Thomas Nedungadan
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View article: Total synthesis and biological activity of "carbamorphine": O-to-CH2 replacement in the E-ring of the morphine core structure.
Total synthesis and biological activity of "carbamorphine": O-to-CH2 replacement in the E-ring of the morphine core structure. Open
Morphine is a µ-opioid receptor (MOR) agonist and potent analgesic. However, it displays several side effects including respiratory depression and addiction. Here, we show that a single heavy atom replacement in the morphine core structure…
View article: Total synthesis and biological activity of “carbamorphine”: O-to-CH <sub>2</sub> replacement in the E-ring of the morphine core structure
Total synthesis and biological activity of “carbamorphine”: O-to-CH <sub>2</sub> replacement in the E-ring of the morphine core structure Open
Morphine is a µ-opioid receptor (MOR) agonist and potent analgesic. However, it displays several side effects including respiratory depression and addiction. Here, we show that a single heavy atom replacement in the morphine core structure…