Thomas Muenzel
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View article: Psychosocial Work Stress, Resilience and the Risk of Tinnitus—Results from a Population-Based Cohort Study
Psychosocial Work Stress, Resilience and the Risk of Tinnitus—Results from a Population-Based Cohort Study Open
Background and Objectives: Tinnitus is a common symptom in otolaryngologic practice. Although its pathophysiology is multifactorial and remains mostly unclear, it can be correlated to stress and psychological comorbidities. The aim of this…
View article: Assessing Vascular Tone and Fluid Balance in Septic and Cardiogenic Shock: A Feasibility Study on Skin Water Loss as a Diagnostic Tool
Assessing Vascular Tone and Fluid Balance in Septic and Cardiogenic Shock: A Feasibility Study on Skin Water Loss as a Diagnostic Tool Open
Background/Objectives: Fluid management in shock remains a clinical challenge, with ongoing debate about optimal guidance. Despite advanced technologies, fluid balance assessment is often inadequate. The SkInShock study investigated whethe…
View article: Altered Neuroretinal Tissue in Childhood Cancer Survivors: Data From the German CVSS Study
Altered Neuroretinal Tissue in Childhood Cancer Survivors: Data From the German CVSS Study Open
Follow-ups are needed to evaluate if this might result in increased risk for neurodegenerative ophthalmic diseases, like glaucoma.
View article: Incidence of major cardiovascular events in patients with metabolic dysfunction‐associated steatotic liver disease in the general population
Incidence of major cardiovascular events in patients with metabolic dysfunction‐associated steatotic liver disease in the general population Open
Aims Major adverse cardiovascular events (MACE) related to cardiovascular disease are a major cause of death in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). We explored the impact of MASLD on incident MAC…
View article: Nutzung und Nutzen des Betrieblichen Eingliederungsmanagements und der Stufenweisen Wiedereingliederung aus der Sicht von Beschäftigten
Nutzung und Nutzen des Betrieblichen Eingliederungsmanagements und der Stufenweisen Wiedereingliederung aus der Sicht von Beschäftigten Open
Zusammenfassung Hintergrund Mit dem Betrieblichen Eingliederungsmanagement (BEM) und der Stufenweisen Wiedereingliederung (StW) sollen Beschäftigte nach längerer Arbeitsunfähigkeit (AU) unterstützt werden, zur Arbeit zurückzukehren. Unters…
View article: A comprehensive review/expert statement on environmental risk factors of cardiovascular disease
A comprehensive review/expert statement on environmental risk factors of cardiovascular disease Open
Cardiovascular disease (CVD) is the leading cause of mortality globally, with over 20 million deaths each year. While traditional risk factors—such as hypertension, diabetes, smoking, and poor diet—are well-established, emerging evidence u…
View article: Gendered analysis of care work burden and mental health using data from the Gutenberg Covid-19 study
Gendered analysis of care work burden and mental health using data from the Gutenberg Covid-19 study Open
View article: In-hospital course of children with COVID-19 infection - Results of the German nationwide inpatient sample
In-hospital course of children with COVID-19 infection - Results of the German nationwide inpatient sample Open
In Germany in 2020, hospitalized children aged ≤18 years with COVID-19 infection had a low case-fatality. Heart, liver and renal failure were associated with adverse COVID-19 complications, such as the need for mechanical ventilation or de…
View article: Absorb® bioresorbable scaffold in “established” versus “off-label” coronary lesions: 5-year data from the GABI-R® registry
Absorb® bioresorbable scaffold in “established” versus “off-label” coronary lesions: 5-year data from the GABI-R® registry Open
View article: Risk tools for predicting long-term sequelae based on symptom profiles after known and undetected SARS-CoV-2 infections in the population
Risk tools for predicting long-term sequelae based on symptom profiles after known and undetected SARS-CoV-2 infections in the population Open
View article: Role of Heart Rate Recovery in Chronic Heart Failure: Results From the MyoVasc Study
Role of Heart Rate Recovery in Chronic Heart Failure: Results From the MyoVasc Study Open
Background Cardiac autonomic dysfunction is associated with heart failure (HF). Reduced heart rate recovery (HRR) indicates impaired parasympathetic reactivation after physical activity. Heart rate recovery 60 seconds after peak effort (HR…
View article: Proteomic Atlas of Post-COVID Sequelae
Proteomic Atlas of Post-COVID Sequelae Open
The emergence of post-COVID sequelae (PCS) represents a global challenge. However, understanding of biological mechanisms and the definition of quantifiable risk factors remains limited. This study harnessed the power of predictive machine…
View article: The links between soil and water pollution and cardiovascular disease
The links between soil and water pollution and cardiovascular disease Open
Soil and water pollution represent significant threats to global health, ecosystems, and biodiversity. Healthy soils underpin terrestrial ecosystems, supporting food production, biodiversity, water retention, and carbon sequestration. Howe…
View article: Transportation noise and the cardiometabolic risk
Transportation noise and the cardiometabolic risk Open
Transportation noise is a widespread and often underestimated environmental pollutant, posing a substantial health risk particularly in urban areas. In contrast to air pollution, the health effects of noise pollution are less extensively d…
View article: Tinnitus is not associated with cardiovascular risk factors or mortality in the Gutenberg Health Study
Tinnitus is not associated with cardiovascular risk factors or mortality in the Gutenberg Health Study Open
Background and aims Tinnitus, characterized by the conscious perception of sound without external acoustic stimulation, presents a multifaceted challenge. Recent research suggests a potential association between tinnitus and cardiovascular…
View article: Gender-specific changes in vision-related quality of life over time – results from the population-based Gutenberg Health Study
Gender-specific changes in vision-related quality of life over time – results from the population-based Gutenberg Health Study Open
Purpose To investigate potential gender- and age-specific changes over time in vision-related quality of life (VRQoL) on a population-based level. Further, factors associated with changes in VRQoL will be explored. Methods The Gutenberg He…
View article: Personalized app-based coaching for improving physical activity in heart failure with preserved ejection fraction patients compared with standard care: rationale and design of the MyoMobile Study
Personalized app-based coaching for improving physical activity in heart failure with preserved ejection fraction patients compared with standard care: rationale and design of the MyoMobile Study Open
Aims Patients suffering from heart failure with preserved ejection fraction (HFpEF) often exhibit a sedentary lifestyle, contributing to the worsening of their condition. Although there is an inverse relationship between physical activity …
View article: CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension
CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension Open
View article: Altered retinal vasculature in childhood cancer survivors: Data from the German <scp>CVSS</scp>‐study
Altered retinal vasculature in childhood cancer survivors: Data from the German <span>CVSS</span>‐study Open
Aims Childhood cancer is a risk factor for cardiovascular diseases in later life. Retinal examination allows to non‐invasively observe the vasculature of an end‐organ. We observe alterations in long‐term childhood cancer survivors (CCS). M…
View article: Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage
Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage Open
Noise pollution is a known health risk factor and evidence for cardiovascular diseases associated with traffic noise is growing. At least 20% of the European Union’s population lives in noise-polluted areas with exposure levels exceeding t…
View article: Antagonizing IL-17A reduces vascular inflammation and oxidative stress formation but not vascular dysfunction induced by one week of Angiotensin II treatment
Antagonizing IL-17A reduces vascular inflammation and oxidative stress formation but not vascular dysfunction induced by one week of Angiotensin II treatment Open
View article: The Impact of Aircraft Noise Exposure on the Efficacy of Empagliflozin Therapy in an Animal Model of Obesity
The Impact of Aircraft Noise Exposure on the Efficacy of Empagliflozin Therapy in an Animal Model of Obesity Open
Background: Obesity and type 2 diabetes mellitus (T2DM) are among the leading risk factors for mortality worldwide. Sodium-glucose co-transporter 2 Inhibitors (SGLT2i), such as empagliflozin, represent a last-generation drug class for T2DM…
View article: Antagonizing IL-17A reduces vascular inflammation and oxidative stress formation but not vascular dysfunction induced by one week of Angiotensin II treatment
Antagonizing IL-17A reduces vascular inflammation and oxidative stress formation but not vascular dysfunction induced by one week of Angiotensin II treatment Open
View article: 22. Transportation Noise and Cardiovascular Health: Evidence, Mechanisms, and Policy Imperatives
22. Transportation Noise and Cardiovascular Health: Evidence, Mechanisms, and Policy Imperatives Open
Environmental noise, particularly from road, rail, and aircraft traffic, is now firmly recognized as a widespread risk factor for cardiovascular disease. About 1 in 3 Europeans is exposed to chronic noise exposure above the guideline thres…
View article: Mental health symptoms and burdens after a SARS-CoV-2 infection
Mental health symptoms and burdens after a SARS-CoV-2 infection Open
Background Previous studies have found adverse effects on mental health following infection with SARS-CoV-2. This study investigates whether mental health is also impaired in unknowingly infected individuals. In addition, the relevance of …
View article: Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study
Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study Open
Use of systemic selective beta-blockers is associated with an IOP change on a population level, whereas the association with other systemic medications on IOP change could be explained by co-medication use or change in blood pressure. Pati…
View article: Loneliness and social anxiety in the general population over time – results of a cross-lagged panel analysis
Loneliness and social anxiety in the general population over time – results of a cross-lagged panel analysis Open
Background Loneliness has become a major public health issue of the recent decades due to its severe impact on health and mortality. Little is known about the relation between loneliness and social anxiety. This study aimed (1) to explore …
View article: How quitting, switching to e-cigarettes, or sticking to smoking shapes cardiovascular outcomes after percutaneous coronary intervention
How quitting, switching to e-cigarettes, or sticking to smoking shapes cardiovascular outcomes after percutaneous coronary intervention Open
View article: Challenges posed by climate hazards to cardiovascular health and cardiac intensive care: implications for mitigation and adaptation
Challenges posed by climate hazards to cardiovascular health and cardiac intensive care: implications for mitigation and adaptation Open
Global warming, driven by increased greenhouse gas emissions, has led to unprecedented extreme weather events, contributing to higher morbidity and mortality rates from a variety of health conditions, including cardiovascular disease (CVD)…
View article: MyD88 in myeloid cells promotes angiotensin II-induced vascular inflammation and is associated with all-cause mortality and incident heart failure in humans with arterial hypertension
MyD88 in myeloid cells promotes angiotensin II-induced vascular inflammation and is associated with all-cause mortality and incident heart failure in humans with arterial hypertension Open
Background Angiotensin II (AngII) causes hypertension and promotes vascular accumulation of inflammatory cells. We aimed to determine how myeloid factor of differentiation 88 (MyD88) contributes to vascular dysfunction and arterial hyperte…