Thomas Quail
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View article: Cryo-EM reveals open and closed Asgard chromatin assemblies
Cryo-EM reveals open and closed Asgard chromatin assemblies Open
Summary Asgards are the closest archaeal relatives of eukaryotes, representing an important step in chromatin evolution. However, their chromatin organization has remained enigmatic until now. In this study, we present the first structures…
View article: Nuclear partitioning by surface condensation on metaphase chromatids
Nuclear partitioning by surface condensation on metaphase chromatids Open
Protein partitioning between the nucleus and the cytoplasm is a defining feature of eukaryotic cells, and it is thought to be primarily regulated by transport across the nuclear envelope. However, during early vertebrate development, ensur…
View article: PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends
PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends Open
DNA double-strand breaks (DSBs) are repaired at DSB sites. How DSB sites assemble and how broken DNA is prevented from separating is not understood. Here we uncover that the synapsis of broken DNA is mediated by the DSB sensor protein poly…
View article: Force generation by protein-DNA co-condensation
Force generation by protein-DNA co-condensation Open
Interactions between liquids and surfaces generate forces 1,2 that are crucial for many processes in biology, physics, and engineering, including the motion of insects on the surface of water 3 , modulation of the material properties of sp…
View article: Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner
Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner Open
Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been proposed as a mechanism to organize chromatin in interphase and metaphase. However, the requirements for chromatin organization in these cell cycle phases are…
View article: Author response: Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner
Author response: Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Loop extrusion by structural maintenance o…
Cohesin and condensin extrude loops in a cell-cycle dependent manner Open
Chromatin undergoes a dramatic reorganization during the cell cycle 1–3 . In interphase, chromatin is organized into compartments and topological-associating domains (TADs) that are cell-type specific 4–7 , whereas in metaphase, chromosome…