Thomas M. Best
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View article: Characterizing the Long Non-Coding RNA Profile of Endometrial Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Anti-Inflammatory Role in Osteoarthritis
Characterizing the Long Non-Coding RNA Profile of Endometrial Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Anti-Inflammatory Role in Osteoarthritis Open
Endometrial tissue-derived mesenchymal stem/stromal cells (eMSCs) have potential therapeutic properties partially exerted via their secreted extracellular vesicles (EVs). eMSC-EVs contain cargos with regenerative and immunomodulatory prope…
View article: Thawing the Ice: The Clinical Diagnosis and Effective Management of Adhesive Capsulitis
Thawing the Ice: The Clinical Diagnosis and Effective Management of Adhesive Capsulitis Open
Adhesive capsulitis (AC), commonly known as frozen shoulder (FS) or arthrofibrosis, is a condition characterized by progressive stiffness, loss of motion, and pain in the shoulder joint. It is a relatively common diagnosis that often has a…
View article: Ethnic differences in pain, function, and catastrophizing in South Florida adults with knee osteoarthritis
Ethnic differences in pain, function, and catastrophizing in South Florida adults with knee osteoarthritis Open
Objective Ethnicity is associated with varying reporting of pain, coping mechanisms, and disease severity in patients with knee osteoarthritis (KOA). However, few studies have evaluated its importance in ethnicity, particularly the Hispani…
View article: 455 | BENDAMUSTINE AS LYMPHODEPLETING CHEMOTHERAPY PRIOR TO AXICABTAGENE CILOLEUCEL FOR THE TREATMENT OF RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA
455 | BENDAMUSTINE AS LYMPHODEPLETING CHEMOTHERAPY PRIOR TO AXICABTAGENE CILOLEUCEL FOR THE TREATMENT OF RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA Open
View article: A Novel Treatment for Combined Adhesive Capsulitis and Glenohumeral Osteoarthritis – Case Study
A Novel Treatment for Combined Adhesive Capsulitis and Glenohumeral Osteoarthritis – Case Study Open
Adhesive capsulitis (AC) of the shoulder is a prevalent condition often characterized by a prolonged clinical course and significant patient morbidity, leading to a high socioeconomic burden. Despite numerous studies evaluating various tre…
View article: Reliability of artificial intelligence-driven markerless motion capture in gait analyses of healthy adults
Reliability of artificial intelligence-driven markerless motion capture in gait analyses of healthy adults Open
The KinaTrax markerless motion capture system, used extensively in the analysis of baseball pitching and hitting, is currently being adapted for use in clinical biomechanics. In clinical and laboratory environments, repeatability is inhere…
View article: The role of resistance training in mitigating cancer-induced cachexia: A systematic review
The role of resistance training in mitigating cancer-induced cachexia: A systematic review Open
The science of exercise interventions to improve outcomes in those with cancer-related cachexia is still emerging although progressive resistance training appears to be the most promising countermeasure. Authors encourage the development o…
View article: Knee joint mechanics during gait after anterior cruciate ligament reconstruction using a partial or full thickness quadriceps tendon autograft at 2 years after surgery
Knee joint mechanics during gait after anterior cruciate ligament reconstruction using a partial or full thickness quadriceps tendon autograft at 2 years after surgery Open
Background Despite quadriceps weakness in individuals after quadriceps tendon anterior cruciate ligament reconstruction (QT‐ACLR), and its association with knee joint mechanics, no studies have addressed gait mechanics in both partial‐thic…
View article: Comparative Analysis of Osteoarthritis Therapeutics: A Justification for Harnessing Retrospective Strategies via an Inverted Pyramid Model Approach
Comparative Analysis of Osteoarthritis Therapeutics: A Justification for Harnessing Retrospective Strategies via an Inverted Pyramid Model Approach Open
In this review, we seek to explore two distinct approaches to the clinical management of OA: a prospective approach, addressing primarily one’s genetic predisposition to OA and generating early intervention options, and the retrospective a…
View article: Multi-Modal Approach to Mitigating Hamstring Injuries in Division I College Football Athletes
Multi-Modal Approach to Mitigating Hamstring Injuries in Division I College Football Athletes Open
Hamstring injuries (HSIs) are prevalent in sports that involve changes in direction, kicking, and sprinting. These injuries are a major cause of time lost from competition, practice, and training, as well as increased healthcare costs. In …
View article: Interplay of Glucose Metabolism and Hippo Pathway in Chondrocytes: Pathophysiology and Therapeutic Targets
Interplay of Glucose Metabolism and Hippo Pathway in Chondrocytes: Pathophysiology and Therapeutic Targets Open
In this review, we explore the intricate relationship between glucose metabolism and mechanotransduction pathways, with a specific focus on the role of the Hippo signaling pathway in chondrocyte pathophysiology. Glucose metabolism is a vit…
View article: Cell-based therapy in the treatment of musculoskeletal diseases
Cell-based therapy in the treatment of musculoskeletal diseases Open
A limited number of tissues can spontaneously regenerate following injury, and even fewer can regenerate to a state comparable to mature, healthy adult tissue. Mesenchymal stem cells (MSCs) were first described in the 1960s-1970s by Friede…
View article: A hop testing alternative for functional performance following anterior cruciate ligament reconstruction
A hop testing alternative for functional performance following anterior cruciate ligament reconstruction Open
The purpose of this work was to provide a simple method to determine reactive strength during the 6-meter timed hop test (6mTH) and evaluate its association with isokinetic peak torque in patients following anterior cruciate ligament recon…
View article: Mechanical loading and orthobiologic therapies in the treatment of post-traumatic osteoarthritis (PTOA): a comprehensive review
Mechanical loading and orthobiologic therapies in the treatment of post-traumatic osteoarthritis (PTOA): a comprehensive review Open
The importance of mechanical loading and its relationship to orthobiologic therapies in the treatment of post-traumatic osteoarthritis (PTOA) is beginning to receive attention. This review explores the current efficacy of orthobiologic int…
View article: The Efficacy of Bone Marrow Stem Cell Therapy in Hip Osteoarthritis: A Scoping Review
The Efficacy of Bone Marrow Stem Cell Therapy in Hip Osteoarthritis: A Scoping Review Open
Background: Hip osteoarthritis (HOA) is a prevalent degenerative joint disease with various treatment approaches. Biological agents, such as bone-marrow derived stem cells (BM-MSC) therapy, have recently been proposed as a treatment option…
View article: Cellular and Structural Changes in Achilles and Patellar Tendinopathies: A Pilot In Vivo Study
Cellular and Structural Changes in Achilles and Patellar Tendinopathies: A Pilot In Vivo Study Open
Tendinopathies continue to be a challenge for both patients and the medical teams providing care as no universal clinical practice guidelines have been established. In general, tendinopathies are typically characterized by prolonged, local…
View article: Assessing the role of surface layer and molecular probe size in diffusion within meniscus tissue
Assessing the role of surface layer and molecular probe size in diffusion within meniscus tissue Open
Diffusion within extracellular matrix is essential to deliver nutrients and larger metabolites to the avascular region of the meniscus. It is well known that both structure and composition of the meniscus vary across its regions; therefore…
View article: A BIOPSYCHOSOCIAL APPROACH TOWARD PREDICTING PHYSICAL ACTIVITY AMONG OLDER ADULTS WITH KNEE OSTEOARTHRITIS
A BIOPSYCHOSOCIAL APPROACH TOWARD PREDICTING PHYSICAL ACTIVITY AMONG OLDER ADULTS WITH KNEE OSTEOARTHRITIS Open
Regular physical activity (PA) is imperative for preventing disability among older adults with knee osteoarthritis (KOA). However, PA is a complex behavior that relies on determinants from biological, psychological and social factors. Iden…
View article: Impact of Quadriceps Tendon Graft Thickness on Electromechanical Delay and Neuromuscular Performance After ACL Reconstruction
Impact of Quadriceps Tendon Graft Thickness on Electromechanical Delay and Neuromuscular Performance After ACL Reconstruction Open
Background: Both partial- and full-thickness quadriceps tendon (QT) graft harvests are used for anterior cruciate ligament reconstruction (ACLR). Purpose: To evaluate the impact of QT graft harvest depth (full or partial thickness) on elec…
View article: Hippo Signaling Modulates the Inflammatory Response of Chondrocytes to Mechanical Compressive Loading
Hippo Signaling Modulates the Inflammatory Response of Chondrocytes to Mechanical Compressive Loading Open
Knee osteoarthritis (KOA) is a degenerative disease resulting from mechanical overload, where direct physical impacts on chondrocytes play a crucial role in disease development by inducing inflammation and extracellular matrix degradation.…
View article: Real‐World Early Outcomes of Axicabtagene Ciloleucel for Relapsed or Refractory (R/R) Follicular Lymphoma (FL)
Real‐World Early Outcomes of Axicabtagene Ciloleucel for Relapsed or Refractory (R/R) Follicular Lymphoma (FL) Open
Background: Axicabtagene ciloleucel (axi-cel) is an autologous CAR T-cell therapy approved for adult patients (pts) with R/R FL after ≥2 lines of systemic therapy. In the primary analysis of the pivotal ZUMA-5 trial, 94% of pts who receive…
View article: Tensile energy dissipation and mechanical properties of the knee meniscus: relationship with fiber orientation, tissue layer, and water content
Tensile energy dissipation and mechanical properties of the knee meniscus: relationship with fiber orientation, tissue layer, and water content Open
Introduction: The knee meniscus distributes and dampens mechanical loads. It is composed of water (∼70%) and a porous fibrous matrix (∼30%) with a central core that is reinforced by circumferential collagen fibers enclosed by mesh-like sup…
View article: CD10-Bound Human Mesenchymal Stem/Stromal Cell-Derived Exosomes Possess Immunomodulatory Cargo and Maintain Cartilage Homeostasis under Inflammatory Conditions
CD10-Bound Human Mesenchymal Stem/Stromal Cell-Derived Exosomes Possess Immunomodulatory Cargo and Maintain Cartilage Homeostasis under Inflammatory Conditions Open
The onset and progression of human inflammatory joint diseases are strongly controlled by the activation of resident synovium/infrapatellar fat pad (IFP) pro-inflammatory and pain-transmitting signaling. We recently reported that intra-art…
View article: The roles and therapeutic potentialof mesenchymal stem/stromal cells and their extracellular vesicles in tendinopathies
The roles and therapeutic potentialof mesenchymal stem/stromal cells and their extracellular vesicles in tendinopathies Open
Tendinopathies encompass a highly prevalent, multi-faceted spectrum of disorders, characterized by activity-related pain, compromised function, and propensity for an extended absence from sport and the workplace. The pathophysiology of ten…
View article: CD146+ Endometrial-Derived Mesenchymal Stem/Stromal Cell Subpopulation Possesses Exosomal Secretomes with Strong Immunomodulatory miRNA Attributes
CD146+ Endometrial-Derived Mesenchymal Stem/Stromal Cell Subpopulation Possesses Exosomal Secretomes with Strong Immunomodulatory miRNA Attributes Open
The perivascular localization of endometrial mesenchymal stem/stromal cells (eMSC) allows them to sense local and distant tissue damage, promoting tissue repair and healing. Our hypothesis is that eMSC therapeutic effects are largely exert…
View article: Gene Expression and Chondrogenic Potential of Cartilage Cells: Osteoarthritis Grade Differences
Gene Expression and Chondrogenic Potential of Cartilage Cells: Osteoarthritis Grade Differences Open
Recent data suggest that cells isolated from osteoarthritic (OA) cartilage express mesenchymal progenitor cell (MPC) markers that have the capacity to form hyaline-like cartilage tissue. Whether or not these cells are influenced by the sev…
View article: Cardiac Troponin Testing as a Component of Return to Play Cardiac Screening in Young Competitive Athletes Following SARS‐CoV‐2 Infection
Cardiac Troponin Testing as a Component of Return to Play Cardiac Screening in Young Competitive Athletes Following SARS‐CoV‐2 Infection Open
Background Initial protocols for return to play cardiac testing in young competitive athletes following SARS‐CoV‐2 infection recommended cardiac troponin (cTn) to screen for cardiac involvement. This study aimed to define the diagnostic yi…
View article: Nonsteroidal Anti-inflammatory and Corticosteroid Injections for Shoulder Impingement Syndrome: A Systematic Review and Meta-analysis
Nonsteroidal Anti-inflammatory and Corticosteroid Injections for Shoulder Impingement Syndrome: A Systematic Review and Meta-analysis Open
Context: To determine optimal treatment strategies for shoulder impingement syndrome (SIS). Objective: To compare subacromial nonsteroidal anti-inflammatory injections (SNIs) and subacromial corticosteroid injections (SCIs) on pain relief …
View article: Long-term cardiac surveillance and outcomes of COVID-19 patients
Long-term cardiac surveillance and outcomes of COVID-19 patients Open
View article: Human infrapatellar fat pad mesenchymal stem cells show immunomodulatory exosomal signatures
Human infrapatellar fat pad mesenchymal stem cells show immunomodulatory exosomal signatures Open
Within the human knee infrapatellar fat pad (IFP) and synovium, resident synoviocytes and macrophages contribute to the onset and progression of inflammatory joint diseases. Our hypothesis is that IFP-derived mesenchymal stem cells (IFP-MS…