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View article: FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes
FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes Open
BACKGROUND: The fatty acid (FA) transporter CD36 (FA translocase/cluster of differentiation 36) is the gatekeeper of cardiac FA metabolism. Preferential localisation of CD36 to the sarcolemma is one of the initiating cellular responses in …
View article: Simultaneous Detection of <i>Sarcocystis hominis</i>, <i>S. heydorni</i>, and <i>S. sigmoideus</i> in Human Intestinal Sarcocystosis, France, 2021–2024
Simultaneous Detection of <i>Sarcocystis hominis</i>, <i>S. heydorni</i>, and <i>S. sigmoideus</i> in Human Intestinal Sarcocystosis, France, 2021–2024 Open
To elucidate the epidemiology of Sarcocystis spp. parasites in human intestinal infections, we used high-throughput sequencing to investigate human intestinal sarcocystosis cases identified by microscopy in France during 2021-2024. Our res…
View article: Tissue-specific differences in the assembly of mitochondrial Complex I are revealed by a novel ENU mutation in ECSIT
Tissue-specific differences in the assembly of mitochondrial Complex I are revealed by a novel ENU mutation in ECSIT Open
Aims Mitochondrial Complex I assembly (MCIA) is a multi-step process that necessitates the involvement of a variety of assembly factors and chaperones to ensure that the final active enzyme is correctly assembled. The role of the assembly …
View article: Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia–reperfusion injury
Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia–reperfusion injury Open
Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide (NO) synthases in which its production of NO is crucial for cardiac function. However, non‐canonical roles of BH4 have been discovered recently and the cell‐specific role …
View article: Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation
Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation Open
Peroxisomal fatty acid α-oxidation is an essential pathway for the degradation of β-carbon methylated fatty acids such as phytanic acid. One enzyme in this pathway is 2-hydroxyacyl CoA lyase (HACL1), which is responsible for the cleavage o…
View article: Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine
Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine Open
Inflammation is a critical component of cardiovascular disease (CVD), encompassing coronary artery disease (CAD), cerebrovascular events and heart failure and is the leading cause of mortality worldwide. In recent years, metabolism has bee…
View article: Linking the <i>FTO</i> obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo
Linking the <i>FTO</i> obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo Open
The obesity-linked FTO regulatory circuitry shows cross-species molecular, cellular, metabolic, and organismal conservation.
View article: Chronically elevated branched chain amino acid levels are pro-arrhythmic
Chronically elevated branched chain amino acid levels are pro-arrhythmic Open
Aims Cardiac arrhythmias comprise a major health and economic burden and are associated with significant morbidity and mortality, including cardiac failure, stroke, and sudden cardiac death (SCD). Development of efficient preventive and th…
View article: Tissue specific requirements for ECSIT in mitochondrial complex I assembly
Tissue specific requirements for ECSIT in mitochondrial complex I assembly Open
Here we describe a mutation in the mitochondrial complex I assembly factor (Evolutionarily conserved signalling intermediate in Toll pathway) ECSIT which reveals tissue specific requirements for this factor in complex I assembly. Mitochond…
View article: Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology
Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology Open
Macrophages are mononuclear phagocytes derived from haematopoietic progenitors that are widely distributed throughout the body. These cells participate in both innate and adaptive immune responses and lie central to the processes of inflam…
View article: T3 Cardiac arrhythmia resulting from an accumulation of branched chain amino acids in a mouse line with a mutation in bcat2
T3 Cardiac arrhythmia resulting from an accumulation of branched chain amino acids in a mouse line with a mutation in bcat2 Open
As part of a large-scale phenotype-driven screen we identified a line exhibiting sudden death. Mapping and whole genome sequencing identified a missense mutation in the Bcat2 gene, encoding mitochondrial branched chained aminotransferase, …
View article: P12 A novel model of cardiomyopathy reveals a tissue specific role for the complex i assembly factor ecsit
P12 A novel model of cardiomyopathy reveals a tissue specific role for the complex i assembly factor ecsit Open
Here we present a mouse model with a missense mutation in the gene Ecsit that shows a progressive cardiomyopathy from 4 weeks of age with no other overt phenotypes. ECSIT is known to play a role in development and immune signalling but is …
View article: The Role of ECSIT in Mitochondrial Dysfunction Mediated Cardiomyopathy
The Role of ECSIT in Mitochondrial Dysfunction Mediated Cardiomyopathy Open
The evolutionarily conserved signalling intermediate in the toll pathway (ECSIT) is a 50 kDa protein involved in the function of many pathways and implicated in a variety of phenotypes. It functions as part of the toll pathway by integrati…