Thomas F. Murray
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Negative affect interacts with perceptual affective biases Open
BackgroundAffective biases are central to mood and anxiety disorders, with individuals often interpreting ambiguous facial expressions more negatively. Adaptation paradigms - where exposure to emotional stimuli shifts perception - offer a …
Negative affect interacts with perceptual affective biases Open
BackgroundAffective biases are central to mood and anxiety disorders, with individuals often interpreting ambiguous facial expressions more negatively. Adaptation paradigms - where exposure to emotional stimuli shifts perception - offer a …
A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist Open
Kappa opioid receptor (KOR) antagonists have potential therapeutic applications in the treatment of stress-induced relapse to substance abuse and mood disorders. The dynorphin A analog arodyn (Ac[Phe1,2,3,Arg4,D-Ala8]dynorphin A-(1–11)-NH2…
View article: Tryptophan Substitution in CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference
Tryptophan Substitution in CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference Open
The macrocyclic tetrapeptide CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) and its D-Trp isomer exhibit kappa opioid receptor (KOR) antagonism which prevents stress-induced reinstatement of extinguished cocaine-conditioned place preference. Here, w…
Engineering of niobium surfaces through accelerated neutral atom beam technology for quantum applications Open
A major roadblock to scalable quantum computing is phase decoherence and energy relaxation caused by qubits interacting with defect-related two-level systems (TLSs). Native oxides present on the surfaces of superconducting metals used in q…
Engineering of Niobium Surfaces Through Accelerated Neutral Atom Beam Technology For Quantum Applications Open
A major roadblock to scalable quantum computing is phase decoherence and energy relaxation caused by qubits interacting with defect-related two-level systems (TLS). Native oxides present on the surfaces of superconducting metals used in qu…
Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1) Open
N-methyl-D-aspartate (NMDA) receptors play a critical role in activity-dependent dendritic arborization, spinogenesis, and synapse formation by stimulating calcium-dependent signaling pathways. Previously, we have shown that brevetoxin 2 (…
Antillatoxin-Stimulated Neurite Outgrowth Involves the Brain-Derived Neurotrophic Factor (BDNF) - Tropomyosin Related Kinase B (TrkB) Signaling Pathway Open
Voltage-gated sodium channel (VGSC) activators promote neurite outgrowth by augmenting intracellular Na+ concentration ([Na+]i) and upregulating N-methyl-d-aspartate receptor (NMDAR) function. NMDAR activation stimulates calcium (Ca2+) inf…
Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay Open
We explored the utility of the real-time FLIPR Membrane Potential (FMP) assay as a method to assess kappa opioid receptor (KOR)-induced hyperpolarization. The FMP Blue dye was used to measure fluorescent signals reflecting changes in membr…
Computational Predictors in Online Social Deliberations Open
This research seeks to identify online participants’ disposition and skills. A prototype dashboard and annotation scheme were developed to support facilitators and several computational predictors were identified that show statistically si…
Conformational Constraint between Aromatic Residue Side Chains in the “Message” Sequence of the Peptide Arodyn Using Ring Closing Metathesis Results in a Potent and Selective Kappa Opioid Receptor Antagonist Open
Kappa opioid receptor (KOR) antagonists have recently shown potential for treating drug addiction and mood disorders. The linear acetylated dynorphin A analog arodyn (Ac[Phe1,2,3,Arg4,d-Ala8]dynorphin A-(1-11)NH2), synthesized in our labor…
Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles Open
The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo. The present study evaluated the influence of the Phe residues’ stereochem…
Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke Open
Emerging literature suggests that after a stroke, the peri-infarct region exhibits dynamic changes in excitability. In rodent stroke models, treatments that enhance excitability in the peri-infarct cerebral cortex promote motor recovery. T…
Leveraging Affect Transfer Learning for Behavior Prediction in an Intelligent Tutoring System Open
In this work, we propose a video-based transfer learning approach for predicting problem outcomes of students working with an intelligent tutoring system (ITS). By analyzing a student's face and gestures, our method predicts the outcome of…
Comparison of the pharmacologic profiles of arginine vasopressin and oxytocin analogs at marmoset, titi monkey, macaque, and human oxytocin receptors Open
The oxytocin-arginine vasopressin (OT-AVP) ligand-receptor family influences a variety of physiological, behavioral, and social behavioral processes in the brain and periphery. The OT-AVP family is highly conserved in mammals, but recent d…
View article: Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte, <i>Derbesia</i> sp., Using MS/MS-Based Molecular Networking
Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte, <i>Derbesia</i> sp., Using MS/MS-Based Molecular Networking Open
A thiazole-containing cyclic depsipeptide with 11 amino acid residues, named pagoamide A (1), was isolated from laboratory cultures of a marine Chlorophyte, Derbesia sp. This green algal sample was collected from America Samoa, and pagoami…
Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry Open
Identifying neurons that have functional opioid receptors is fundamental for the understanding of the cellular, synaptic and systems actions of opioids. Current techniques are limited to post hoc analyses of fixed tissues. Here we develope…
Author response: Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Identifying neurons that have functional o…
Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. <i>Phormidium</i> sp. Open
Cancer cell cytotoxicity was used to guide the isolation of nine new swinholide-related compounds, named samholides A-I (1-9), from an American Samoan marine cyanobacterium cf. Phormidium sp. Their structures were determined by extensive a…
Comprehensive Study on the Potential Therapeutic Use of Brevetoxin-2 to Aid Post-stroke Recovery Open
OBJECTIVE Stroke triggers changes in neuronal circuits in the peri-infarct area which plays a key role in recovery and represents a potential therapeutic target. Brevetoxin-2 (PbTx-2) interacts with voltage gated sodium channels. Previous …
VOLTAGE-GATED SODIUM CHANNEL ACTIVATION TRIGGERS CALCIUM INFLUX AND HIPPOCAMPAL NEURON COMPLEXITY Open
Background and significance: After stroke, the molecular mechanisms underlying recovery are similar to the development of the nervous system. During development, neuronal activity regulates both the morphology and connectivity of neurons. …
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. <i>Symploca</i> Species Open
A recent untargeted metabolomics investigation into the chemical profile of 10 organic extracts from cf. Symploca spp. revealed several interesting chemical leads for further natural product drug discovery. Subsequent target-directed isola…
Relationships Between Knee Extension Moments During Weighted and Unweighted Gait and Strength Measures That Predict Knee Moments After ACL Reconstruction Open
Background: Weighted gait increases internal knee extension moment impulses (KEMI) in the anterior cruciate ligament–reconstructed (ACLR) limb; however, limb differences persist. Hypotheses: (1) KEMI during normal gait will influence KEMI …
Alanine scan of the opioid peptide dynorphin B amide Open
To date structure‐activity relationship (SAR) studies of the dynorphins (Dyn), endogenous peptides for kappa opioid receptors (KOR), have focused almost exclusively on Dyn A with minimal studies on Dyn B. While both Dyn A and Dyn B have id…
A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium <i>Moorea producens</i> Open
Genome sequencing of microorganisms has revealed a greatly increased capacity for natural products biosynthesis than was previously recognized from compound isolation efforts alone. Hence, new methods are needed for the discovery and descr…
Biomechanical Profiles When Towing a Sled and Wearing a Weighted Vest Once Cleared for Sports Post–ACL Reconstruction Open
Background: Though rehabilitation attempts to correct “stiff knee gait” and control for dynamic limb valgus after anterior cruciate ligament reconstruction (ACLR), impaired biomechanics often persist when an individual is cleared to return…