Thomas McKee
YOU?
Author Swipe
View article: A robust classifier for the intrinsic consensus molecular subtypes in colorectal cancer.
A robust classifier for the intrinsic consensus molecular subtypes in colorectal cancer. Open
Background: An analysis of colorectal cancer epithelial cells showed two intrinsic subtypes called iCMS2 and iCMS3, in addition to the bulk consensus subtypes (CMS1-4). The intrinsic subtypes can be prognostically important in some patient…
View article: Geneva Homologous Recombination Deficiency Test Is Predictive of Survival Benefit From Olaparib and Bevacizumab Maintenance in Ovarian Cancer
Geneva Homologous Recombination Deficiency Test Is Predictive of Survival Benefit From Olaparib and Bevacizumab Maintenance in Ovarian Cancer Open
PURPOSE The ability of the Geneva homologous recombination deficiency (HRD) test to predict progression-free survival (PFS) in patients with high-grade ovarian cancer treated with poly (ADP-ribose) polymerase inhibitors has been demonstrat…
View article: BRCA2 germline mutation carrier with five malignancies: a case report
BRCA2 germline mutation carrier with five malignancies: a case report Open
Background BRCA2 germline mutations are known to predispose carriers to various cancer types, including breast, ovarian, pancreatic and prostate cancer. An association with melanoma has also been reported. However, the full tumour spectrum…
View article: BRCA2 germline mutation carrier with five malignancies: a case study
BRCA2 germline mutation carrier with five malignancies: a case study Open
Background BRCA2 germline mutations are known to predispose carriers to various cancer types, including breast, ovarian, pancreatic and prostate cancer. An association with melanoma has also been reported. However, the full tumour spectrum…
View article: Effectiveness of fractionated rituximab in preventing tumor lysis syndrome in aggressive <scp>B‐</scp>cell lymphoma: Insights from real‐life clinical practice
Effectiveness of fractionated rituximab in preventing tumor lysis syndrome in aggressive <span>B‐</span>cell lymphoma: Insights from real‐life clinical practice Open
Background Tumor lysis syndrome (TLS) is a potentially life‐threatening condition resulting from the rapid destruction of malignant cells, leading to electrolyte imbalances and severe complications, such as acute kidney injury, arrhythmias…
View article: GSDMD is associated with survival in human breast cancer but does not impact anti-tumor immunity in a mouse breast cancer model
GSDMD is associated with survival in human breast cancer but does not impact anti-tumor immunity in a mouse breast cancer model Open
Inflammation plays a pivotal role in cancer development, with chronic inflammation promoting tumor progression and treatment resistance, whereas acute inflammatory responses contribute to protective anti-tumor immunity. Gasdermin D (GSDMD)…
View article: High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency–Associated Genomic Instability in Ovarian Cancer
High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency–Associated Genomic Instability in Ovarian Cancer Open
PURPOSE Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown promising clinical results in the treatment of ovarian cancer. Analysis of biomarker subgroups consistently revealed higher benefits for patients with homologous recombinati…
View article: Neoantigen-specific T-cell response after donor lymphocyte infusion associates with favorable outcome in a patient with i(12p) germ cell tumor, acute leukemia and sarcoma of the same clonal origin
Neoantigen-specific T-cell response after donor lymphocyte infusion associates with favorable outcome in a patient with i(12p) germ cell tumor, acute leukemia and sarcoma of the same clonal origin Open
Not available.
View article: PO009/#424 Innovative academic homologous recombination deficiency tests available in advanced ovarian cancer: the European ENGOT initiative
PO009/#424 Innovative academic homologous recombination deficiency tests available in advanced ovarian cancer: the European ENGOT initiative Open
Introduction Recently the PAOLA-1/ENGOT-ov25 phase-3 study (Ray-Coquard ESMO-2022) showed that the addition of olaparib maintenance to 1st-line platinum-based therapy and bevacizumab improved survival of advanced ovarian cancer (AOC) patie…
View article: Effectiveness of Fractionated Rituximab in Preventing Tumor Lysis Syndrome in Aggressive B-Cell Lymphoma: Insights from Real-Life Clinical Practice
Effectiveness of Fractionated Rituximab in Preventing Tumor Lysis Syndrome in Aggressive B-Cell Lymphoma: Insights from Real-Life Clinical Practice Open
Tumor lysis syndrome (TLS) is a life-threatening condition caused by the rapid destruction of malignant cells, leading to imbalances in electrolytes and posing risks such as acute kidney injury, arrhythmia, and seizures. This retrospective…
View article: <i>CXCL9:SPP1</i> macrophage polarity identifies a network of cellular programs that control human cancers
<i>CXCL9:SPP1</i> macrophage polarity identifies a network of cellular programs that control human cancers Open
Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs and disease outcome, we f…
View article: Normalized LST Is an Efficient Biomarker for Homologous Recombination Deficiency and Olaparib Response in Ovarian Carcinoma
Normalized LST Is an Efficient Biomarker for Homologous Recombination Deficiency and Olaparib Response in Ovarian Carcinoma Open
PURPOSE The efficiency of the Myriad Homologous Recombination Deficiency (HRD) test to guide the use of poly (ADP-ribose) polymerase (PARP) inhibitors has been demonstrated in several phase III trials. However, a need exists for alternativ…
View article: Supplementary Figure1 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer
Supplementary Figure1 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer Open
Correlation was shown between SMAD4 mRNA expression (gene expression data) and protein expression (IHC).
View article: Data from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer
Data from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer Open
Purpose: SMAD4 loss is associated with the development of metastases and poor prognosis. We evaluated expression of SMAD4 protein and its association with tumor characteristics, including biomarkers and outcome in terms of relapse-free sur…
View article: Supplementary figure legend from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer
Supplementary figure legend from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer Open
Legends for supplementary figures 1 and 2
View article: Supplementary Figure S4 from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL
Supplementary Figure S4 from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL Open
Healthy B-cells are CXCL-8 negative.
View article: Supplementary Figure S2 from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL
Supplementary Figure S2 from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL Open
APRIL-producing neutrophils infiltrate the tumor nest.
View article: Supplementary table 1 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer
Supplementary table 1 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer Open
Correlation between SMAD4 expression and FOLFIRI and 5-FU/FA treatment
View article: Supplementary Figure S1 from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL
Supplementary Figure S1 from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL Open
CXCL-8 is the unique neutrophil chemokine detectable in DLBCL biopsies.
View article: Supplementary table 1 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer
Supplementary table 1 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer Open
Correlation between SMAD4 expression and FOLFIRI and 5-FU/FA treatment
View article: Supplementary Figure S4 from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL
Supplementary Figure S4 from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL Open
Healthy B-cells are CXCL-8 negative.
View article: Supplementary Figure2 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer
Supplementary Figure2 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer Open
Kaplan-Meier curves for RFS (A, C) and OS (B, D) of the MSS (A, B) and of the MSI (C, D) patients, respectively by SMAD4 expression status
View article: Supplementary Figure1 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer
Supplementary Figure1 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer Open
Correlation was shown between SMAD4 mRNA expression (gene expression data) and protein expression (IHC).
View article: Data from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer
Data from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer Open
Purpose: SMAD4 loss is associated with the development of metastases and poor prognosis. We evaluated expression of SMAD4 protein and its association with tumor characteristics, including biomarkers and outcome in terms of relapse-free sur…
View article: Supplementary Figure2 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer
Supplementary Figure2 from Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer Open
Kaplan-Meier curves for RFS (A, C) and OS (B, D) of the MSS (A, B) and of the MSI (C, D) patients, respectively by SMAD4 expression status
View article: Data from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL
Data from CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL Open
Tumor-infiltrating neutrophils have been implicated in malignant development and progression, but mechanisms are ill defined. Neutrophils produce a proliferation-inducing ligand APRIL/TNFSF13, a factor that promotes development of tumors f…