Thomas Lorivel
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View article: Two pore domain THIK2 channel is involved in acute and chronic pain signal regulation
Two pore domain THIK2 channel is involved in acute and chronic pain signal regulation Open
Two-pore domain potassium channels (K 2P ) regulate neuronal excitability by acting as hyperpolarizing leak channels. Among them, THIK2 remain poorly characterized. Although no study has yet clearly linked them to excitability or pain, the…
View article: CHCHD10S59L/+ mouse model: Behavioral and neuropathological features of frontotemporal dementia
CHCHD10S59L/+ mouse model: Behavioral and neuropathological features of frontotemporal dementia Open
CHCHD10-related disease causes a spectrum of clinical presentations including mitochondrial myopathy, cardiomyopathy, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). We generated a knock-in mouse model bearing the p.…
View article: Dipeptidyl peptidase 4 contributes to Alzheimer’s disease–like defects in a mouse model and is increased in sporadic Alzheimer’s disease brains
Dipeptidyl peptidase 4 contributes to Alzheimer’s disease–like defects in a mouse model and is increased in sporadic Alzheimer’s disease brains Open
The amyloid cascade hypothesis, which proposes a prominent role for full-length amyloid β peptides in Alzheimer's disease, is currently being questioned. In addition to full-length amyloid β peptide, several N-terminally truncated fragment…
View article: Cytokine changes associated with the maternal immune activation (MIA) model of autism: A penalized regression approach
Cytokine changes associated with the maternal immune activation (MIA) model of autism: A penalized regression approach Open
Maternal immune activation (MIA) during pregnancy induces a cytokine storm that alters neurodevelopment and behavior in the progeny. In humans, MIA increases the odds of developing neuropsychiatric disorders such as autism spectrum disorde…
View article: Integration of behavioral and biological variables using penalized regression: an application to the maternal immune activation model of autism
Integration of behavioral and biological variables using penalized regression: an application to the maternal immune activation model of autism Open
Maternal immune activation (MIA) during pregnancy increases the odds of developing neuropsychiatric disorders such as autism spectrum disorder (ASD) later in life. In pregnant mice, MIA can be induced by injecting the viral mimic polyinosi…
View article: The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model
The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model Open
Neuronal network dysfunction and cognitive decline constitute the most prominent features of Alzheimer's disease (AD), although mechanisms causing such impairments are yet to be determined. Here we report that virus-mediated delivery of th…
View article: Positive effects of the traditional <scp>C</scp>hinese medicine <scp>MLC</scp>901 in cognitive tasks
Positive effects of the traditional <span>C</span>hinese medicine <span>MLC</span>901 in cognitive tasks Open
MLC901 (NurAiDII) is used as a treatment for stroke patients. It has been shown that MLC901 improves motor and cognitive recovery in ischemic and traumatic brain‐injured rodents. The present study seeks to delineate cognitive effects induc…