Thomas M. Kessler
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View article: Assessing sexual function in neurorehabilitation: insights and challenges from a spinal cord injury cohort
Assessing sexual function in neurorehabilitation: insights and challenges from a spinal cord injury cohort Open
Background Although sexual dysfunction after spinal cord injury (SCI) is common and impacts quality of life, healthcare professionals may avoid this topic due to discomfort and knowledge gaps. Missing sexual health data can bias research f…
View article: Bacteriophage therapy plus fecal microbiota transplantation to treat recurrent urinary tract infection (rUTI): a case series
Bacteriophage therapy plus fecal microbiota transplantation to treat recurrent urinary tract infection (rUTI): a case series Open
Recurrent urinary tract infections (rUTIs) are a chronic, debilitating condition characterized by repeated infections and treatment failure with antibiotics. We present an attempt to decolonize the urinary and intestinal reservoirs between…
View article: Male sex is a risk factor for detrusor pressure jeopardising the upper urinary tract in patients with spinal cord injury
Male sex is a risk factor for detrusor pressure jeopardising the upper urinary tract in patients with spinal cord injury Open
Objective To evaluate sex differences in maximum storage detrusor pressure (Pdet max storage), focusing on Pdet max storage ≥40 cmH 2 O, an established risk factor for upper urinary tract damage, within the first year after spinal cord inj…
View article: Lower urinary tract sensory assessments in patients with neurogenic lower urinary tract dysfunction undergoing sacral neuromodulation
Lower urinary tract sensory assessments in patients with neurogenic lower urinary tract dysfunction undergoing sacral neuromodulation Open
LUTESA is feasible in patients with NLUTD and may help to better characterize patients for tailored treatment options.
View article: Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia
Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia Open
Objective Impaired ability to induce stepping after incomplete spinal cord injury (SCI) can limit the efficacy of locomotor training, often leaving patients wheelchair‐bound. The cuneiform nucleus (CNF), a key mesencephalic locomotor contr…
View article: Conus medullaris and cauda equina syndrome as complications of non-imaging guided epidural steroid injection: two case reports with comprehensive interdisciplinary work-up
Conus medullaris and cauda equina syndrome as complications of non-imaging guided epidural steroid injection: two case reports with comprehensive interdisciplinary work-up Open
Introduction Epidural steroid injection (ESI) is commonly performed in the outpatient setting for relieving lumbosacral radicular pain, i.e., sciatica. Neurological and neuro-urological adverse events are rare but devastating when occurrin…
View article: Timing of urological management during post‐acute spinal cord injury rehabilitation
Timing of urological management during post‐acute spinal cord injury rehabilitation Open
Objectives To provide a population‐based description of the timing and indicators of bladder storage medication and method of bladder emptying during post‐acute specialised spinal cord injury (SCI) rehabilitation. Patients and Methods Data…
View article: European Academy of Neurology (<scp>EAN</scp>)/European Federation of Autonomic Societies (<scp>EFAS</scp>)/International Neuro‐Urology Society (<scp>INUS</scp>) Guidelines for Practising Neurologists on the Assessment and Treatment of Neurogenic Urinary and Sexual Symptoms (<scp>NEUROGED</scp> Guidelines)
European Academy of Neurology (<span>EAN</span>)/European Federation of Autonomic Societies (<span>EFAS</span>)/International Neuro‐Urology Society (<span>INUS</span>) Guidelines for Practising Neurologists on the Assessment and Treatment of Neurogenic Urinary and Sexual Symptoms (<span>NEUROGED</span> Guidelines) Open
Background Urinary and sexual symptoms are common following neurological disease, and we aimed to develop multidisciplinary inter‐society evidence‐based management guidelines. Methods The ADAPTE framework was used, and a systematic search …
View article: Similar artefact susceptibility for water‐ and air‐filled urodynamic systems: a non‐inferiority randomised controlled trial
Similar artefact susceptibility for water‐ and air‐filled urodynamic systems: a non‐inferiority randomised controlled trial Open
Objectives To determine whether air‐filled systems (AFS) provide comparable urodynamic investigation (UDI) trace quality to water‐filled systems (WFS), the recommended standard by the International Continence Society. Patients and Methods …
View article: Remote neurodegeneration in the lumbosacral cord one month after spinal cord injury: a cross‐sectional <scp>MRI</scp> study
Remote neurodegeneration in the lumbosacral cord one month after spinal cord injury: a cross‐sectional <span>MRI</span> study Open
Objective To characterize structural integrity of the lumbosacral enlargement and conus medullaris within one month after spinal cord injury (SCI). Methods Lumbosacral cord MRI data were acquired in patients with sudden onset (<7 days) SCI…
View article: Innovations in Phage Therapy for Urinary Tract Infection
Innovations in Phage Therapy for Urinary Tract Infection Open
Urinary tract infections (UTIs) are among the most common infections. Increasing rates of multidrug-resistant bacteria are complicating treatment, necessitating alternative strategies. Bacteriophages (phages) are viruses that only target a…
View article: Improved inter-subject alignment of the lumbosacral cord for group-level in vivo gray and white matter assessments: A scan-rescan MRI study at 3T
Improved inter-subject alignment of the lumbosacral cord for group-level in vivo gray and white matter assessments: A scan-rescan MRI study at 3T Open
Introduction Magnetic resonance imaging (MRI) enables the investigation of pathological changes in gray and white matter at the lumbosacral enlargement (LSE) and conus medullaris (CM). However, conducting group-level analyses of MRI metric…
View article: The Role of Misrecognition in Driving Support for Right-Wing Populism
The Role of Misrecognition in Driving Support for Right-Wing Populism Open
Recent research suggests that citizens’ sense of being socially marginalized, or “left behind” in society, plays an important role in triggering support for right-wing populist attitudes. Although perceived misrecognition by others is thou…
View article: Improved Inter-Subject Alignment of the Lumbosacral Cord for Group-Level In Vivo Gray and White Matter Assessments: A Scan-Rescan MRI Study at 3T
Improved Inter-Subject Alignment of the Lumbosacral Cord for Group-Level In Vivo Gray and White Matter Assessments: A Scan-Rescan MRI Study at 3T Open
Introduction Magnetic resonance imaging (MRI) enables the investigation of pathological changes in gray and white matter at the lumbosacral enlargement (LSE) and conus medullaris (CM). However, conducting group-level analyses of MRI metric…
View article: Neuro-Urology and Biobanking: An Integrated Approach for Advancing Research and Improving Patient Care
Neuro-Urology and Biobanking: An Integrated Approach for Advancing Research and Improving Patient Care Open
Understanding the molecular mechanisms underlying neuro-urological disorders is crucial for the development of targeted therapeutic interventions. Through the establishment of comprehensive biobanks, researchers can collect and store vario…
View article: Enhancing bacteriophage therapeutics through in situ production and release of heterologous antimicrobial effectors
Enhancing bacteriophage therapeutics through in situ production and release of heterologous antimicrobial effectors Open
Bacteriophages operate via pathogen-specific mechanisms of action distinct from conventional, broad-spectrum antibiotics and are emerging as promising alternative antimicrobials. However, phage-mediated killing is often limited by bacteria…
View article: Development of a Sham Protocol to Investigate Transcutaneous Tibial Nerve Stimulation in Randomised, Sham-Controlled, Double-Blind Clinical Trials
Development of a Sham Protocol to Investigate Transcutaneous Tibial Nerve Stimulation in Randomised, Sham-Controlled, Double-Blind Clinical Trials Open
Transcutaneous tibial nerve stimulation (TTNS) is a promising treatment for neurogenic lower urinary tract symptoms. However, the evidence is limited due to a general lack of randomised controlled trials (RCTs) and, also, inconsistency in …
View article: Urodynamics Are Essential to Predict the Risk for Upper Urinary Tract Damage after Acute Spinal Cord Injury
Urodynamics Are Essential to Predict the Risk for Upper Urinary Tract Damage after Acute Spinal Cord Injury Open
We used clinical parameters to develop a prediction model for the occurrence of urodynamic risk factors for upper urinary tract (UUT) damage during the first year after acute spinal cord injury (SCI). A total of 97 patients underwent urody…
View article: Prediction of Lower Urinary Tract, Sexual, and Bowel Function, and Autonomic Dysreflexia after Spinal Cord Injury
Prediction of Lower Urinary Tract, Sexual, and Bowel Function, and Autonomic Dysreflexia after Spinal Cord Injury Open
Spinal cord injury (SCI) produces damage to the somatic and autonomic pathways that regulate lower urinary tract, sexual, and bowel function, and increases the risk of autonomic dysreflexia. The recovery of these functions has a high impac…
View article: Abnormal Resting-State Network Presence in Females with Overactive Bladder
Abnormal Resting-State Network Presence in Females with Overactive Bladder Open
Overactive bladder (OAB) is a global problem reducing the quality of life of patients and increasing the costs of any healthcare system. The etiology of OAB is understudied but likely involves supraspinal network alterations. Here, we char…
View article: <scp>bTUNED</scp> : transcutaneous tibial nerve stimulation for neurogenic lower urinary tract dysfunction
<span>bTUNED</span> : transcutaneous tibial nerve stimulation for neurogenic lower urinary tract dysfunction Open
Objective To present the protocol for a randomized controlled trial (RCT) evaluating the efficacy and safety of transcutaneous tibial nerve stimulation (TTNS) for refractory neurogenic lower urinary tract dysfunction (NLUTD). Study Design …
View article: The implications of neurogenic bowel dysfuncton for urinary tract reconstruction in neurogenic urinary tract dysfunction: An International Continence Society working group report
The implications of neurogenic bowel dysfuncton for urinary tract reconstruction in neurogenic urinary tract dysfunction: An International Continence Society working group report Open
Introduction:: The consequences of neurogenic bowel dysfunction in patients with neurogenic lower urinary tract disease requiring urinary tract reconstruction with bowel harvest remains unclear. A working group was formed by the Internatio…
View article: Context-level contact as a stronger predictor of inter-ethnic reconciliation than individual-level contact: Evidence from post-war countries
Context-level contact as a stronger predictor of inter-ethnic reconciliation than individual-level contact: Evidence from post-war countries Open
Is post-war reconciliation determined by individuals’ personal contact experiences with former adversaries, or by the amount of intergroup contact within the region in which they live? Using multilevel analyses among representative samples…