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View article: Differential impact of high-salt levels in vitro and in vivo on macrophage core functions
Differential impact of high-salt levels in vitro and in vivo on macrophage core functions Open
View article: Differential impact of high-salt levels in vitro and in vivo on macrophage core functions
Differential impact of high-salt levels in vitro and in vivo on macrophage core functions Open
The consumption of processed food is on the rise leading to huge intake of excess dietary salt, which strongly correlates with development of hypertension, often leading to cardiovascular diseases such as stroke and heart attack, as well a…
View article: Table S7 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Table S7 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Table S7. Hallmark gene sets up in ACT-treated relapse (R) HCmel3 melanomas versus early during treatment (EDT) HCmel3 melanomas (GSEA results).
View article: Table S3 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Table S3 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Table S3. Gene sets correlating with NT5E (CD73) expression in MITFhigh melanoma cell lines from the Broad melanoma cell line panel (GSEA results).
View article: Table S5 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Table S5 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Table S5. Hallmark gene sets up in amelanotic BrafV600ExCdk4R24C melanomas versus pigmented BrafV600ExCdk4R24C melanomas (GSEA results).
View article: Supplementary Figure 1 to 7 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Supplementary Figure 1 to 7 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Figure S1. Validation of anti-CD73 antibody used for IHC and analysis of cutaneous melanoma metastases. Supplemental Figure S2. Next-generation sequencing based analysis of bisulfite conversion to assess CpG island methylation…
View article: Table S5 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Table S5 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Table S5. Hallmark gene sets up in amelanotic BrafV600ExCdk4R24C melanomas versus pigmented BrafV600ExCdk4R24C melanomas (GSEA results).
View article: Table S7 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Table S7 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Table S7. Hallmark gene sets up in ACT-treated relapse (R) HCmel3 melanomas versus early during treatment (EDT) HCmel3 melanomas (GSEA results).
View article: Supplementary Figure 1 to 7 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Supplementary Figure 1 to 7 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Figure S1. Validation of anti-CD73 antibody used for IHC and analysis of cutaneous melanoma metastases. Supplemental Figure S2. Next-generation sequencing based analysis of bisulfite conversion to assess CpG island methylation…
View article: Legends to Suppl. Figures from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Legends to Suppl. Figures from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Legends to Supplemental Figures 1 to 7
View article: Data from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Data from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Evolution of tumor cell phenotypes promotes heterogeneity and therapy resistance. Here we found that induction of CD73, the enzyme that generates immunosuppressive adenosine, is linked to melanoma phenotype switching. Activating MAPK mutat…
View article: Data from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Data from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Evolution of tumor cell phenotypes promotes heterogeneity and therapy resistance. Here we found that induction of CD73, the enzyme that generates immunosuppressive adenosine, is linked to melanoma phenotype switching. Activating MAPK mutat…
View article: Legends to Suppl. Figures from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Legends to Suppl. Figures from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Legends to Supplemental Figures 1 to 7
View article: Tables S1, S2, S4, S8, S9 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Tables S1, S2, S4, S8, S9 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Table S1. DNA oligos used in this study Supplemental Table S2. Characteristics of patients with primary melanomas and cutaneous melanoma metastasis (Bonn cohorts). Supplemental Table S4. List of transcription factors binding i…
View article: Table S3 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Table S3 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Table S3. Gene sets correlating with NT5E (CD73) expression in MITFhigh melanoma cell lines from the Broad melanoma cell line panel (GSEA results).
View article: Supplementary Methods from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Supplementary Methods from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
This file contains updated supplemental methods
View article: Tables S1, S2, S4, S8, S9 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Tables S1, S2, S4, S8, S9 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Table S1. DNA oligos used in this study Supplemental Table S2. Characteristics of patients with primary melanomas and cutaneous melanoma metastasis (Bonn cohorts). Supplemental Table S4. List of transcription factors binding i…
View article: Table S6 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Table S6 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Table S6. Hallmark gene sets up in ACT-treated HCmel3 melanomas (EDT, early during treatment) versus non-treated (NT) control HCmel3 melanomas (GSEA results).
View article: Table S6 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Table S6 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
Supplemental Table S6. Hallmark gene sets up in ACT-treated HCmel3 melanomas (EDT, early during treatment) versus non-treated (NT) control HCmel3 melanomas (GSEA results).
View article: Supplementary Methods from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Supplementary Methods from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy Open
This file contains updated supplemental methods
View article: Praxisbeitrag: Multimethodenansatz in der Evaluation am Beispiel der Dialogveranstaltung „Mensch Wissenschaft!“
Praxisbeitrag: Multimethodenansatz in der Evaluation am Beispiel der Dialogveranstaltung „Mensch Wissenschaft!“ Open
Zusammenfassung Mit „Mensch Wissenschaft!“ hat die Robert Bosch Stiftung in einem mehrstufigen und durch eine Evaluation begleiteten Verfahren ein dialogisches und partizipatives Angebot der Wissenschaftskommunikation entwickelt. Dabei han…
View article: Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells
Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells Open
Centrosomes play a crucial role during immune cell interactions and initiation of the immune response. In proliferating cells, centrosome numbers are tightly controlled and generally limited to one in G1 and two prior to mitosis. Defects i…
View article: A Stable Chemokine Gradient Controls Directional Persistence of Migrating Dendritic Cells
A Stable Chemokine Gradient Controls Directional Persistence of Migrating Dendritic Cells Open
Navigation of dendritic cells (DCs) from the site of infection to lymphoid organs is guided by concentration gradients of CCR7 ligands. How cells interpret chemokine gradients and how they couple directional sensing to polarization and per…
View article: GPR183 Targets Lung-Resident CD301b <sup>+</sup> Conventional Dendritic Cells Type 2 to a Subtissular TSLP – TSLP Receptor Mediated Survival Niche Within the Adventitial Cuff
GPR183 Targets Lung-Resident CD301b <sup>+</sup> Conventional Dendritic Cells Type 2 to a Subtissular TSLP – TSLP Receptor Mediated Survival Niche Within the Adventitial Cuff Open
View article: NCX1 represents an ionic Na+ sensing mechanism in macrophages
NCX1 represents an ionic Na+ sensing mechanism in macrophages Open
Inflammation and infection can trigger local tissue Na(+)accumulation. This Na+-rich environment boosts proinflammatory activation of monocyte/macrophage-like cells (M phi s) and their antimicrobial activity. Enhanced Na+-driven M phi func…
View article: Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2
Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2 Open
Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their physiological counterparts, ontogeny, transcriptional regulation, and heterogene…
View article: Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression
Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression Open
Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-cell infiltration and the number of neoantigens caused by tumor-specific mutations are correlated to favorable responses in cancers with a high mu…
View article: Hyperosmolarity impedes the cross-priming competence of dendritic cells in a TRIF-dependent manner
Hyperosmolarity impedes the cross-priming competence of dendritic cells in a TRIF-dependent manner Open
View article: Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion
Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion Open
Leukocyte trafficking is crucial to facilitate efficient immune responses. Here, we report that the large GTPase dynamin2, which is generally considered to have a key role in endocytosis and membrane remodeling, is an essential regulator o…
View article: CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming
CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming Open