Thomas Préat
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View article: Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila
Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila Open
Metabolic flexibility allows cells to adapt to different fuel sources, which is particularly important for cells with high metabolic demands 1–3 . In contrast, neurons, which are major energy consumers, are considered to rely essentially o…
View article: Embracing the Modern Biochemistry of Brain Metabolism
Embracing the Modern Biochemistry of Brain Metabolism Open
This editorial challenges the long‐held neuron‐centered view of brain metabolism, relying on ample evidence that it is a cooperative, multicellular process. Astrocytes, oligodendrocytes, and other glia play active roles providing lactate, …
View article: In vivo autofluorescence lifetime imaging of the Drosophila brain captures metabolic shifts associated with memory formation
In vivo autofluorescence lifetime imaging of the Drosophila brain captures metabolic shifts associated with memory formation Open
Neuronal energy regulation is increasingly recognized as a critical factor underlying brain functions and their pathological alterations, yet the metabolic dynamics that accompany cognitive processes remain poorly understood. As a label-fr…
View article: In vivo autofluorescence lifetime imaging of the Drosophila brain captures metabolic shifts associated with memory formation
In vivo autofluorescence lifetime imaging of the Drosophila brain captures metabolic shifts associated with memory formation Open
Neuronal energy regulation is increasingly recognized as a critical factor underlying brain functions and their pathological alterations, yet the metabolic dynamics that accompany cognitive processes remain poorly understood. As a label-fr…
View article: In vivo autofluorescence lifetime imaging of spatial metabolic heterogeneities and learning-induced changes in the <i>Drosophila</i> mushroom body
In vivo autofluorescence lifetime imaging of spatial metabolic heterogeneities and learning-induced changes in the <i>Drosophila</i> mushroom body Open
Neuronal energy regulation is increasingly recognized as a critical factor underlying brain functions and their pathological alterations, yet the metabolic dynamics that accompany cognitive processes remain poorly understood. As a label-fr…
View article: Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling
Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling Open
An essential role of glial cells is to comply with the large and fluctuating energy needs of neurons. Metabolic adaptation is integral to the acute stress response, suggesting that glial cells could be major, yet overlooked, targets of str…
View article: PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation
PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation Open
Relevance-based selectivity and high energy cost are two distinct features of long-term memory (LTM) formation that warrant its default inhibition. Spaced repetition of learning is a highly conserved cognitive mechanism that can lift this …
View article: PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation
PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation Open
Relevance-based selectivity and high energy cost are two distinct features of long-term memory (LTM) formation that warrant its default inhibition. Spaced repetition of learning is a highly conserved cognitive mechanism that can lift this …
View article: Glial metabolism versatility regulates mushroom body–driven behavioral output in<i>Drosophila</i>
Glial metabolism versatility regulates mushroom body–driven behavioral output in<i>Drosophila</i> Open
Providing metabolic support to neurons is now recognized as a major function of glial cells that is conserved from invertebrates to vertebrates. However, research in this field has focused for more than two decades on the relevance of lact…
View article: Spaced training activates Miro/Milton-dependent mitochondrial dynamics in neuronal axons to sustain long-term memory
Spaced training activates Miro/Milton-dependent mitochondrial dynamics in neuronal axons to sustain long-term memory Open
Neurons have differential and fluctuating energy needs across distinct cellular compartments, shaped by brain electrochemical activity associated with cognition. In vitro studies show that mitochondria transport from soma to axons is key t…
View article: Mitochondrial Ca<sup>2+</sup>efflux controls neuronal metabolism and long-term memory across species
Mitochondrial Ca<sup>2+</sup>efflux controls neuronal metabolism and long-term memory across species Open
While impairing neuronal metabolism limits brain performance, it remains poorly understood whether enhancing metabolism in neurons, in contrast, could boost brain function. We find that reducing the expression of the mitochondrial H + /Ca …
View article: PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation
PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation Open
Relevance-based selectivity and high energy cost are two distinct features of long-term memory (LTM) formation that warrant its default inhibition. Spaced repetition of learning is a highly conserved cognitive mechanism that can lift this …
View article: PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation
PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation Open
Relevance-based selectivity and high energy cost are two distinct features of long-term memory (LTM) formation that warrant its default inhibition. Spaced repetition of learning is a highly conserved cognitive mechanism that can lift this …
View article: PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation
PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation Open
Relevance-based selectivity and high energy cost are two distinct features of long-term memory (LTM) formation that warrant its default inhibition. Spaced repetition of learning is a highly conserved cognitive mechanism that can lift this …
View article: Non-autonomous Vnd acts with autonomous Appl during mushroom body axon growth in <i>Drosophila</i>
Non-autonomous Vnd acts with autonomous Appl during mushroom body axon growth in <i>Drosophila</i> Open
The Amyloid Precursor Protein (APP) is associated with Alzheimer’s disease. Appl is the single Drosophila APP ortholog and is expressed in all neurons throughout development. Appl was previously shown to cell-autonomously modulate axon out…
View article: Long-term memory formation depends on an astrocyte-to-neuron H<sub>2</sub>O<sub>2</sub>signaling
Long-term memory formation depends on an astrocyte-to-neuron H<sub>2</sub>O<sub>2</sub>signaling Open
Astrocytes interact with neurons during cognitive processes 1 . In particular, astrocytes help neurons to fight oxidative stress 2 , a needed function since active neurons are prone to reactive oxygen species (ROS) damage due to their high…
View article: Developmental transcriptional control of mitochondrial homeostasis is required for activity-dependent synaptic connectivity
Developmental transcriptional control of mitochondrial homeostasis is required for activity-dependent synaptic connectivity Open
During neuronal circuit formation, local control of axonal organelles ensures proper synaptic connectivity. Whether this process is genetically encoded is unclear and if so, its developmental regulatory mechanisms remain to be identified. …
View article: The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance
The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance Open
FTSJ1 is a conserved human 2′-O-methyltransferase (Nm-MTase) that modifies several tRNAs at position 32 and the wobble position 34 in the anticodon loop. Its loss of function has been linked to X-linked intellectual disability (XLID), and …
View article: A New Behavioral Paradigm for Visual Classical Conditioning in <em>Drosophila</em>
A New Behavioral Paradigm for Visual Classical Conditioning in <em>Drosophila</em> Open
Visual learning in animals is a remarkable cognitive ability that plays a crucial role in their survival and adaptation. Therefore, the ability to learn is highly conserved among animals. Despite lacking a centralized nervous system like v…
View article: Numerical discrimination in <i>Drosophila melanogaster</i>
Numerical discrimination in <i>Drosophila melanogaster</i> Open
Sensitivity to numbers is a crucial and evolutionarily conserved cognitive ability. The lack of experimental models amenable to systematic genetic and neural manipulation has precluded discovering circuits required for numerical cognition.…
View article: Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation Open
During starvation, mammalian brains can adapt their metabolism, switching from glucose to alternative peripheral fuel sources. In the Drosophila starved brain, memory formation is subject to adaptative plasticity, but whether this adaptive…