Thomas Roetzer-Pejrimovsky

P04.01.A THE DIGITAL BRAIN TUMOUR ATLAS: AN UPDATE INTEGRATING THE 5TH EDITION OF THE WHO CLASSIFICATION OF CNS TUMOURS Open

Thomas Roetzer-Pejrimovsky, Adelheid Wöehrer · 2025

BACKGROUND Digital pathology methods are increasingly applied for enhancing disease classification and prognostic rating in neuro-oncology. The development of robust computational algorithms relies on well-annotated training datasets. The …

P10.25.B STIMULATED RAMAN HISTOLOGY FOR INTRAOPERATIVE DIAGNOSIS OF PEDIATRIC BRAIN TUMORS Open

Jessica Makolli, L. Körner, G Kucinska, Rebecca Mödl, C Vogel , et al. · 2025

BACKGROUND Intraoperative frozen sections are an essential part of neuropathological evaluation during pediatric neurosurgical tumor resections. However, tissue processing and analysis can take up to 45 minutes. Recently, stimulated Raman …

P04.08.A NEAR REAL-TIME INTRAOPERATIVE CLASSIFICATION OF SPINAL TUMORS USING LABEL-FREE STIMULATED RAMAN HISTOLOGY AND ARTIFICIAL INTELLIGENCE Open

David Reinecke, Nina Müller, A Ion-Margineau, Anna-Katharina Meißner, Gina Fürtjes , et al. · 2025

BACKGROUND Accurate intraoperative tissue diagnosis is essential for surgical guidance, preserving neurological function, and selecting appropriate adjuvant therapies in spinal tumor surgery. Current state-of-the-art AI models trained on i…

EP03.02 IMAGING-BASED PREDICTION OF 5-ALA FLUORESCENCE IN GLIOMAS USING PREOPERATIVE 7T MRSI COMPARED TO T1W MRI AND PET Open

Sara Huskić, Philipp Lazen, Cornelius Cadrien, Thomas Roetzer-Pejrimovsky, Barbara Kiesel , et al. · 2025

BACKGROUND Maximizing the extent of safe tumor resection is a critical factor influencing survival outcomes in glioma patients. The use of 5-aminolevulinic acid (5-ALA) fluorescence has proven effective in enhancing resection, particularly…

P04.09.A AI-ENHANCED STIMULATED RAMAN HISTOLOGY FOR NEAR REAL-TIME PRIMARY CNS LYMPHOMA IDENTIFICATION AND DIFFERENTIATION FROM OTHER CNS LESIONS Open

David Reinecke, N. Maarouf, Alastair Smith, Dagmar Alber, John Markert , et al. · 2025

BACKGROUND Distinguishing primary central nervous system lymphoma (PCNSL) from other brain lesions during surgery remains challenging due to overlapping histological features and time constraints. Accurate differentiation is critically imp…

P04.07.A AI-BASED NUCLEAR MORPHOMETRY REVEALS DISTINCT MORPHOLOGICAL PATTERNS BETWEEN IDH-MUTANT, IDH-WILDTYPE, AND NON-TUMOROUS CELLS IN STIMULATED RAMAN HISTOLOGY Open

David Reinecke, Nicholas K. Goff, John Markert, N. Maarouf, Alexander Smith , et al. · 2025

BACKGROUND Isocitrate dehydrogenase (IDH) mutation status significantly influences diffuse glioma classification. While molecular testing remains the gold standard, we investigated whether cell nuclear morphology in virtual H&E-like images…

Uncertainty-aware ensemble of foundation models differentiates glioblastoma from its mimics Open

Junhan Zhao, Shih‐Yen Lin, Raphaël Attias, Liza Mathews, Christian Engel , et al. · 2025

The Presence of Neutrophil Extracellular Traps (NETs) in Brain Tumor Vessels Is Linked to Platelet Aggregates and Podoplanin in the Tumor Microenvironment Open

Pegah Mir Seyed Nazari, Öykü Özer, Thomas Roetzer-Pejrimovsky, Maximilian J. Mair, Julia Riedl , et al. · 2025

Background: Multiple mechanisms might lead to cancer-related hypercoagulability. In brain tumors, podoplanin, via its ability to activate platelets, seems to play a crucial role in developing venous thromboembolism (VTE). Different stimuli…

High-Resolution Mapping of Tumor and Peritumoral Glutamate and Glutamine in Gliomas Using 7-T MRSI Open

Gilbert Hangel, Philipp Lazen, Cornelius Cadrien, Stefanie Chambers, Julia Furtner , et al. · 2025

The 7-T MR spectroscopic imaging revealed increased glutamate and glutamine metabolic ratios within the peritumoral region compared with normal-appearing white matter in patients with glioma distinct from intratumoral changes, suggesting i…

Rapid Molecular Classification of Brain Tumours Through DNA Methylation Analysis with Nanopore Sequencing Open

Elena Bondareva, Sylvain Moser, Thomas Roetzer-Pejrimovsky, Romana Höftberger, Christine Haberler , et al. · 2025

pathoDISCO-HE: Towards light sheet microscopy enabled volumetric histopathology of human gliomas Open

James Oakes-Klein, Saiedeh Saghafi, Thomas Roetzer-Pejrimovsky, Christoph Fuchssteiner, Katherina Grin , et al. · 2025

Histopathological assessment of human tumours relies heavily upon traditional slide-based techniques such as H&E staining and immunohistochemistry. Whilst providing excellent resolution, traditional histological techniques require destruct…

Paired Use of Stimulated Raman Histology and Two Photon Fluorescence Microscopy in Meningioma Surgery Open

Lisa Koerner, Thomas Roetzer-Pejrimovsky, Barbara Kiesel, Mario Mischkulnig, Matthias Millesi , et al. · 2025

Intraoperative Resection Margin Control in Brain Metastasis Surgery Using Rapid Stimulated Raman Histology and Artificial Intelligence-based Analysisintraint Open

Lili Leyer, Georg Widhalm, Anna-Katharina Meißner, Nina Müller, Thomas Roetzer-Pejrimovsky , et al. · 2025

Analysis of the Porphyrin Peak Shift and Fluorescence Lifetime in Gliomas with Different Tumor Grades, Intratumoral Regions, and Visible Fluorescence Status Open

Lisa Körner, David Reichert, Marco Andreana, Angelika Unterhuber, Mikael T. Erkkilä , et al. · 2024

Background: 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence shows high sensitivity in detecting the tumor core of high-grade gliomas (HGG) but poor sensitivity for tissue of low-grade gliomas (LGG) and the margi…

Foundation models for fast, label-free detection of glioma infiltration Open

Akhil Kondepudi, Melike Pekmezci, Xinhai Hou, Katie Scotford, Cheng Jiang , et al. · 2024

A critical challenge in glioma treatment is detecting tumour infiltration during surgery to achieve safe maximal resection^1-3. Unfortunately, safely resectable residual tumour is found in the majority of patients with glioma aft…

Imaging of increased peritumoral glutamate and glutamine in gliomas using 7T MRSI Open

Gilbert Hangel, Philipp Lazen, Cornelius Cadrien, Stefanie Chambers, Julia Furtner , et al. · 2024

Objectives Diffuse gliomas, due to their infiltrative properties, still lack effective treatment options. Recent research indicates that infiltration, malignancy, and symptoms such as epilepsy are related to synaptic connections between in…

Glioblastoma in the real-world setting: patterns of care and outcome in the Austrian population Open

Andreas Hainfellner, Martin Borkovec, Lukas Seebrecht, Magdalena Neuhauser, Thomas Roetzer-Pejrimovsky , et al. · 2024

Purpose We present results of a retrospective population-based investigation of patterns of care and outcome of glioblastoma patients in Austria. Patients and methods In this nation-wide cooperative project, all Austrian glioblastoma patie…

Fast intraoperative detection of primary CNS lymphoma and differentiation from common CNS tumors using stimulated Raman histology and deep learning Open

David Reinecke, Nader Maroouf, Andrew Smith, Daniel Alexander Alber, John Markert , et al. · 2024

Background Accurate intraoperative diagnosis is crucial for differentiating between primary CNS lymphoma (PCNSL) and other CNS entities, guiding surgical decision-making, but represents significant challenges due to overlapping histomorpho…

A Systems Perspective on the Interactions Between Urban Green Infrastructure and the Built Environment Open

Roland Reitberger, Nayanesh Pattnaik, Leila Parhizgar, Christopher S. Trost, Hadi Yazdi , et al. · 2024

This research addresses the intricate dynamics between urban green infrastructure (UGI) and the built environment, focusing on the effects of urban heat islands, building energy demand, and human health. Following the idea of the Socio-Eco…

Is location more determining than WHO grade for long-term clinical outcome in patients with meningioma in the first two decades of life? Open

Dorian Hirschmann, Danial Nasiri, Christian Joachim Entenmann, Christine Haberler, Thomas Roetzer-Pejrimovsky , et al. · 2024

7 Tesla magnetic resonance spectroscopic imaging predicting IDH status and glioma grading Open

Cornelius Cadrien, Sukrit Sharma, Philipp Lazen, Roxane Licandro, Julia Furtner , et al. · 2024

Introduction With the application of high-resolution 3D 7 Tesla Magnetic Resonance Spectroscopy Imaging (MRSI) in high-grade gliomas, we previously identified intratumoral metabolic heterogeneities. In this study, we evaluated the potentia…

Visual foundation models for fast, label-free detection of diffuse glioma infiltration Open

Todd Hollon, Akhil Kondepudi, Melike Pekmezci, Xinhai Hou, Katie Scotford , et al. · 2024

A critical challenge in diffuse glioma treatment is detecting tumor infiltration during surgery to achieve safe maximal resection[1-3]. Unfortunately, safely resectable residual tumor is found in the majority of glioma patients after surge…

A Comparison of 7 Tesla MR Spectroscopic Imaging and 3 Tesla MR Fingerprinting for Tumor Localization in Glioma Patients Open

Philipp Lazen, Pedro Lima Cardoso, Sukrit Sharma, Cornelius Cadrien, Thomas Roetzer-Pejrimovsky , et al. · 2024

This paper investigated the correlation between magnetic resonance spectroscopic imaging (MRSI) and magnetic resonance fingerprinting (MRF) in glioma patients by comparing neuro-oncological markers obtained from MRSI to T1/T2 maps from MRF…

Preliminary insights into the correlations between 5-ALA fluorescence and 7T MRSI in gliomas Open

Sara Huskić, DI Philipp Lazen, Cornelius Cadrien, MMsc Sagar Acharya, Thomas Roetzer-Pejrimovsky , et al. · 2024

Intraoperative Precision Sampling of Tumor Microenvironments based on 7T MRSI: A pipeline development Open

Sagar Acharya, Cornelius Cadrien, Sara Huskić, Philipp Lazen, Claus Brenner , et al. · 2024

Deep learning links localized digital pathology phenotypes with transcriptional subtype and patient outcome in glioblastoma Open

Thomas Roetzer-Pejrimovsky, Karl‐Heinz Nenning, Barbara Kiesel, Johanna Klughammer, Martin Rajchl , et al. · 2024

Background Deep learning has revolutionized medical image analysis in cancer pathology, where it had a substantial clinical impact by supporting the diagnosis and prognostic rating of cancer. Among the first available digital resources in …

GBMatch_CNN - additional data Open

Thomas Roetzer-Pejrimovsky · 2023

In this repository, you can find additional data for our "GBMatch_CNN" project. Please refer to the github-page for further information: https://github.com/tovaroe/GBMatch_CNN Included are two datasets: 1. GBMatch_included_tiles.7z include…

GBMatch_CNN - additional data Open

Thomas Roetzer-Pejrimovsky · 2023

In this repository, you can find additional data for our "GBMatch_CNN" project. Please refer to the github-page for further information: https://github.com/tovaroe/GBMatch_CNN Included are two datasets: 1. GBMatch_included_tiles.7z include…

Mapping high-grade glioma immune infiltration to 5-ALA fluorescence levels: TCGA data computation, classical histology, and digital image analysis Open

Alexandra Lang, Raphael L Jeron, Bastian Lontzek, Barbara Kiesel, Mario Mischkulnig , et al. · 2023

Purpose Resection of high-grade gliomas has been considerably improved by 5-aminolevulinic acid (5-ALA). However, not all neurobiological properties of 5-ALA are fully understood. Specifically, potential differences in immune infiltration …

A comparison of 7 Tesla MR spectroscopic imaging and 3 Tesla MR fingerprinting for tumor localization in glioma patients Open

Philipp Lazen, Pedro Lima Cardoso, Sukrit Sharma, Cornelius Cadrien, Thomas Roetzer-Pejrimovsky , et al. · 2023

This paper investigates the correlation between magnetic resonance spectroscopic imaging (MRSI) and magnetic resonance fingerprinting (MRF) in glioma patients by comparing neuro-oncological markers obtained from MRSI to T1/T2 maps from MRF…

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