Thomas Pelé
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View article: EMT-ciliary signaling in quasi-mesenchymal-stem-like cells drives therapeutic resistance and is a druggable vulnerability in triple-negative breast cancer
EMT-ciliary signaling in quasi-mesenchymal-stem-like cells drives therapeutic resistance and is a druggable vulnerability in triple-negative breast cancer Open
Cancer therapeutic resistance is mediated, in part, by phenotypic heterogeneity and the plasticity of tumor cells, the latter being enabled by epithelial–mesenchymal transition (EMT). However, EMT in human cancer therapeutic response remai…
View article: O-GlcNAcylation levels remain stable regardless of the anaesthesia in healthy rats
O-GlcNAcylation levels remain stable regardless of the anaesthesia in healthy rats Open
View article: Developing a Clinically Relevant Hemorrhagic Shock Model in Rats
Developing a Clinically Relevant Hemorrhagic Shock Model in Rats Open
Over the recent decades, the development of animal models allowed us to better understand various pathologies and identify new treatments. Hemorrhagic shock, i.e., organ failure due to rapid loss of a large volume of blood, is associated w…
View article: <scp>EMT</scp> and primary ciliogenesis: For better or worse in sickness and in health
<span>EMT</span> and primary ciliogenesis: For better or worse in sickness and in health Open
Summary Epithelial‐mesenchymal transition (EMT) and primary ciliogenesis are two cell‐biological programs that are essential for development of multicellular organisms and whose abnormal regulation results in many diseases (i.e., developme…
View article: A Rat Model of Clinically Relevant Extracorporeal Circulation Develops Early Organ Dysfunctions
A Rat Model of Clinically Relevant Extracorporeal Circulation Develops Early Organ Dysfunctions Open
In clinical practice, extracorporeal circulation (ECC) is associated with coagulopathy and inflammation, eventually leading to organ injuries without preventive systemic pharmacological treatment. Relevant models are needed to reproduce th…
View article: An overview of tools to decipher O-GlcNAcylation from historical approaches to new insights
An overview of tools to decipher O-GlcNAcylation from historical approaches to new insights Open
O-GlcNAcylation is a post-translational modification which affects approximately 5000 human proteins. Its involvement has been shown in many if not all biological processes. Variations in O-GlcNAcylation levels can be associated with the d…
View article: O-GLCNACYLOMIC APPROACH REVEALS ATP CITRATE LYASE AS A POTENTIAL TARGET IN SEPSIS IN THE YOUNG RAT
O-GLCNACYLOMIC APPROACH REVEALS ATP CITRATE LYASE AS A POTENTIAL TARGET IN SEPSIS IN THE YOUNG RAT Open
View article: The Endothelial Dysfunction Could Be a Cause of Heart Failure with Preserved Ejection Fraction Development in a Rat Model
The Endothelial Dysfunction Could Be a Cause of Heart Failure with Preserved Ejection Fraction Development in a Rat Model Open
50% of patients with heart failure have a preserved ejection fraction (HFpEF). Numerous studies have investigated the pathophysiological mechanisms of HFpEF and have shown that endothelial dysfunction plays an important role in HFpEF. Yet …
View article: Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats
Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats Open
Renal ischaemia reperfusion (I/R) triggers a cascade of events including oxidative stress, apoptotic body and microparticle (MP) formation as well as an acute inflammatory process that may contribute to organ failure. Macrophages are recru…
View article: An O-GlcNAcylomic Approach Reveals ACLY as a Potential Target in Sepsis in the Young Rat
An O-GlcNAcylomic Approach Reveals ACLY as a Potential Target in Sepsis in the Young Rat Open
Sepsis in the young population, which is particularly at risk, is rarely studied. O-GlcNAcylation is a post-translational modification involved in cell survival, stress response and metabolic regulation. O-GlcNAc stimulation is beneficial …
View article: Étude des effets potentiels du récepteur MerTK sur le développement des lésions liées à une ischémie/reperfusion rénale chez le rat
Étude des effets potentiels du récepteur MerTK sur le développement des lésions liées à une ischémie/reperfusion rénale chez le rat Open
Ischemia reperfusion is characterized by two distinct phases: a cessation then a return of blood supply and may occur in some pathological situations as well as during organ transplantation. This sequence of events can induce cell death, f…