Thomas Nevian
YOU?
Author Swipe
View article: Advancing Human iPSC-Derived Motor Neuron Models Using Glutamatergic Modulators for Synaptic Function Studies
Advancing Human iPSC-Derived Motor Neuron Models Using Glutamatergic Modulators for Synaptic Function Studies Open
Understanding human synapse structure and function at nanoscale resolution requires experimental systems that support both high-quality imaging and robust synaptogenesis. While brain tissue and primary neuronal cultures have been widely us…
View article: Differentiated SH-SY5Y Cells Exhibit Neuronal Features but Lack Synaptic Maturity
Differentiated SH-SY5Y Cells Exhibit Neuronal Features but Lack Synaptic Maturity Open
A vital question in neuroscience is if and how efficiently cellular models may be differentiated into functional neuronal cells in culture. Despite the frequent use of the human neuroblastoma cell line SH-SY5Y, differentiation protocols va…
View article: Top-down modulation of sensory processing and mismatch in the mouse posterior parietal cortex
Top-down modulation of sensory processing and mismatch in the mouse posterior parietal cortex Open
View article: Deregulated ion channels contribute to <i>RHOBTB2</i>-associated developmental and epileptic encephalopathy
Deregulated ion channels contribute to <i>RHOBTB2</i>-associated developmental and epileptic encephalopathy Open
While de novo missense variants in the BTB domains of atypical RhoGTPase RHOBTB2 cause a severe developmental and epileptic encephalopathy, de novo missense variants in the GTPase domain or bi-allelic truncating variants are associated wit…
View article: A cellular mechanism contributing to pain-induced analgesia
A cellular mechanism contributing to pain-induced analgesia Open
The anterior cingulate cortex (ACC) plays a crucial role in the perception of pain. It is consistently activated by noxious stimuli and its hyperactivity in chronic pain indicates plasticity in the local neuronal network. However, the way …
View article: Activity of ventral hippocampal parvalbumin interneurons during anxiety
Activity of ventral hippocampal parvalbumin interneurons during anxiety Open
Anxiety plays a key role in guiding behavior in response to potential threats. Anxiety is mediated by the activation of pyramidal neurons in the ventral hippocampus (vH), whose activity is controlled by GABAergic inhibitory interneurons. H…
View article: Interactive effects of pain and arousal state on heart rate and cortical activity in the mouse anterior cingulate and somatosensory cortices
Interactive effects of pain and arousal state on heart rate and cortical activity in the mouse anterior cingulate and somatosensory cortices Open
Sensory disconnection is a hallmark of sleep, yet the cortex retains some ability to process sensory information. Acute noxious stimulation during sleep increases the heart rate and the likelihood of awakening, indicating that certain mech…
View article: An amygdala-to-cingulate cortex circuit for conflicting choices in chronic pain
An amygdala-to-cingulate cortex circuit for conflicting choices in chronic pain Open
View article: Principles of nociceptive coding in the anterior cingulate cortex
Principles of nociceptive coding in the anterior cingulate cortex Open
The perception of pain is a multidimensional sensory and emotional/affective experience arising from distributed brain activity. However, the involved brain regions are not specific for pain. Thus, how the cortex distinguishes nociception …
View article: Top-down modulation of sensory processing and mismatch in the mouse posterior parietal cortex
Top-down modulation of sensory processing and mismatch in the mouse posterior parietal cortex Open
An important function of the neocortex is to compare sensory feedback stimuli with internal predictions of the outside world and evoke mismatch responses to deviations, thus allowing expectations to be updated. The mechanisms behind sensor…
View article: Pain-induced adaptations in the claustro-cingulate pathway
Pain-induced adaptations in the claustro-cingulate pathway Open
View article: Environmental enrichment promotes resilience to neuropathic pain-induced depression and correlates with decreased excitability of the anterior cingulate cortex
Environmental enrichment promotes resilience to neuropathic pain-induced depression and correlates with decreased excitability of the anterior cingulate cortex Open
Depression is a common comorbidity of chronic pain with many patients being affected. However, efficient pharmacological treatment strategies are still lacking. Therefore, it is desirable to find additional alternative approaches. Environm…
View article: Anxiety-related activity of ventral hippocampal interneurons
Anxiety-related activity of ventral hippocampal interneurons Open
Anxiety is an aversive mood reflecting the anticipation of potential threats. The ventral hippocampus (vH) is a key brain region involved in the genesis of anxiety responses. Recent studies have shown that anxiety is mediated by the activa…
View article: Presynaptic NMDA Receptors Influence Ca2+ Dynamics by Interacting with Voltage-Dependent Calcium Channels during the Induction of Long-Term Depression
Presynaptic NMDA Receptors Influence Ca2+ Dynamics by Interacting with Voltage-Dependent Calcium Channels during the Induction of Long-Term Depression Open
Spike-timing-dependent long-term depression (t-LTD) of glutamatergic layer (L)4-L2/3 synapses in developing neocortex requires activation of astrocytes by endocannabinoids (eCBs), which release glutamate onto presynaptic NMDA receptors (pr…
View article: Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain
Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain Open
View article: Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses
Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses Open
Dendrites shape information flow in neurons. Yet, there is little consensus on the level of spatial complexity at which they operate. Through carefully chosen parameter fits, solvable in the least-squares sense, we obtain accurate reduced …
View article: Author response: Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses
Author response: Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses Open
View article: Cortical representation of pain by stable dedicated neurons and dynamic ensembles
Cortical representation of pain by stable dedicated neurons and dynamic ensembles Open
The perception of pain arises from distributed brain activity triggered by noxious stimuli. However, which patterns of activity make nociception distinct from other salient sensory experiences is still unknown. Using in vivo chronic two-ph…
View article: Efficient Low-Pass Dendro-Somatic Coupling in the Apical Dendrite of Layer 5 Pyramidal Neurons in the Anterior Cingulate Cortex
Efficient Low-Pass Dendro-Somatic Coupling in the Apical Dendrite of Layer 5 Pyramidal Neurons in the Anterior Cingulate Cortex Open
Signal propagation in the dendrites of many neurons, including cortical pyramidal neurons in sensory cortex, is characterized by strong attenuation toward the soma. In contrast, using dual whole-cell recordings from the apical dendrite and…
View article: Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses
Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses Open
Dendrites shape information flow in neurons. Yet, there is little consensus on the level of spatial complexity at which they operate. We present a flexible and fast method to obtain simplified neuron models at any level of complexity. Thro…
View article: Electrical Compartmentalization in Neurons
Electrical Compartmentalization in Neurons Open
The dendritic tree of neurons plays an important role in information processing in the brain. While it is thought that dendrites require independent subunits to perform most of their computations, it is still not understood how they compar…
View article: The brain-penetrant 5-HT 7 receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain
The brain-penetrant 5-HT 7 receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain Open
View article: Mechanisms underlying the induction and expression of spike-timing dependent depression at L4-L2/3 synapses in barrel cortex
Mechanisms underlying the induction and expression of spike-timing dependent depression at L4-L2/3 synapses in barrel cortex Open
View article: Dysfunction of Cortical Dendritic Integration in Neuropathic Pain Reversed by Serotoninergic Neuromodulation
Dysfunction of Cortical Dendritic Integration in Neuropathic Pain Reversed by Serotoninergic Neuromodulation Open