Thomas P. Conrads
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View article: Quantitative proteomics identifies conserved proteins and altered regulation of mucin-16 in low grade serous ovarian cancers
Quantitative proteomics identifies conserved proteins and altered regulation of mucin-16 in low grade serous ovarian cancers Open
Our efforts define highly conserved protein alterations distinguishing LGSOC from HGSOC tumors, including CD73, as well as the novel identification that MUC16 is elevated and exhibits more apical staining pattern in LGSOC tumor tissues. Th…
View article: Proteogenomic characterization of invasive breast tumors in young women
Proteogenomic characterization of invasive breast tumors in young women Open
View article: Long-Term Survival in Patients With Low-Risk Cervical Cancer After Simple, Modified, or Radical Hysterectomy
Long-Term Survival in Patients With Low-Risk Cervical Cancer After Simple, Modified, or Radical Hysterectomy Open
Importance Three-year pelvic recurrence rate in women with low-risk cervical carcinoma was not inferior following simple hysterectomy (SH) vs modified radical hysterectomy (MRH) or radical hysterectomy (RH) in the Simple Hysterectomy and P…
View article: The dynamic immune behavior of primary and metastatic ovarian carcinoma
The dynamic immune behavior of primary and metastatic ovarian carcinoma Open
View article: Histology-resolved proteomics reveals distinct tumor and stromal profiles in low- and high-grade prostate cancer
Histology-resolved proteomics reveals distinct tumor and stromal profiles in low- and high-grade prostate cancer Open
View article: Real-time functional proteomics enhances therapeutic targeting in precision oncology molecular tumor boards
Real-time functional proteomics enhances therapeutic targeting in precision oncology molecular tumor boards Open
View article: Circulating extracellular vesicles protein expression for early prediction of platinum-resistance in high-grade serous ovarian cancer
Circulating extracellular vesicles protein expression for early prediction of platinum-resistance in high-grade serous ovarian cancer Open
Platinum resistance in high-grade serous ovarian carcinoma (HGSOC) portends a poor prognosis. Although initial platinum-based chemotherapy response rates are high, 15-20% of patients demonstrate primary resistance to platinum therapy and a…
View article: Modeling reproductive and pregnancy-associated tissues using organ-on-chip platforms: challenges, limitations, and the high throughput data frontier
Modeling reproductive and pregnancy-associated tissues using organ-on-chip platforms: challenges, limitations, and the high throughput data frontier Open
Over the past decade, organ-on-chip technology (microphysiological systems or tissue chips) has reshaped in-vitro physiological and pathological modeling and pharmaceutical drug assessment. FDA Modernization Act 2.0 allows for alternatives…
View article: Chemoproteomic analysis reveals RECQL4 as a mediator of nitroalkene-dependent double-strand break repair inhibition in cancer.
Chemoproteomic analysis reveals RECQL4 as a mediator of nitroalkene-dependent double-strand break repair inhibition in cancer. Open
View article: dia-PASEF Proteomics of Tumor and Stroma LMD Enriched from Archived HNSCC Samples
dia-PASEF Proteomics of Tumor and Stroma LMD Enriched from Archived HNSCC Samples Open
We employed laser microdissection to selectively harvest histology-resolved tumors and stroma from formalin-fixed, paraffin-embedded head and neck squamous cell carcinoma (HNSCC) tissues. Peptide digests from the LMD-enriched HNSCC tissue …
View article: Integrating Functional Protein Drug Target Data into a Precision Oncology Molecular Tumor Board
Integrating Functional Protein Drug Target Data into a Precision Oncology Molecular Tumor Board Open
Collaborative review of molecular profiling data by multidisciplinary molecular tumor boards (MTB) is increasingly important for improving patient management and outcomes, though currently relies nearly exclusively on nucleic acid next-gen…
View article: Proteomics based selection achieves complete response to HER2 therapy in HER2 IHC 0 breast cancer
Proteomics based selection achieves complete response to HER2 therapy in HER2 IHC 0 breast cancer Open
Recent trials have shown the efficacy of trastuzumab deruxtecan (T-DXd) in HER2-negative patients, but there is not yet a way to identify which patients will best respond, especially with the inability of current HER2 IHC and FISH assays t…
View article: dia-PASEF Proteomics of Tumor and Stroma LMD Enriched from Archived HNSCC Samples
dia-PASEF Proteomics of Tumor and Stroma LMD Enriched from Archived HNSCC Samples Open
We employed laser microdissection to selectively harvest tumor cells and stroma from the microenvironment of formalin-fixed, paraffin-embedded head and neck squamous cell carcinoma (HNSCC) tissues. The captured HNSCC tissue fractions were …
View article: A modified dual preparatory method for improved isolation of nucleic acids from laser microdissected fresh-frozen human cancer tissue specimens
A modified dual preparatory method for improved isolation of nucleic acids from laser microdissected fresh-frozen human cancer tissue specimens Open
A central theme in cancer research is to increase our understanding of the cancer tissue microenvironment (TME), which is comprised of a complex and spatially heterogeneous ecosystem of malignant and non-malignant cells, both of which acti…
View article: Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities
Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities Open
View article: Author Correction: Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities
Author Correction: Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities Open
View article: Deep Quantitative Proteomics Identifies Conserved Proteome Alterations in Low and High-Grade Serous Ovarian Cancers
Deep Quantitative Proteomics Identifies Conserved Proteome Alterations in Low and High-Grade Serous Ovarian Cancers Open
Low-grade serous ovarian carcinoma (LGSOC) is a rare and largely chemoresistant subtype of epithelial ovarian cancer. Unlike treatment for high-grade serous ovarian cancer (HGSOC), management options for LGSOC patients are limited, in part…
View article: Quantitative proteomic analysis of HER2 protein expression in PDAC tumors
Quantitative proteomic analysis of HER2 protein expression in PDAC tumors Open
Metastatic pancreatic adenocarcinoma (PDAC) is the third leading cause of cancer-related death in the United States, with a 5-year survival rate of only 11%, necessitating identification of novel treatment paradigms. Tumor tissue specimens…
View article: Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities
Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities Open
View article: Immuno-Molecular Targeted Therapy Use and Survival Benefit in Patients with Stage IVB Cervical Carcinoma in Commission on Cancer®-Accredited Facilities in the United States
Immuno-Molecular Targeted Therapy Use and Survival Benefit in Patients with Stage IVB Cervical Carcinoma in Commission on Cancer®-Accredited Facilities in the United States Open
Purpose: To investigate IMT use and survival in real-world stage IVB cervical cancer patients outside randomized clinical trials. Methods: Patients diagnosed with stage IVB cervical cancer during 2013–2019 in the National Cancer Database a…
View article: Microenvironment Shapes Small Cell Lung Cancer Neuroendocrine States and Presents Therapeutic Opportunities
Microenvironment Shapes Small Cell Lung Cancer Neuroendocrine States and Presents Therapeutic Opportunities Open
Summary Small-cell lung cancer (SCLC) is the most fatal form of lung cancer. Intra-tumoral heterogeneity, marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell states, defines SCLC, but the drivers of SCLC plasticity are poorl…
View article: ProteoMixture: A cell type deconvolution tool for bulk tissue proteomic data
ProteoMixture: A cell type deconvolution tool for bulk tissue proteomic data Open
Numerous multi-omic investigations of cancer tissue have documented varying and poor pairwise transcript:protein quantitative correlations, and most deconvolution tools aiming to predict cell type proportions (cell admixture) have been dev…
View article: Survival disparities in non-Hispanic Black and White cervical cancer patients vary by histology and are largely explained by modifiable factors
Survival disparities in non-Hispanic Black and White cervical cancer patients vary by histology and are largely explained by modifiable factors Open
View article: Mapping three-dimensional intratumor proteomic heterogeneity in uterine serous carcinoma by multiregion microsampling
Mapping three-dimensional intratumor proteomic heterogeneity in uterine serous carcinoma by multiregion microsampling Open
Background Although uterine serous carcinoma (USC) represents a small proportion of all uterine cancer cases, patients with this aggressive subtype typically have high rates of chemotherapy resistance and disease recurrence that collective…
View article: A modified dual preparatory method for improved isolation of nucleic acids from laser microdissected fresh-frozen human cancer tissue specimens
A modified dual preparatory method for improved isolation of nucleic acids from laser microdissected fresh-frozen human cancer tissue specimens Open
A central theme in cancer research is to increase our understanding of the cancer tissue microenvironment, which is comprised of a complex and spatially heterogeneous ecosystem of malignant and non-malignant cells, both of which actively c…
View article: Deep learning-based segmentation of multisite disease in ovarian cancer
Deep learning-based segmentation of multisite disease in ovarian cancer Open
View article: Author Correction: Automated imaging and identification of proteoforms directly from ovarian cancer tissue
Author Correction: Automated imaging and identification of proteoforms directly from ovarian cancer tissue Open
Tumor Stroma automated MS² 240 pixels MIF AT5G2
View article: In situ profiling reveals metabolic alterations in the tumor microenvironment of ovarian cancer after chemotherapy
In situ profiling reveals metabolic alterations in the tumor microenvironment of ovarian cancer after chemotherapy Open
In this study, we investigated the metabolic alterations associated with clinical response to chemotherapy in patients with ovarian cancer. Pre- and post-neoadjuvant chemotherapy (NACT) tissues from patients with high-grade serous ovarian …
View article: The murine metastatic microenvironment of experimental brain metastases of breast cancer differs by host age in vivo: a proteomic study
The murine metastatic microenvironment of experimental brain metastases of breast cancer differs by host age in vivo: a proteomic study Open
View article: Automated imaging and identification of proteoforms directly from ovarian cancer tissue
Automated imaging and identification of proteoforms directly from ovarian cancer tissue Open