Thomas Marjot
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View article: Sleep improvement for metabolic health: A feasibility trial of a digital sleep treatment in people with insomnia and non-diabetic hyperglycaemia
Sleep improvement for metabolic health: A feasibility trial of a digital sleep treatment in people with insomnia and non-diabetic hyperglycaemia Open
Insomnia may play a causal role in type 2 diabetes (T2D). Addressing insomnia through cognitive behavioural therapy (CBTi) in people with non-diabetic hyperglycaemia could potentially reduce the risk of progression to T2D. To inform a futu…
View article: The barriers to uptake of artificial intelligence in hepatology and how to overcome them
The barriers to uptake of artificial intelligence in hepatology and how to overcome them Open
Artificial intelligence (AI) methods in hepatology have proliferated since the mid-2010s, with numerous publications and some regulatory approvals. Yet, adoption of AI methods in real-world clinical practice and clinical research remains l…
View article: Dose-dependent and tissue-specific adverse effects of exogenous glucocorticoids: insights for optimizing clinical practice
Dose-dependent and tissue-specific adverse effects of exogenous glucocorticoids: insights for optimizing clinical practice Open
Purpose There is limited data on dose-specific metabolic effects of exogenous glucocorticoids (GC) doses. This study aimed to investigate the differential tissue-specific and dose-dependent effects of low-to-intermediate prednisolone doses…
View article: Skeletal muscle and MASLD: Mechanistic and clinical insights
Skeletal muscle and MASLD: Mechanistic and clinical insights Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) is intrinsically linked with widespread metabolic perturbations, including within skeletal muscle. Indeed, MASLD is associated with a range of skeletal muscle abnormalities, …
View article: Evaluating Disparities in <scp>COVID</scp>‐19 Clinical Outcomes Among Patients With Cirrhosis in North America and Europe—An International Registry Study
Evaluating Disparities in <span>COVID</span>‐19 Clinical Outcomes Among Patients With Cirrhosis in North America and Europe—An International Registry Study Open
Background Patients with decompensated cirrhosis have a higher risk of hospitalization, ICU admission, and death from COVID‐19. The impact of demographics on these outcomes remains uncertain. Methods The SECURE‐Liver and COVID‐Hep database…
View article: Dissociation between liver fat content and fasting metabolic markers of selective hepatic insulin resistance in humans
Dissociation between liver fat content and fasting metabolic markers of selective hepatic insulin resistance in humans Open
Objective Fasting hyperglycemia and hypertriglyceridemia are characteristic of insulin resistance (IR) and rodent work has suggested this may be due to selective hepatic IR, defined by increased hepatic gluconeogenesis and de novo lipogene…
View article: Impact of SARS-CoV-2 vaccination in patients with vascular liver diseases: Observations from a VALDIG multicenter study
Impact of SARS-CoV-2 vaccination in patients with vascular liver diseases: Observations from a VALDIG multicenter study Open
View article: Glycated haemoglobin is a major predictor of disease severity in patients with NAFLD
Glycated haemoglobin is a major predictor of disease severity in patients with NAFLD Open
View article: Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial
Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial Open
BACKGROUND: The humoral and T-cell responses to booster COVID-19 vaccine types in multidisease immunocompromised individuals who do not generate adequate antibody responses to two COVID-19 vaccine doses, is not fully understood. The OCTAVE…
View article: Recruitment, Retention, and Training of Citizen Scientists in Translational Medicine Research: A Citizen Science Initiative on Non-Alcoholic Fatty Liver Disease
Recruitment, Retention, and Training of Citizen Scientists in Translational Medicine Research: A Citizen Science Initiative on Non-Alcoholic Fatty Liver Disease Open
View article: Evaluating Disparities in COVID‐19 Clinical Outcomes Among Patients With Cirrhosis in North America and Europe—An International Registry Study
Evaluating Disparities in COVID‐19 Clinical Outcomes Among Patients With Cirrhosis in North America and Europe—An International Registry Study Open
Background Patients with decompensated cirrhosis have a higher risk of hospitalization, ICU admission, and death from COVID‐19. The impact of demographics on these outcomes remains uncertain. Methods The SECURE‐Liver and COVID‐Hep database…
View article: Shift work and evening chronotype are associated with hepatic fat fraction and non-alcoholic fatty liver disease in 282,303 UK biobank participants
Shift work and evening chronotype are associated with hepatic fat fraction and non-alcoholic fatty liver disease in 282,303 UK biobank participants Open
Background and aims Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common liver disease worldwide. Modern lifestyles have been linked to this rise in prevalence with changes in rhythmic human behaviour emerging as a …
View article: Immune responses and clinical outcomes after COVID-19 vaccination in patients with liver disease and liver transplant recipients
Immune responses and clinical outcomes after COVID-19 vaccination in patients with liver disease and liver transplant recipients Open
Standardised assessments of the immune response to different COVID-19 vaccines in patients with liver disease are lacking. We performed antibody and T-cell assays at multiple timepoints following up to three vaccine doses in a large cohort…
View article: Circadian regulation of liver metabolism: experimental approaches in human, rodent, and cellular models
Circadian regulation of liver metabolism: experimental approaches in human, rodent, and cellular models Open
Over the past decade, there has been an increased interest in understanding the intricate relationship between circadian rhythm and liver metabolism. In this review, we have systematically searched the literature to analyze the various exp…
View article: National study of NAFLD management identifies variation in delivery of care in the UK between 2019 to 2022
National study of NAFLD management identifies variation in delivery of care in the UK between 2019 to 2022 Open
This study identified significant variation in the management of NAFLD in the UK. Only 27.9% of patients with suspected NAFLD had non-invasive fibrosis assessment performed to identify those at greater risk of advanced liver disease before…
View article: SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease
SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVI…
View article: Defining characteristics and outcomes for patients with non-alcoholic fatty liver disease admitted to hospital with decompensated cirrhosis
Defining characteristics and outcomes for patients with non-alcoholic fatty liver disease admitted to hospital with decompensated cirrhosis Open
View article: Timing of energy intake and the therapeutic potential of intermittent fasting and time-restricted eating in NAFLD
Timing of energy intake and the therapeutic potential of intermittent fasting and time-restricted eating in NAFLD Open
Non-alcoholic fatty liver disease (NAFLD) represents a major public health concern and is associated with a substantial global burden of liver-related and cardiovascular-related morbidity and mortality. High total energy intake coupled wit…
View article: Adopting a citizen science approach in translational experimental medicine research in non-alcoholic fatty liver disease: A study protocol
Adopting a citizen science approach in translational experimental medicine research in non-alcoholic fatty liver disease: A study protocol Open
Background Citizen science approaches are widely and successfully used in biological, environmental, and ecological sciences; however, they are rarely applied in other domains, such as translational health research, notably in the field of…
View article: 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial
11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial Open
View article: Adopting a Citizen Science Approach in Translational Experimental Medicine Research in Non-Alcoholic Fatty Liver Disease: A Study Protocol
Adopting a Citizen Science Approach in Translational Experimental Medicine Research in Non-Alcoholic Fatty Liver Disease: A Study Protocol Open
Citizen science approaches are widely and successfully used in biological, environmental, and ecological sciences; however, they are rarely applied in other domains, such as translational health research, notably in the field of liver dise…
View article: FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2 Open
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2)1, could represent a new chemoprophylactic approach for COVID-19 that complements vaccination2,3. However, the mechanisms tha…
View article: FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2 Open
View article: SARS-CoV-2 Infection and Liver Disease: A Review of Pathogenesis and Outcomes
SARS-CoV-2 Infection and Liver Disease: A Review of Pathogenesis and Outcomes Open
The impact of the coronavirus disease 2019 (COVID-19) pandemic has been immense, and it continues to have lasting repercussions. While the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus primarily infects the respiratory…
View article: Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: An updated EASL position paper
Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: An updated EASL position paper Open
View article: T cell and humoral immune response to multiple SARS-CoV-2 variants including omicron (B1.1.529) after two doses of COVID-19 vaccine in patients with cirrhosis and liver diseases requiring immunosuppression: data from the EASL COVID-Hep network
T cell and humoral immune response to multiple SARS-CoV-2 variants including omicron (B1.1.529) after two doses of COVID-19 vaccine in patients with cirrhosis and liver diseases requiring immunosuppression: data from the EASL COVID-Hep network Open
View article: Humoral and cellular immune responses to wild-type and omicron (B.1.1.529) SARS-CoV-2 variants following a fourth COVID-19 vaccination in liver transplant recipients and patients with autoimmune hepatitis
Humoral and cellular immune responses to wild-type and omicron (B.1.1.529) SARS-CoV-2 variants following a fourth COVID-19 vaccination in liver transplant recipients and patients with autoimmune hepatitis Open
View article: Humoral and cellular immune responses to SARS-CoV-2 vaccination across multiple vaccine platforms and liver disease types: an EASL registry multicentre prospective cohort study
Humoral and cellular immune responses to SARS-CoV-2 vaccination across multiple vaccine platforms and liver disease types: an EASL registry multicentre prospective cohort study Open
View article: Shift work and evening chronotype are related to prevalent non-alcoholic fatty liver disease in 282,303 UK biobank participants
Shift work and evening chronotype are related to prevalent non-alcoholic fatty liver disease in 282,303 UK biobank participants Open
Background & Aims Non-alcoholic fatty liver disease (NAFLD) is globally prevalent and confers a high risk of morbidity via progression to non-alcoholic steatohepatitis (NASH). Circadian disruption in mouse models contributes to the develop…
View article: SARS‐CoV‐2 Infections Among Patients With Liver Disease and Liver Transplantation Who Received COVID‐19 Vaccination
SARS‐CoV‐2 Infections Among Patients With Liver Disease and Liver Transplantation Who Received COVID‐19 Vaccination Open
Many safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations dramatically reduce risks of coronavirus disease 2019 (COVID-19) complications and deaths. We aimed to describe cases of SARS-CoV-2 infection…