Thomas Mindos
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View article: Preclinical assessment of MEK1/2 inhibitors for neurofibromatosis type 2–associated schwannomas reveals differences in efficacy and drug resistance development
Preclinical assessment of MEK1/2 inhibitors for neurofibromatosis type 2–associated schwannomas reveals differences in efficacy and drug resistance development Open
MEK inhibitors exhibited differences in antitumor efficacy resistance in schwannoma models with possible emergence of trametinib resistance. The results support further investigation of MEK inhibitors in combination with other targeted dru…
View article: Inflammaging impairs peripheral nerve maintenance and regeneration
Inflammaging impairs peripheral nerve maintenance and regeneration Open
The regenerative capacity of peripheral nerves declines during aging, contributing to the development of neuropathies, limiting organism function. Changes in Schwann cells prompt failures in instructing maintenance and regeneration of agin…
View article: Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity
Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity Open
Loss of the Merlin tumor suppressor and activation of the Hippo signaling pathway play major roles in the control of cell proliferation and tumorigenesis. We have identified completely novel roles for Merlin and the Hippo pathway effector …
View article: Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve
Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve Open
Correct myelination is crucial for the function of the peripheral nervous system. Both positive and negative regulators within the axon and Schwann cell function to ensure the correct onset and progression of myelination during both develo…
View article: The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair
The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair Open
Myelination in the peripheral nervous system ( PNS ) is controlled by both positive and negative regulators within Schwann cells to ensure timely onset and correct myelin thickness for saltatory conduction by neurons. Transcription factors…