Thomas Reske
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View article: Determination of polyethylene glycol content in binary polymer blends by size exclusion chromatography with regard to polydispersity
Determination of polyethylene glycol content in binary polymer blends by size exclusion chromatography with regard to polydispersity Open
Using Size exclusion chromatography (SEC), the molar masses Mn and Mw in a binary polymer mixture with polyethylene glycol are to be determined in order to find a mathematical relationship at different PEG contents. Based on this, a quanti…
View article: In Vitro Release Dynamics of Atorvastatin-Loaded Alginate Particles for Enhanced Periodontal Treatment
In Vitro Release Dynamics of Atorvastatin-Loaded Alginate Particles for Enhanced Periodontal Treatment Open
Periodontitis is a chronic inflammatory condition of the periodontium, which often leads to tooth loss. Recently, statins have emerged as potent anti-inflammatory agents with pleiotropic effects that can potentially outperform conventional…
View article: Effect of Steroids on the Progression of Alzheimer's Dementia: A Retrospective Chart Review
Effect of Steroids on the Progression of Alzheimer's Dementia: A Retrospective Chart Review Open
Objectives Alzheimer's disease (AD) is a prevalent age‐related neurodegenerative disease that affects millions of individuals in the United States. Neuroinflammation is a driver of the neurodegenerative changes that characterize AD, prompt…
View article: In vitro biostability testing of stent cover materials
In vitro biostability testing of stent cover materials Open
Cast polyurethane films made of an aliphatic polycarbonate-based thermoplastic polyurethane (Carbothane PC) and poly(ether urethane) (Pellethane) were manufactured and their biostability under a static strain rate was investigated in vitro…
View article: Manufacturing of porous polymer films as a basis for the novel cardiovascular implant devices
Manufacturing of porous polymer films as a basis for the novel cardiovascular implant devices Open
For applications in the cardiovascular field, the production of tailored biomaterials such as those required for insulations or patches is a key technology. In this work we were able to manufacture thermoplastic silicone polycarbonate elas…
View article: Trends in Medicare utilization and reimbursement for hematology/oncology procedures from 2012 to 2023: A geriatric oncology perspective
Trends in Medicare utilization and reimbursement for hematology/oncology procedures from 2012 to 2023: A geriatric oncology perspective Open
Objectives Given the scarcity of data exploring reimbursement trends in the field of hematology/oncology, we sought to characterize these trends for common procedures in this field from 2012 to 2023. Methods Using the Centers for Medicare …
View article: Post-modification of PLLA nanofiber nonwovens by various solvent treatments
Post-modification of PLLA nanofiber nonwovens by various solvent treatments Open
Degradable polymeric Biomaterials, such as polylactic acid, are widely used in medical field as bioresorbable implant coatings. More recently, stent covers, implantable tubes or wound dressings made from electrospun nanofibers have been de…
View article: Pirfenidone release from ophthalmic implants – perspectives for a drug-eluting microstent for glaucoma therapy
Pirfenidone release from ophthalmic implants – perspectives for a drug-eluting microstent for glaucoma therapy Open
Elevated intraocular pressure is the main risk factor for glaucoma and its adjustment to physiological levels can prevent progression of the disease. If conventional drop-based glaucoma therapy fails, surgical interventions such as trabecu…
View article: Biological test methods for stents: cellular responses to microstructured biomaterials
Biological test methods for stents: cellular responses to microstructured biomaterials Open
One of the greatest challenges in the development of novel implants is to find materials that optimally interact with the tissue and support the function of the implant over a long period of time. Especially considering the fact that bioma…
View article: Comparison of accelerated and enzyme-associated real-time degradation of HMW PLLA and HMW P3HB films
Comparison of accelerated and enzyme-associated real-time degradation of HMW PLLA and HMW P3HB films Open
Designing laboratory-scale degradation experiments for polymer-based biomaterials is crucial for the development of safe and functional implants, in particular regarding high molecular weight polyesters. Within this work, we compared accel…
View article: Polymer selection for Eustachian tube stent application based on mechanical, thermal and degradation behavior
Polymer selection for Eustachian tube stent application based on mechanical, thermal and degradation behavior Open
The novel concept of stenting the Eustachian tube was established to provide an effective and safe therapy of Eustachian tube dysfunction. Biodegradable polymer stents are being developed to restore impaired tube function. As the supportin…
View article: Drug-eluting coating of extruded polymeric tubular microstructures
Drug-eluting coating of extruded polymeric tubular microstructures Open
Extrusion is a common manufacturing process for semi-finished polymer products in various biomedical applications. Extrusion enables processing of a wide range of biomaterials, as well as different cross-sectional geometries. Furthermore, …
View article: Quantitative evaluation of cell morphology and material interactions on opaque biomaterials
Quantitative evaluation of cell morphology and material interactions on opaque biomaterials Open
One of the key aspects in the development of novel implants is to find suitable materials and understand the mechanisms that occur when a material is exposed to the tissues of the human body. These mechanisms are commonly referred to as th…
View article: Antibiotic-loaded nonwovens as protection against implant-associated infection
Antibiotic-loaded nonwovens as protection against implant-associated infection Open
Implant-associated infections still must be considered as a major risk factor and represent a significant threat to the well-being of patients. The detection of such complications is often late, making therapy at this stage difficult. Howe…
View article: Non-destructive analysis of drug distribution in nonwovens as drug-delivery systems for biomedical applications
Non-destructive analysis of drug distribution in nonwovens as drug-delivery systems for biomedical applications Open
Analysis of the active ingredient distribution of medical devices is typically performed using Raman spectroscopy, a method that is fast and inexpensive [1]. In addition, it offers the advantage of non-destructive analysis without the need…
View article: Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices—A Systematic Study
Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices—A Systematic Study Open
Local drug delivery has become indispensable in biomedical engineering with stents being ideal carrier platforms. While local drug release is superior to systemic administration in many fields, the incorporation of drugs into polymers may …
View article: Accelerated Degradation of polymeric surgical suture materials
Accelerated Degradation of polymeric surgical suture materials Open
The degradable polymer Polydioxanone (PDO) is used for medical implants since 1981. Manufacturers state a degradation timeframe of <180 days or an absorption duration of 182-238 days [1, 2]. Aim of this study was to find in vitro-condition…
View article: DLP 3D printing of Dexamethasoneincorporated PEGDA-based photopolymers: compressive properties and drug release
DLP 3D printing of Dexamethasoneincorporated PEGDA-based photopolymers: compressive properties and drug release Open
Photopolymerizing, high-resolution 3D printing methods such as Stereolithography (SLA) or Digital Light Processing (DLP) are very promising for the manufacturing of drug-incorporated, patient specific implants. However, a drug-load may be …
View article: Physico chemical and phase separation characterization of high molecular PLLA blended with low molecular PCL obtained from solvent cast processes
Physico chemical and phase separation characterization of high molecular PLLA blended with low molecular PCL obtained from solvent cast processes Open
Blends of PLLA and PCL yielded by solvent casting usually exhibit phase separation and crystallization behavior which have a strong impact on their suitability for certain biomedical applications such as degradable coatings or drug carrier…
View article: Adaptable Superfibers as Implant Material
Adaptable Superfibers as Implant Material Open
Electrospun fiber nonwoven materials of different polymer classes provide promising perspectives in almost all fields of application, including medical science. In this paper we present the fiber generation of selected biostable polymers (…
View article: Degradable dual co-electrospun polyester based nonwovens for guided tissue regeneration
Degradable dual co-electrospun polyester based nonwovens for guided tissue regeneration Open
In this study, initial experiments are presented regarding the suitability of polyester based nonwoven composite materials for guided tissue regeneration based on degradation. The in vitro degradation of poly(lactic-coglycolic acid)/polydi…
View article: Safety evaluation of resveratrol as an active compound for drug-eluting cardiovascular implants
Safety evaluation of resveratrol as an active compound for drug-eluting cardiovascular implants Open
Resveratrol is a member of stilbenoids with promising anti-atherosclerotic properties. This hallmark makes it an extremely interesting candidate for local drug delivery to damaged tissue adjacent to the implant in order to reduce implant-r…
View article: Non-destructive analysis of drug content in polymer coatings with Raman spectroscopy
Non-destructive analysis of drug content in polymer coatings with Raman spectroscopy Open
The analysis of device drug content typically is carried out by means of chromatographic methods such as high performance liquid chromatography (HPLC) or liquid chromatography-mass spectrometry (LCMS). These approved methods are particular…
View article: Development of an antifibrotic drug-eluting coating for a minimally invasive implantable glaucoma microstent
Development of an antifibrotic drug-eluting coating for a minimally invasive implantable glaucoma microstent Open
Primary open angle glaucoma represents an eye disease that usually is associated with an increased intraocular pressure (IOP). Implants for micro-invasive glaucoma surgery (MIGS) are gaining importance as a promising option for IOP lowerin…
View article: Actinomycin D for fibrosis management in ophthalmic implant surgery
Actinomycin D for fibrosis management in ophthalmic implant surgery Open
Implants that feature a drug delivery system loaded with antifibrotic active drugs provide a promising approach to address postoperative complications caused by fibrosis. This study is intended to clarify whether Actinomycin D has an impac…
View article: In vitro study of sirolimus release from nonwoven PLLA matrices
In vitro study of sirolimus release from nonwoven PLLA matrices Open
Sirolimus incorporated nonwoven polymer matrices were fabricated via electrospinning. Release kinetics considering different fiber diameters and layer thicknesses were investigated. In vitro drug release profiles were evaluated by measurin…
View article: Electrospinning for polymeric implants in cardiovascular applications
Electrospinning for polymeric implants in cardiovascular applications Open
Electrospinning is a method for producing fibrous polymer scaffolds that can be applied in drug delivery systems as well as for polymer-based implants. Biodegradable polymers for the purpose of cardiac tissue engineering are often applied …
View article: Automated particle analysis by Raman microscopy – a method development
Automated particle analysis by Raman microscopy – a method development Open
Chemical identification of particles increasingly gains importance concerning regulatory affairs of medical devices. Particle numbers of samples very easily add up to orders larger than 1.000. Therefore an automated particle measurement is…
View article: Development of a biodegradable antifibrotic local drug delivery system for glaucoma microstents
Development of a biodegradable antifibrotic local drug delivery system for glaucoma microstents Open
To prevent implant failure due to fibrosis is a major objective in glaucoma research. The present study investigated the antifibrotic effects of paclitaxel (PTX), caffeic acid phenethyl ester (CAPE), and pirfenidone (PFD) coated microstent…
View article: In vitro chlorhexidine release from alginate based microbeads for periodontal therapy
In vitro chlorhexidine release from alginate based microbeads for periodontal therapy Open
Periodontitis is one of the most common infectious diseases globally that, if untreated, leads to destruction of the tooth supporting tissues and finally results in tooth loss. Evidence shows that standard procedures as mechanical root cle…