Thomas Holland
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View article: Sociodemographic associations with AD biomarkers in POINTER, UBRAIN, and ADNI
Sociodemographic associations with AD biomarkers in POINTER, UBRAIN, and ADNI Open
Background In aging and dementia research, the relationships between modifiable risk factors and biomarkers often vary across cohorts. We aim to evaluate the consistency and generalizability of the association between the area deprivation …
View article: Association of neighborhood deprivation with Alzheimer's Disease pathologies, gray matter volume, white matter hyperintensities and cognition by sex, race or ethnicity and APOE4 status in Non‐demented Older Adults
Association of neighborhood deprivation with Alzheimer's Disease pathologies, gray matter volume, white matter hyperintensities and cognition by sex, race or ethnicity and APOE4 status in Non‐demented Older Adults Open
Background Neighborhood socio‐economic conditions may increase Alzheimer's disease (AD) risk through amyloid, tau, atrophy or vascular pathways, potentially varying by genetic risk, race or ethnicity and sex. We examined associations betwe…
View article: Association of neighborhood social and built environment with physical activity in U.S. POINTER
Association of neighborhood social and built environment with physical activity in U.S. POINTER Open
Background Neighborhood social and built environment characteristics may promote physical activity, a modifiable factor for dementia risk, which may in turn promote cognitive and brain health. We explored the associations of the U.S. Natio…
View article: Cognitive Reserve is Associated with Entorhinal Cortex Tau Burden in an Older, Cognitively Unimpaired Clinical Trial Cohort (U.S. POINTER)
Cognitive Reserve is Associated with Entorhinal Cortex Tau Burden in an Older, Cognitively Unimpaired Clinical Trial Cohort (U.S. POINTER) Open
Background High cognitive reserve (CR) is associated with a reduced dementia risk. and better cognitive performance for given levels of Alzheimer's disease (AD) pathology. We hypothesized that CR is associated with baseline amyloid and tau…
View article: Cognitive reserve predicts baseline tau burden in the U.S. POINTER trial imaging cohort
Cognitive reserve predicts baseline tau burden in the U.S. POINTER trial imaging cohort Open
INTRODUCTION Higher cognitive reserve (CR) is associated with reduced dementia risk. We hypothesized that higher CR is associated with less baseline Alzheimer's disease (AD) pathology in the U.S. Study to Protect Brain Health Through Lifes…
View article: MIND Diet and Hippocampal Sclerosis Among Community-Based Older Adults
MIND Diet and Hippocampal Sclerosis Among Community-Based Older Adults Open
Importance Hippocampal sclerosis (HS), defined as severe neuronal loss and astrogliosis in coronal sections of the midhippocampus cornu ammonis 1 or subiculum, is an important pathology associated with limbic-predominant age-related transa…
View article: Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER
Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER Open
INTRODUCTION Validation of the primary cognitive composite and baseline cognitive characteristics are presented for the US‐Study‐to‐Protect‐Brain‐Health‐Through‐Lifestyle‐Intervention‐to‐Reduce‐Risk (US POINTER). METHODS US POINTER is a mu…
View article: Critical Modifying Effect of APOE 4 Allele and Sex on the Prospective Associations between Lipid Species and 10‐year Cognitive Decline in Biracial Community‐dwelling Older Adults: the Chicago Health and Aging Project (CHAP)
Critical Modifying Effect of APOE 4 Allele and Sex on the Prospective Associations between Lipid Species and 10‐year Cognitive Decline in Biracial Community‐dwelling Older Adults: the Chicago Health and Aging Project (CHAP) Open
Background There have been contradictory findings on the associations between lipids and cognitive decline, which could have been attributed to heterogeneity in APOE allele and sex. Method We analyzed a subset of the Chicago Health and Agi…
View article: Association of Chronic Anti‐GERD Medication Usage and Cognitive Decline in a Racially Diverse Elderly Population
Association of Chronic Anti‐GERD Medication Usage and Cognitive Decline in a Racially Diverse Elderly Population Open
Background It is understood that early medical intervention of various diseases, like cardiovascular or gastroenterological, is a potential way to mitigate the progression of cognitive decline and dementia. However, some medications’ mecha…
View article: Cardiovascular health and the risk of Alzheimer’s dementia in a biracial population‐based study
Cardiovascular health and the risk of Alzheimer’s dementia in a biracial population‐based study Open
Background The cardiovascular health (CVH) index, created by the American Heart Association (AHA) to assess and monitor the risk of cardiovascular disease, has been related to dementia risk. However, evidence is limited, and most studies o…
View article: Association of Whole Grain Consumption and Cognitive Decline
Association of Whole Grain Consumption and Cognitive Decline Open
Among AA participants, individuals with higher consumption of whole grains and more frequent consumption of whole grain had slower decline in global cognition, perceptual speed, and episodic memory. We did not see a similar trend in White …
View article: Dietary Sugar Intake Associated with a Higher Risk of Dementia in Community-Dwelling Older Adults
Dietary Sugar Intake Associated with a Higher Risk of Dementia in Community-Dwelling Older Adults Open
Background: We have limited evidence for the relationship of high sugar intake with dementia risk. Objective: To determine whether high sugar intake is associated with an increased risk of dementia in community-dwelling older adults Method…
View article: Cardiovascular health and cognitive outcomes: Findings from a biracial population‐based study in the United States
Cardiovascular health and cognitive outcomes: Findings from a biracial population‐based study in the United States Open
INTRODUCTION The aim of this study was to evaluate the association of cardiovascular health (CVH) with cognitive outcomes, including incident Alzheimer's dementia, rate of cognitive decline, and measures of brain injury and structure. METH…
View article: Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons
Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons Open
Among cognitively unimpaired participants with a family history of dementia, changes in cognition and brain MRI outcomes from baseline to year 3 did not differ significantly between those who followed the MIND diet and those who followed t…
View article: MIND Dietary Pattern and Its Association with Cognition and Incident Dementia in the UK Biobank
MIND Dietary Pattern and Its Association with Cognition and Incident Dementia in the UK Biobank Open
A high adherence to the Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) has been associated with better cognition and a lower risk of dementia in some but not all studies. We measu…
View article: Brain vitamin D forms, cognitive decline, and neuropathology in community‐dwelling older adults
Brain vitamin D forms, cognitive decline, and neuropathology in community‐dwelling older adults Open
Introduction Vitamin D purportedly protects against cognitive decline and dementia based on observational data using circulating 25‐hydroxyvitamin D (25(OH)D). Little is known about vitamin D in the human brain and the association with dem…
View article: Association of Dietary Intake of Flavonols With Changes in Global Cognition and Several Cognitive Abilities
Association of Dietary Intake of Flavonols With Changes in Global Cognition and Several Cognitive Abilities Open
Results suggest that dietary intakes of total flavonols and several flavonol constituents may be associated with slower decline in global cognition and multiple cognitive abilities with older age.
View article: Lifestyle and Cognitive Decline in Community-Dwelling Stroke Survivors
Lifestyle and Cognitive Decline in Community-Dwelling Stroke Survivors Open
Background: Patients with stroke are at a higher risk of cognitive impairment and Alzheimer’s disease dementia. Objective: To quantify the role of lifestyle pre-stroke, post-stroke, and changes in lifestyle before and after stroke with cog…
View article: Pelargonidin and Berry Intake Association with Alzheimer’s Disease Neuropathology: A Community-Based Study
Pelargonidin and Berry Intake Association with Alzheimer’s Disease Neuropathology: A Community-Based Study Open
Background: An anthocyanidin, pelargonidin, primarily found in berries, has antioxidant and anti-inflammatory properties, and is associated with better cognition and reduced Alzheimer’s dementia risk. Objective: This study investigated if …
View article: Healthy lifestyle and life expectancy with and without Alzheimer’s dementia: population based cohort study
Healthy lifestyle and life expectancy with and without Alzheimer’s dementia: population based cohort study Open
Objective To determine the impact of lifestyle factors on life expectancy lived with and without Alzheimer’s dementia. Design Prospective cohort study. Setting The Chicago Health and Aging Project, a population based cohort study in the Un…
View article: Primary prevention recommendations to reduce the risk of cognitive decline
Primary prevention recommendations to reduce the risk of cognitive decline Open
Introduction Few resources address steps clinicians can take to help patients reduce their risk of dementia, despite growing recognition that brain health can be optimized and that risk reduction for cognitive decline can be accomplished b…
View article: Western diet associated with increased post-stroke depressive symptoms
Western diet associated with increased post-stroke depressive symptoms Open
The present study examines the association of diet with depressive symptoms among stroke survivors from a community cohort of older adults. Depression is common after stroke. A healthy diet has previously been associated with fewer depress…
View article: Association of vitamin K with cognitive decline and neuropathology in community‐dwelling older persons
Association of vitamin K with cognitive decline and neuropathology in community‐dwelling older persons Open
Higher vitamin K intakes have been associated with better cognitive function, suggestive of a vitamin K mechanistic effect or simply reflective of a healthy diet. To test the hypothesis that brain vitamin K is linked to cognitive decline a…
View article: Genetic risk, adherence to a healthy lifestyle, and cognitive decline in African Americans and European Americans
Genetic risk, adherence to a healthy lifestyle, and cognitive decline in African Americans and European Americans Open
Introduction We investigated the role of genetic risk and adherence to lifestyle factors on cognitive decline in African Americans and European Americans. Methods Using data from the Chicago Health and Aging Project (1993–2012; n = 3874), …
View article: Free-Living Standing Activity as Assessed by Seismic Accelerometers and Cognitive Function in Community-Dwelling Older Adults: The MIND Trial
Free-Living Standing Activity as Assessed by Seismic Accelerometers and Cognitive Function in Community-Dwelling Older Adults: The MIND Trial Open
Background Few older adults are able to achieve recommended levels of moderate–vigorous physical activity despite known cognitive benefits. Alternatively, less intense activities such as standing can be easily integrated into daily life. N…
View article: Unhealthy foods may attenuate the beneficial relation of a Mediterranean diet to cognitive decline
Unhealthy foods may attenuate the beneficial relation of a Mediterranean diet to cognitive decline Open
Introduction It is unclear whether eating Western diet food components offsets the Mediterranean diet's (MedDiet) potential benefits on cognitive decline. Methods The study includes 5001 Chicago Health and Aging Project participants (63% A…
View article: Dietary intake of the bioactive pelargonidin may slow decline in multiple cognitive abilities
Dietary intake of the bioactive pelargonidin may slow decline in multiple cognitive abilities Open
Background Research has demonstrated a positive relationship between cognitive abilities and dietary intake of flavonoids, bioactives found in foods that have known antioxidant and anti‐inflammatory characteristics. We advance past researc…