Edward T. Parkin
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View article: A multi-omic liquid biopsy for the earlier detection of colorectal cancer
A multi-omic liquid biopsy for the earlier detection of colorectal cancer Open
Timely diagnosis and intervention in colorectal cancer (CRC) are critical to improving patient outcomes and limiting disease progression. Screening of average-risk individuals is essential for detecting tumors at an earlier, more treatable…
View article: Therapeutic Role of Functional Massage in Attenuating Exercise-Induced Neuromuscular Fatigue
Therapeutic Role of Functional Massage in Attenuating Exercise-Induced Neuromuscular Fatigue Open
Background: Functional massage is a soft tissue intervention that combines tissue compression with specific joint movements to enhance muscle function, improve joint mobility and reduce pain. The physical working capacity at the fatigue th…
View article: The Core Outcome measures in Squamous Intraepithelial precursor lesions of the Anus (COrSIcA) study: A protocol for the development of a core outcome set for future anal high-grade squamous intraepithelial lesion (aHSIL) treatment trials
The Core Outcome measures in Squamous Intraepithelial precursor lesions of the Anus (COrSIcA) study: A protocol for the development of a core outcome set for future anal high-grade squamous intraepithelial lesion (aHSIL) treatment trials Open
Introduction There are multiple treatments for anal high-grade squamous intraepithelial lesion (aHSIL). The evidence for aHSIL treatments is scarce and of poor quality, such that the optimal approach cannot be defined. Existing trials in a…
View article: Progress towards understanding risk factor mechanisms in the development of autism spectrum disorders
Progress towards understanding risk factor mechanisms in the development of autism spectrum disorders Open
Autism spectrum disorders (ASD) are a heterogenous set of syndromes characterised by social impairment and cognitive symptoms. Currently, there are limited treatment options available to help people with ASD manage their symptoms. Understa…
View article: Liposome nanoparticle conjugation and cell penetrating peptide sequences (<scp>CPPs</scp>) enhance the cellular delivery of the tau aggregation inhibitor <scp>RI</scp>‐<scp>AG03</scp>
Liposome nanoparticle conjugation and cell penetrating peptide sequences (<span>CPPs</span>) enhance the cellular delivery of the tau aggregation inhibitor <span>RI</span>‐<span>AG03</span> Open
Given the pathological role of Tau aggregation in Alzheimer's disease (AD), our laboratory previously developed the novel Tau aggregation inhibitor peptide, RI‐AG03. As Tau aggregates accumulate intracellularly, it is essential that the pe…
View article: 585 Surgical Excision of Isolated Gastrointestinal Metastasis from Malignant Melanoma – a 10-Year Survey
585 Surgical Excision of Isolated Gastrointestinal Metastasis from Malignant Melanoma – a 10-Year Survey Open
Aim Patients with malignant melanoma (MM) can develop isolated metastasis years after treatment of the primary. The spleen and small bowel are the recognised intra-abdominal sites of isolated metastasis. Excision of these metastases is rec…
View article: Liposome Nanoparticle Conjugation and Cell Penetrating Peptide Sequences (CPPs) Enhance the Cellular Delivery of the Tau Aggregation Inhibitor RI-AG03
Liposome Nanoparticle Conjugation and Cell Penetrating Peptide Sequences (CPPs) Enhance the Cellular Delivery of the Tau Aggregation Inhibitor RI-AG03 Open
Given the pathological role of hyperphosphorylated Tau aggregation in Alzheimer’s disease (AD) our laboratory previously developed the novel Tau aggregation inhibitor peptide, RI-AG03. As Tau aggregates accumulate intracellularly, it is es…
View article: Supplementary Table 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Supplementary Table 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Open
PDF file - 43K, Summary of catalytically active human ADAM family members tested as candidates for copper-enhanced shedding activity
View article: Data from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Data from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Open
A disintegrin and metalloproteinases (ADAMs) and matrix metalloproteinases (MMPs) are zinc metalloproteinases (ZMPs) that catalyze the “ectodomain shedding” of a range of cell surface proteins including signaling and adhesion molecules. Th…
View article: Supplementary Figure 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Supplementary Figure 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Open
PDF file - 101K, Copper-mediated Jagged1 shedding is accompanied by reciprocal decreases in cell-associated holoprotein only at higher, physiologically irrelevant, metal concentrations
View article: Supplementary Figure 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Supplementary Figure 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Open
PDF file - 101K, Copper-mediated Jagged1 shedding is accompanied by reciprocal decreases in cell-associated holoprotein only at higher, physiologically irrelevant, metal concentrations
View article: Supplementary Methods from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Supplementary Methods from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Open
PDF file - 42K
View article: Supplementary Methods from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Supplementary Methods from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Open
PDF file - 42K
View article: Data from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Data from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Open
A disintegrin and metalloproteinases (ADAMs) and matrix metalloproteinases (MMPs) are zinc metalloproteinases (ZMPs) that catalyze the “ectodomain shedding” of a range of cell surface proteins including signaling and adhesion molecules. Th…
View article: Supplementary Figure 2 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Supplementary Figure 2 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Open
PDF file - 87K, The Jagged1 ectodomain generated in the presence of copper is smaller than constitutively-generated sJag
View article: Supplementary Figure 2 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Supplementary Figure 2 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Open
PDF file - 87K, The Jagged1 ectodomain generated in the presence of copper is smaller than constitutively-generated sJag
View article: Supplementary Table 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Supplementary Table 1 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Open
PDF file - 43K, Summary of catalytically active human ADAM family members tested as candidates for copper-enhanced shedding activity
View article: The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein
The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein Open
The amyloid cascade hypothesis proposes that excessive accumulation of amyloid beta-peptides is the initiating event in Alzheimer’s disease. These neurotoxic peptides are generated from the amyloid precursor protein via sequential cleavage…
View article: The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein
The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein Open
The amyloid cascade hypothesis proposes that excessive accumulation of amyloid beta-peptides is the initiating event in Alzheimer’s disease. These neurotoxic peptides are generated from the amyloid precursor protein via sequential cleavage…
View article: Osteonectin as a screening marker for pancreatic cancer: A prospective study
Osteonectin as a screening marker for pancreatic cancer: A prospective study Open
Objective Osteonectin plays a central role in various processes during the development of pancreatic adenocarcinoma. This prospective pilot study was performed to determine the feasibility of serum osteonectin as a screening tool for pancr…
View article: Notch Signalling as a Therapeutic Target in Cancer
Notch Signalling as a Therapeutic Target in Cancer Open
Notch signalling is a conserved developmental pathway involved, inter alia , in cell-fate decision, morphogenesis and tissue patterning. Extensive research has linked this pathways with a variety of malignancies, cancer stem cell renewal,…
View article: Pyruvate dehydrogenase kinase inhibition: Reversing the Warburg effect in cancer therapy
Pyruvate dehydrogenase kinase inhibition: Reversing the Warburg effect in cancer therapy Open
The poor efficacy of many cancer chemotherapeutics, which are often non-selective and highly toxic, is attributable to the remarkable heterogeneity and adaptability of cancer cells. The Warburg effect describes the up regulation of glycoly…