Thomas Linsenmann
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View article: Combined Frameless Stereotactical Biopsy and Intraoperative Cerebral Angiography by 3D-Rotational Fluoroscopy with Intravenous Contrast Administration. A Feasibility Study.
Combined Frameless Stereotactical Biopsy and Intraoperative Cerebral Angiography by 3D-Rotational Fluoroscopy with Intravenous Contrast Administration. A Feasibility Study. Open
Purpose: Mobile 3-dimensional fluoroscopes are available in a number of neurosurgical departments and can be used in combination with simple image post processing to depict cerebral vessels. In preparation of stereotactic surgery, preopera…
View article: Optimization of radiation settings for angiography using 3D fluoroscopy for imaging of intracranial aneurysms
Optimization of radiation settings for angiography using 3D fluoroscopy for imaging of intracranial aneurysms Open
Mobile 3D fluoroscopes have become increasingly available in neurosurgical operating rooms. We recently reported its use for imaging cerebral vascular malformations and aneurysms. This study was conducted to evaluate various radiation sett…
View article: Complete radiological response following subtotal resection in three glioblastoma patients under treatment with Tumor Treating Fields
Complete radiological response following subtotal resection in three glioblastoma patients under treatment with Tumor Treating Fields Open
Glioblastoma multiforme (GBM) treatment consists of surgery, radiotherapy and chemotherapy with Temozolomide (TMZ). After subtotal resection (STR), residual tumors rarely undergo spontaneous regression. Overall survival (OS) and progressio…
View article: ACTR-19. REPORT ON THE COMBINATION OF AXITINIB AND TUMOR TREATING FIELDS (TTFIELDS) IN THREE PATIENTS WITH RECURRENT GLIOBLASTOMA
ACTR-19. REPORT ON THE COMBINATION OF AXITINIB AND TUMOR TREATING FIELDS (TTFIELDS) IN THREE PATIENTS WITH RECURRENT GLIOBLASTOMA Open
OBJECTIVE Tumor Treating Fields (TTFields) significantly improved survival of newly diagnosed glioblastoma (ndGBM) patients in the EF-14 trial. Axitinib is an orally available tyrosine kinase inhibitor which is approved for the treatment o…
View article: P14.60 FET PET response upon radiochemotherapy followed by Tumor Treating Fields (TTFields) in a patient with progressive high-grade glioma
P14.60 FET PET response upon radiochemotherapy followed by Tumor Treating Fields (TTFields) in a patient with progressive high-grade glioma Open
BACKGROUND The addition of Tumor Treating Fields (TTFields) to the first-line therapy in glioblastoma (GBM) demonstrated significantly improved progression free survival, overall survival and longterm survival rates in the EF-14 phase 3 tr…
View article: P14.28 First report on the combination of axitinib and Tumor Treating Fields (TTFields) in three patients with recurrent glioblastoma
P14.28 First report on the combination of axitinib and Tumor Treating Fields (TTFields) in three patients with recurrent glioblastoma Open
BACKGROUND Adding Tumor Treating Fields (TTFields) to first-line therapy in glioblastoma (GBM) demonstrated significantly improved survival in the EF-14 trial. Furthermore, in a post-hoc analysis of the EF-14 trial, median overall survival…
View article: Clinical Utility of Different Approaches for Detection of Late Pseudoprogression in Glioblastoma With O-(2-[18F]Fluoroethyl)-l-Tyrosine PET
Clinical Utility of Different Approaches for Detection of Late Pseudoprogression in Glioblastoma With O-(2-[18F]Fluoroethyl)-l-Tyrosine PET Open
Purpose PET/CT using O-(2-[ 18 F]fluoroethyl)- l -tyrosine ( 18 F-FET) has proven valuable in differentiating tumor recurrence and progression from therapy-induced changes. This study aimed to investigate the diagnostic performance of seve…
View article: Circulating MACC1 Transcripts in Glioblastoma Patients Predict Prognosis and Treatment Response
Circulating MACC1 Transcripts in Glioblastoma Patients Predict Prognosis and Treatment Response Open
Glioblastoma multiforme is the most aggressive primary brain tumor of adults, but lacks reliable and liquid biomarkers. We evaluated circulating plasma transcripts of metastasis-associated in colon cancer-1 (MACC1), a prognostic biomarker …
View article: Tumor growth under rhGM‑CSF application in an orthotopic rodent glioma model
Tumor growth under rhGM‑CSF application in an orthotopic rodent glioma model Open
Regulation of the host immune response serves a pivotal role in the persistence and progression of malignant glioma. To date, cytotoxic cluster of differentiation (CD)-8+ T and natural killer cells are considered the main cellular componen…
View article: Expression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients
Expression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients Open
ATF5 mRNA expression could be identified as an additional, though not independent factor correlating with overall survival and PFS. Since its inhibition might lead to the selective death of glioma cells, it might serve as a potential ubiqu…
View article: Cerebellar liponeurocytoma - molecular signature of a rare entity and the importance of an accurate diagnosis
Cerebellar liponeurocytoma - molecular signature of a rare entity and the importance of an accurate diagnosis Open
Background: Cerebellar liponeurocytoma is an extremely rare tumour entity of the central nervous system. It is histologically characterised by prominent neuronal/neurocytic differentiation with focal lipidisation and corresponding histolog…
View article: HOUT-25. ADHERENCE TO TUMOR TREATING FIELDS IN PATIENTS WITH HIGH-GRADE GLIOMA – A SINGLE CENTER EXPERIENCE
HOUT-25. ADHERENCE TO TUMOR TREATING FIELDS IN PATIENTS WITH HIGH-GRADE GLIOMA – A SINGLE CENTER EXPERIENCE Open
BACKGROUND: The addition of alternating electric fields with low intensity (1–3 V/cm) and intermediate frequency (100–300 kHz), known as Tumor Treating Fields (TTFields), to adjuvant temozolomide demonstrated significant clinical benefits …
View article: OS4.3 The BReMen trial: Patients with benign meningioma - is rehabilitation really necessary?
OS4.3 The BReMen trial: Patients with benign meningioma - is rehabilitation really necessary? Open
Despite the good prognosis of benign meningioma, little is known about eventual impairment of patients’ psychological quality of life (pQoL), social and neuropsychological functioning after surgery. These patients might even fail to re-int…
View article: P01.046 Complete radiological response under treatment with Tumor Treating Fields following subtotal resection in a series of three Glioblastoma patients
P01.046 Complete radiological response under treatment with Tumor Treating Fields following subtotal resection in a series of three Glioblastoma patients Open
After subtotal resection (STR), residual contrast-enhancing glioblastoma multiforme (GBM) rarely undergo complete regression following radiochemotherapy and adjuvant chemotherapy. Moreover, in comparison to gross total resection (GTR) over…
View article: P01.050 Circulating MACC1 transcript plasma levels in glioblastoma patients segregate together with prognostic markers and treatment response
P01.050 Circulating MACC1 transcript plasma levels in glioblastoma patients segregate together with prognostic markers and treatment response Open
IDH1-mutation and MGMT-promoter methylation are established prognostic markers in glioblastoma multiforme (GBM); however, invasive procedures are needed to obtain the required tumor tissue. Metastasis-associated in colon cancer-1 (MACC1) h…
View article: P01.045 Adherence to Tumor Treating Fields in patients with high-grade glioma - a single center experience
P01.045 Adherence to Tumor Treating Fields in patients with high-grade glioma - a single center experience Open
The addition of alternating electric fields with low intensity (1–3 V/cm) and intermediate frequency (100–300 kHz), known as Tumor Treating Fields (TTFields), to adjuvant temozolomide after surgical resection and radiochemotherapy in patie…
View article: P01.047 Improving quality of life in glioma patients: platform for exchange of patients’ expertise in TTFields practice
P01.047 Improving quality of life in glioma patients: platform for exchange of patients’ expertise in TTFields practice Open
Glioblastoma (GBM) atients nd their elatives (PaR) face tremendous distress and psychological burden due to limited survival and neurological/neuropsychological deficits. Tumor Treating Fields (TTFields, alternating electric fields at 200 …
View article: High-grade glioma associated immunosuppression does not prevent immune responses induced by therapeutic vaccines in combination with Treg depletion
High-grade glioma associated immunosuppression does not prevent immune responses induced by therapeutic vaccines in combination with Treg depletion Open
High-grade gliomas (HGG) exert systemic immunosuppression, which is of particular importance as immunotherapeutic strategies such as therapeutic vaccines are increasingly used to treat HGGs. In a first cohort of 61 HGG patients we evaluate…
View article: QLIF-32. MEETING THE PATIENTS - MEETING THE NEEDS: PLATFORMS FOR PATIENTS USING OPTUNE® TO EXCHANGE EXPERTISE
QLIF-32. MEETING THE PATIENTS - MEETING THE NEEDS: PLATFORMS FOR PATIENTS USING OPTUNE® TO EXCHANGE EXPERTISE Open
INTRODUCTION: Glioblastoma multiforme (GBM) patients and their relatives (PaR) face tremendous distress and psychological burden due to limited survival and neurological/neuropsychological deficits. Tumor Treating Fields (Optune®, TTFields…
View article: P09.21 Complete radiological response after subtotal resection in two Gglioblastoma patients treated with Tumor Treating Fields
P09.21 Complete radiological response after subtotal resection in two Gglioblastoma patients treated with Tumor Treating Fields Open
Subtotal resection decreases significantly overall survival and progression free survival in glioblastoma multiforme (GBM), as compared to gross total resection. Residual contrast-enhancing tumors rarely vanish following radiation and chem…
View article: 3D rotational fluoroscopy for intraoperative clip control in patients with intracranial aneurysms – assessment of feasibility and image quality
3D rotational fluoroscopy for intraoperative clip control in patients with intracranial aneurysms – assessment of feasibility and image quality Open
This technique quickly supplies images at adequate quality to evaluate distal vessel patency after aneurysm clipping. Significant aneurysm remnants may be depicted as well. As it does not require visual control of all vessels that are supp…