Thomas O. Moninger
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View article: Heterozygous KRT32 variant is responsible for autosomal dominant loose anagen hair syndrome
Heterozygous KRT32 variant is responsible for autosomal dominant loose anagen hair syndrome Open
Loose anagen hair syndrome is a form of childhood-onset non-scarring alopecia marked by easily and painlessly plucking terminal hair during its active growth, or anagen, phase. It is believed to result from poor hair shaft anchoring within…
View article: Heterozygous<i>KRT32</i>variant is responsible for autosomal dominant loose anagen hair syndrome
Heterozygous<i>KRT32</i>variant is responsible for autosomal dominant loose anagen hair syndrome Open
Loose Anagen Hair Syndrome is a form of non-scarring alopecia marked by easily and painlessly pluckable terminal hair during its active growth – anagen – phase. This condition is believed to result from poor hair shaft anchoring within the…
View article: Glutathione peroxidase 4 overexpression induces anomalous subdiffusion and impairs glioblastoma cell growth
Glutathione peroxidase 4 overexpression induces anomalous subdiffusion and impairs glioblastoma cell growth Open
Glioblastoma tumors are the most common and aggressive adult central nervous system malignancy. Nearly all patients experience disease progression, which significantly contributes to disease mortality. Recently, it has been suggested that …
View article: Development and Initial Characterization of Pigs with<i>DNAI1</i>Mutations and Primary Ciliary Dyskinesia
Development and Initial Characterization of Pigs with<i>DNAI1</i>Mutations and Primary Ciliary Dyskinesia Open
Mutations in more than 50 different genes cause primary ciliary dyskinesia (PCD) by disrupting the activity of motile cilia that facilitate mucociliary transport (MCT). Knowledge of PCD has come from studies identifying disease-causing mut…
View article: Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage
Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage Open
Apical cilia on epithelial cells defend the lung by propelling pathogens and particulates out of the respiratory airways. Ciliated cells produce ATP that powers cilia beating by densely grouping mitochondria just beneath the apical membran…
View article: 169 MUC5B and MUC5AC are both required for effective airway mucociliary clearance in ferrets
169 MUC5B and MUC5AC are both required for effective airway mucociliary clearance in ferrets Open
View article: Utilization of commercial collagens for preparing well-differentiated human beta cells for confocal microscopy
Utilization of commercial collagens for preparing well-differentiated human beta cells for confocal microscopy Open
Introduction With technical advances, confocal and super-resolution microscopy have become powerful tools to dissect cellular pathophysiology. Cell attachment to glass surfaces compatible with advanced imaging is critical prerequisite but …
View article: ISG15-modification of the Arp2/3 complex restricts pathogen spread
ISG15-modification of the Arp2/3 complex restricts pathogen spread Open
Summary The ubiquitin-like protein, ISG15, can act as a cytokine or can covalently modify host and pathogen-derived proteins. The consequences of ISG15 modification on substrate fate remain unknown. Here we reveal that ISGylation of the Ar…
View article: Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction
Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction Open
View article: Zinc protoporphyrin binding to telomerase complexes and inhibition of telomerase activity*
Zinc protoporphyrin binding to telomerase complexes and inhibition of telomerase activity* Open
Zinc protoporphyrin (ZnPP), a naturally occurring metalloprotoporphyrin (MPP), is currently under development as a chemotherapeutic agent although its mechanism is unclear. When tested against other MPPs, ZnPP was the most effective DNA sy…
View article: Zinc Protoporphyrin Binding to Telomerase Complexes and Inhibition of Telomerase Activity
Zinc Protoporphyrin Binding to Telomerase Complexes and Inhibition of Telomerase Activity Open
Background: Zinc protoporphyrin (ZnPP) is a naturally occurring metalloprotoporphyrin (MPP) that is currently under development as a chemotherapeutic agent although its mechanism is unclear. Similar to natural and synthetic porphyrins, MPP…
View article: The Chlamydia trachomatis secreted effector TmeA hijacks the N-WASP-ARP2/3 actin remodeling axis to facilitate cellular invasion
The Chlamydia trachomatis secreted effector TmeA hijacks the N-WASP-ARP2/3 actin remodeling axis to facilitate cellular invasion Open
As an obligate intracellular pathogen, host cell invasion is paramount to Chlamydia trachomatis proliferation. While the mechanistic underpinnings of this essential process remain ill-defined, it is predicted to involve delivery of prepack…
View article: Acidic Submucosal Gland pH and Elevated Protein Concentration Produce Abnormal Cystic Fibrosis Mucus
Acidic Submucosal Gland pH and Elevated Protein Concentration Produce Abnormal Cystic Fibrosis Mucus Open
View article: Exocytosis of Progeny Infectious Varicella-Zoster Virus Particles via a Mannose-6-Phosphate Receptor Pathway without Xenophagy following Secondary Envelopment
Exocytosis of Progeny Infectious Varicella-Zoster Virus Particles via a Mannose-6-Phosphate Receptor Pathway without Xenophagy following Secondary Envelopment Open
The long-term goal of this research has been to determine why VZV, when grown in cultured cells, invariably is more cell associated and has a lower titer than other alphaherpesviruses, such as herpes simplex virus 1 (HSV1) or pseudorabies …
View article: Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling
Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling Open
Significance Previous studies localized the hedgehog (HH) signaling system to primary cilia. We discovered that motile cilia on airway epithelia also contain HH signaling proteins, indicating that like primary cilia, these motile cilia hav…
View article: Gel-forming mucins form distinct morphologic structures in airways
Gel-forming mucins form distinct morphologic structures in airways Open
Significance Mucus propelled by cilia is key for removing particulates from lungs by mucociliary transport. The major structural components of airway mucus are two gel-forming mucins, MUC5B and MUC5AC. These mucins exhibit distinct morphol…
View article: HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human Hepatocytes
HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human Hepatocytes Open
HCV infection induces TERT expression and stimulates telomerase activity in addition to triggering Caspase activity that leads to increased TERT degradation. These activities suggest multiple points whereby the virus can influence neoplasi…
View article: Acidic pH increases airway surface liquid viscosity in cystic fibrosis
Acidic pH increases airway surface liquid viscosity in cystic fibrosis Open
Cystic fibrosis (CF) disrupts respiratory host defenses, allowing bacterial infection, inflammation, and mucus accumulation to progressively destroy the lungs. Our previous studies revealed that mucus with abnormal behavior impaired mucoci…