Thomas Olender
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View article: Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks
Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks Open
Although certain human genetic variants are conspicuously loss of function, decoding the impact of many variants is challenging. Previously, we described a patient with leukemia predisposition syndrome (GATA2 deficiency) with a germline GA…
View article: <i>Pten</i> regulates endocytic trafficking of cell adhesion and signaling molecules to pattern the retina
<i>Pten</i> regulates endocytic trafficking of cell adhesion and signaling molecules to pattern the retina Open
SUMMARY The retina is an exquisitely patterned tissue, with neuronal somata positioned at regular intervals to completely sample the visual field. Cholinergic amacrine cells are spectacular exemplars of precision, distributing in two radia…
View article: SMPD3-mediated extracellular vesicle biogenesis inhibits oligodendroglioma growth
SMPD3-mediated extracellular vesicle biogenesis inhibits oligodendroglioma growth Open
Oligodendrogliomas are lower-grade, slow-growing gliomas that are ultimately fatal. Although driver mutations are known, the mechanisms underlying their signature slow growth rates are poorly understood. We found evidence for intra-tumoral…
View article: <i>SMPD3</i>suppresses IDH mutant tumor growth via dual autocrine-paracrine roles
<i>SMPD3</i>suppresses IDH mutant tumor growth via dual autocrine-paracrine roles Open
Isocitrate dehydrogenase (IDH) mutant gliomas, including oligodendroglioma (IDH-O) and astrocytoma (IDH-A), have signature slow-growth rates that are poorly understood. Here, we reveal that SMPD3, a ceramide-producing sphingomyelinase impl…
View article: A non-canonical role for the proneural gene<i>Neurog1</i>as a negative regulator of neocortical neurogenesis
A non-canonical role for the proneural gene<i>Neurog1</i>as a negative regulator of neocortical neurogenesis Open
Neural progenitors undergo temporal identity transitions to sequentially generate the neuronal and glial cells that make up the mature brain. Proneural genes have well characterized roles in promoting neural cell differentiation and subtyp…