assessment is limited. Chemical shift encoding‐based water–fat MRI (CSE‐MRI) enables the measu…
View article: Effects of Weight Change on Knee and Hip Radiographic Measurements and Pain Over Four Years: Data From the Osteoarthritis Initiative
Effects of Weight Change on Knee and Hip Radiographic Measurements and Pain Over Four Years: Data From the Osteoarthritis Initiative Open
Objective To assess the effects of weight loss and weight gain on hip and knee radiographic changes, pain, and joint replacement over 4 years. Methods Participants (n = 2,752) from the Osteoarthritis Initiative were classified as those wit…