Thomas Oellerich
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View article: P05.14.B MULTI-LAYERED CEREBROSPINAL FLUID LIQUID BIOPSY OF INFLAMMATORY AND ONCOLOGICAL CNS DISEASES
P05.14.B MULTI-LAYERED CEREBROSPINAL FLUID LIQUID BIOPSY OF INFLAMMATORY AND ONCOLOGICAL CNS DISEASES Open
BACKGROUND For diagnosis of central nervous system (CNS) pathologies, invasive procedures such as tissue biopsies are often indicated. The use of cerebrospinal fluid (CSF) for a liquid biopsy (LB) has promise as a minimal invasive tool, no…
View article: Clonal evolution and apoptosis resistance in myelodysplastic neoplasms and acute myeloid leukemia under treatment: insights from integrative longitudinal profiling
Clonal evolution and apoptosis resistance in myelodysplastic neoplasms and acute myeloid leukemia under treatment: insights from integrative longitudinal profiling Open
View article: A pooled analysis of 3 large multicenter trials confirms a survival advantage for <i>NPM1</i> <sup>mut</sup> AML in MRD <sup>neg</sup> remission after intensive induction
A pooled analysis of 3 large multicenter trials confirms a survival advantage for <i>NPM1</i> <sup>mut</sup> AML in MRD <sup>neg</sup> remission after intensive induction Open
View article: Chromatin Perturbation Promotes Susceptibility to Hypomethylating Agents
Chromatin Perturbation Promotes Susceptibility to Hypomethylating Agents Open
Cancer-directed drugs are often clinically deployed without definitive understanding of their molecular mechanisms of action (MOA). Hypomethylating agents (HMAs), which result in the degradation of the DNA methyltransferase 1 (DNMT1), have…
View article: Genetic lesions in nodular lymphocyte-predominant Hodgkin lymphoma and T cell/histiocyte-rich large B-cell lymphoma identified by whole genome sequencing
Genetic lesions in nodular lymphocyte-predominant Hodgkin lymphoma and T cell/histiocyte-rich large B-cell lymphoma identified by whole genome sequencing Open
View article: JAK2 signalling to HNRNPA1 represses retrotransposon activity in haematopoietic stem cells
JAK2 signalling to HNRNPA1 represses retrotransposon activity in haematopoietic stem cells Open
Retrotransposon expression must be tightly controlled, particularly in long-lived multipotent stem cells, to prevent deleterious consequences including insertional mutations. Several mechanisms are known to repress retrotransposon transcri…
View article: Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase
Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase Open
The bifunctional soluble epoxide hydrolase (sEH) represents a promising target for inflammation-related diseases. Although potent inhibitors targeting each domain are available, sEH-PROTACs offer the unique ability to simultaneously block …
View article: Engineered AAV9 as <i>in vivo</i> gene delivery platform for the selective transduction of TME cell subsets
Engineered AAV9 as <i>in vivo</i> gene delivery platform for the selective transduction of TME cell subsets Open
Precise in vivo gene delivery to specific cell types remains a significant challenge in gene therapy, particularly for cancer immunotherapy applications. Here, we rationally engineered AAV9 to become a modular, receptor-targeted vector for…
View article: CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma
CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma Open
Despite the improvement, approximately 60% of patients with relapsed or refractory (r/r) aggressive B cell lymphoma (B-NHL) do not achieve durable benefit from CAR-T cell therapy. To elucidate factors associated with CAR-T therapy resistan…
View article: 327 | LONG‐TERM OUTCOME OF PATIENTS WITH RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA ACHIEVING CR USING BISPECIFIC ANTIBODIES
327 | LONG‐TERM OUTCOME OF PATIENTS WITH RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA ACHIEVING CR USING BISPECIFIC ANTIBODIES Open
View article: Immune responses after one versus two Influenza A/B vaccinations in patients with multiple myeloma
Immune responses after one versus two Influenza A/B vaccinations in patients with multiple myeloma Open
Seasonal Influenza A/B vaccination is routinely administered in patients with Multiple Myeloma (MM) given their disease-and therapy-associated immunosuppression and risk of infection. Previous data show poor seroconversion rates after one …
View article: Inflammatory signaling pathways play a role in SYK inhibitor resistant AML
Inflammatory signaling pathways play a role in SYK inhibitor resistant AML Open
Trials have shown promising clinical activity of the selective SYK inhibitor entospletinib in patients with high expressing HOXA9/MEIS1 acute leukemias. As the development of resistance mechanisms is a common problem in the use of targeted…
View article: Epidemiology and outcomes of Candida spp. bloodstream infections in cancer patients: a comparative retrospective study from a German tertiary cancer center
Epidemiology and outcomes of Candida spp. bloodstream infections in cancer patients: a comparative retrospective study from a German tertiary cancer center Open
View article: GeneCOCOA: Detecting context-specific functions of individual genes using co-expression data
GeneCOCOA: Detecting context-specific functions of individual genes using co-expression data Open
Extraction of meaningful biological insight from gene expression profiling often focuses on the identification of statistically enriched terms or pathways. These methods typically use gene sets as input data, and subsequently return overre…
View article: Efficacy and safety of immune checkpoint inhibition combined with concurrent chemoradiotherapy in patients with stage III unresectable non-small cell lung cancer: A systematic review and meta-analysis
Efficacy and safety of immune checkpoint inhibition combined with concurrent chemoradiotherapy in patients with stage III unresectable non-small cell lung cancer: A systematic review and meta-analysis Open
Addition of single-agent CPI to cCRT is manageable in selected patients with stage III NSCLC. Efficacy outcomes appear to be in line with previous data of cCRT followed by CPI maintenance.
View article: Central nervous system relapse after allogeneic HCT in FLT3-mutated AML
Central nervous system relapse after allogeneic HCT in FLT3-mutated AML Open
View article: AMBRA1 controls the translation of immune-specific genes in T lymphocytes
AMBRA1 controls the translation of immune-specific genes in T lymphocytes Open
T cell receptor (TCR) engagement causes a global cellular response that entrains signaling pathways, cell cycle regulation, and cell death. The molecular regulation of mRNA translation in these processes is poorly understood. Using a whole…
View article: Phosphoproteomic Analysis of Signaling Pathways in Lymphomas
Phosphoproteomic Analysis of Signaling Pathways in Lymphomas Open
Cellular fate is regulated by intricate signal transduction mediated by posttranslational protein modifications like phosphorylation to transmit information. As other cancer types, lymphomas frequently show dysregulation of signaling pathw…
View article: Central nervous system relapse after allogeneic HCT in FLT3-mutated AML
Central nervous system relapse after allogeneic HCT in FLT3-mutated AML Open
Central nervous system (CNS) relapse in acute myeloid leukemia (AML) is rare, but prognostically extremely unfavorable and associated with very high mortality rates. Aim of our single-center study was to define risk factors for CNS relapse…
View article: Supplementary Table S2 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Table S2 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Disease score with corresponding features for the top disease per gene
View article: Supplementary Table S1 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Table S1 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Candidate gene list of selective dependencies identified analyzing DepMap dependency screen data
View article: Supplementary Figure S8 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S8 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
ATP1B1 expression across hematopoietic lineages
View article: Supplementary Figure S2 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S2 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
KO validation using TIDE PCR and cell cycle analysis
View article: Supplementary Material from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Material from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Merged file_supplementary figures and tables with legend
View article: Supplementary Table S3 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Table S3 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
MV4-11 and NB4 BioID_ATP1B1 and BioID_ATP1B3 results
View article: Supplementary Figure S9 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S9 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
ATP1B1 expression in CCLE highlighting Ewing sarcoma cell lines
View article: Supplementary Figure S10 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S10 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Cell viability assay in OCI-AML3 CTRL and TP53-KO cells treated with Nutlin-3.
View article: Supplementary Figure S4 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S4 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
NB4_BioID results
View article: Supplementary Figure S1 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S1 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Candidate gene selection based on the introduced features
View article: Supplementary Figure S7 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S7 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Isoform expression of ATP1B1