Thomas Minor
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View article: Tissue inhibitor of metalloproteinase-2 predicts early allograft dysfunction after liver transplantation
Tissue inhibitor of metalloproteinase-2 predicts early allograft dysfunction after liver transplantation Open
View article: Opportunities and challenges with the implementation of normothermic machine perfusion in kidney transplantation
Opportunities and challenges with the implementation of normothermic machine perfusion in kidney transplantation Open
View article: End-ischemic pharmacological cocktail treatment to mitigate rewarming/reperfusion injury
End-ischemic pharmacological cocktail treatment to mitigate rewarming/reperfusion injury Open
Increasing shortage of donor organs leads to the acceptance of less than optimal grafts for transplantation, up to and including organs donated after circulatory standstill of the donor. Therefore, protective strategies and pharmacological…
View article: Noninvasive measurement of 13Carbon turnover for evaluation of porcine renal grafts during ex vivo machine perfusion
Noninvasive measurement of 13Carbon turnover for evaluation of porcine renal grafts during ex vivo machine perfusion Open
View article: Role of perfusion medium in rewarming machine perfusion from hypo‐ to normothermia
Role of perfusion medium in rewarming machine perfusion from hypo‐ to normothermia Open
Background Gradual warming up of cold stored organ grafts using a controlled machine perfusion protocol facilitates restitution of cellular homeostasis and mitigates rewarming injury by adapted increase of temperature and metabolism. The a…
View article: Comparison Between Terminal or Preterminal Conditioning of Donor Livers by Ex Situ Machine Perfusion
Comparison Between Terminal or Preterminal Conditioning of Donor Livers by Ex Situ Machine Perfusion Open
Background. The successful implementation of end-ischemic normothermic machine perfusion (NMP) into clinical practice comes along with unusual demands for trained personnel and technical facilities in the implantation clinic. This creates …
View article: The impact of oxygen supply and erythrocytes during normothermic kidney perfusion
The impact of oxygen supply and erythrocytes during normothermic kidney perfusion Open
The influence of erythrocytes and oxygen concentration on kidneys during long-term normothermic kidney perfusion is under debate. This study compares acellular and erythrocyte-based NMP with focus on oxygen delivery to the tissue as well a…
View article: Successful temporary machine perfusion of marginal liver grafts early after retrieval or shortly before implantation.
Successful temporary machine perfusion of marginal liver grafts early after retrieval or shortly before implantation. Open
Our data suggest that it might not be necessary to hurry with the attempt to connect the graft to a machine early after retrieval.
View article: Controlled oxygenated rewarming as novel end‐ischemic therapy for cold stored liver grafts. A randomized controlled trial
Controlled oxygenated rewarming as novel end‐ischemic therapy for cold stored liver grafts. A randomized controlled trial Open
Abrupt return to normothermia has been shown a genuine factor contributing to graft dysfunction after transplantation. This study tested the concept to mitigate reperfusion injury of liver grafts by gentle warming‐up using ex vivo machine …
View article: Preservation of Mitochondrial Coupling and Renal Function by Controlled Oxygenated Rewarming of Porcine Kidney Grafts
Preservation of Mitochondrial Coupling and Renal Function by Controlled Oxygenated Rewarming of Porcine Kidney Grafts Open
Background: Warm reperfusion after previous cold storage has been shown to have a negative impact on mitochondrial function of organ grafts. Here, we wanted to investigate whether a more controlled warming up of the cold graft by ex vivo m…
View article: Clinical use of controlled oxygenated rewarming of kidney grafts prior to transplantation by ex vivo machine perfusion. A pilot study
Clinical use of controlled oxygenated rewarming of kidney grafts prior to transplantation by ex vivo machine perfusion. A pilot study Open
Background Sudden restoration of normothermic conditions upon reperfusion of cold‐stored grafts has been suggested to entail a massive energy demand not yet met by the cells that still suffer from hypothermic torpor. An adapted and gentle …
View article: Comparison of thermal variations in post‐retrieval graft conditioning on rat livers
Comparison of thermal variations in post‐retrieval graft conditioning on rat livers Open
Background Machine perfusion was found an effective tool to recover organ grafts from ischemic insults during preservation. It could be observed that organ integrity is significantly affected by abrupt temperature shifts during hypothermic…
View article: Oral presentations
Oral presentations Open
Introduction: Controlled oxygenated rewarming of kidney grafts on ex vivo machine perfusion with acellular perfusion solution has been reported to be feasible for reconditioning of marginal grafts.Methods: We conduced small pilot clinic tr…
View article: Impact of Red Blood Cells on Function and Metabolism of Porcine Deceased Donor Kidneys During Normothermic Machine Perfusion
Impact of Red Blood Cells on Function and Metabolism of Porcine Deceased Donor Kidneys During Normothermic Machine Perfusion Open
Background. Normothermic machine perfusion (NMP) protocols using blood-based solutions are commonly used in the assessment of kidneys before transplantation. This procedure is, nevertheless, limited by blood availability and warrants the s…
View article: Controlled Oxygenated Rewarming Compensates for Cold Storage–induced Dysfunction in Kidney Grafts
Controlled Oxygenated Rewarming Compensates for Cold Storage–induced Dysfunction in Kidney Grafts Open
Background. Normothermic machine perfusion (NMP) provides a promising strategy for preservation and conditioning of marginal organ grafts. However, at present, high logistic effort limits normothermic renal perfusion to a short, postponed …
View article: Oxygenated End-Hypothermic Machine Perfusion in Expanded Criteria Donor Kidney Transplant
Oxygenated End-Hypothermic Machine Perfusion in Expanded Criteria Donor Kidney Transplant Open
isrctn.org Identifier: ISRCTN63852508.
View article: Use of the new preservation solution Custodiol‐MP for ex vivo reconditioning of kidney grafts
Use of the new preservation solution Custodiol‐MP for ex vivo reconditioning of kidney grafts Open
Organ shortage and the increasing use of extended criteria donor grafts for transplantation drives efforts for more efficient organ preservation strategies from simple cold storage toward dynamic organ reconditioning. The choice of a suita…
View article: Reduction of Renal Preservation/Reperfusion Injury by Controlled Hyperthermia During <i>Ex Vivo</i> Machine Perfusion
Reduction of Renal Preservation/Reperfusion Injury by Controlled Hyperthermia During <i>Ex Vivo</i> Machine Perfusion Open
The possible reno‐protective effect of a controlled brief heat‐shock treatment during isolated ex vivo machine perfusion of donor grafts prior to reperfusion should be investigated in a primary in vitro study. Porcine kidneys ( n = 14) wer…
View article: Adenosine A2a Receptor Stimulation Attenuates Ischemia-Reperfusion Injury and Improves Survival in A Porcine Model of DCD Liver Transplantation
Adenosine A2a Receptor Stimulation Attenuates Ischemia-Reperfusion Injury and Improves Survival in A Porcine Model of DCD Liver Transplantation Open
Orthotopic liver transplantation (OLT) using allografts from donation after circulatory death (DCD) is potentially associated with compromised clinical outcomes due to ischemia-reperfusion injury (IRI)-induced organ damage and graft-relate…
View article: Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation
Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation Open
Background. Controlled oxygenated rewarming (COR) has been shown to be a feasible and safe method in clinical practice and to reduce peak serum transaminases after liver transplantation. This study aimed to demonstrate further clinical exp…
View article: Effect of oxygen concentration in anterograde liver persufflation on high energy phosphates and graft function after ischemic preservation
Effect of oxygen concentration in anterograde liver persufflation on high energy phosphates and graft function after ischemic preservation Open
Here we evaluate the potential of anterograde gaseous oxygen persufflation for graft reconditioning after extended storage times. Pig livers were retrieved and cold-stored in HTK solution for 16 h. Some grafts were subsequently subjected t…
View article: Bioengineering Liver Transplantation
Bioengineering Liver Transplantation Open
The aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be appl…
View article: Transient hyperthermia during oxygenated rewarming of isolated rat livers
Transient hyperthermia during oxygenated rewarming of isolated rat livers Open
Pretransplant machine perfusion of donor grafts has gained clinical appreciation to improve graft function and survival after transplantation. This study was aimed as pilot investigation to evaluate the additive potential of a transient ex…
View article: First-in-man controlled rewarming and normothermic perfusion with cell-free solution of a kidney prior to transplantation
First-in-man controlled rewarming and normothermic perfusion with cell-free solution of a kidney prior to transplantation Open
View article: Analysis of Data from the Oxygen Persufflation in Liver Transplantation (OPAL) Study to Determine the Role of Factors Affecting the Hepatic Microcirculation and Early Allograft Dysfunction
Analysis of Data from the Oxygen Persufflation in Liver Transplantation (OPAL) Study to Determine the Role of Factors Affecting the Hepatic Microcirculation and Early Allograft Dysfunction Open
BACKGROUND Adequate microcirculatory perfusion is essential for the provision of oxygen to the liver following transplantation. Data from the Oxygen Persufflation in Liver Transplantation (OPAL) study (ISRCTN00167887) were analyzed from li…
View article: Oxygen Persufflation in Liver Transplantation Results of a Randomized Controlled Trial
Oxygen Persufflation in Liver Transplantation Results of a Randomized Controlled Trial Open
Oxygen persufflation has shown experimentally to favorably influence hepatic energy dependent pathways and to improve survival after transplantation. The present trial evaluated oxygen persufflation as adjunct in clinical liver preservatio…
View article: Rewarming Injury after Cold Preservation
Rewarming Injury after Cold Preservation Open
Organ dysfunction pertinent to tissue injury related to ischemic ex vivo preservation during transport from donor to recipient still represents a pivotal impediment in transplantation medicine. Cold storage under anoxic conditions minimize…
View article: Effects of Oxygen During Long-term Hypothermic Machine Perfusion in a Porcine Model of Kidney Donation After Circulatory Death
Effects of Oxygen During Long-term Hypothermic Machine Perfusion in a Porcine Model of Kidney Donation After Circulatory Death Open
Background. Hypothermic machine perfusion (HMP) has become standard care in many center’s to preserve kidneys donated after circulatory death (DCD). Despite a significant reduction in metabolism at low temperatures, the remaining cellular …
View article: Cold flush after dynamic liver preservation protects against ischemic changes upon reperfusion - an experimental study
Cold flush after dynamic liver preservation protects against ischemic changes upon reperfusion - an experimental study Open
Ex vivo machine perfusion of the liver after cold storage has found to be most effective if combined with controlled oxygenated rewarming up to (sub)-normothermia. On disconnection of the warm graft from the machine, most surgeons usually …
View article: Methylene Blue Treatment of Grafts During Cold Ischemia Time Reduces the Risk of Hepatitis C Virus Transmission
Methylene Blue Treatment of Grafts During Cold Ischemia Time Reduces the Risk of Hepatitis C Virus Transmission Open
This proof-of-concept study is a first step to reduce transmission of infectious HCV particles in the transplant setting and might serve as a model for other relevant pathogens.