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View article: The implementation challenge of computerised clinical decision support systems for the detection of disease in primary care: systematic review and recommendations
The implementation challenge of computerised clinical decision support systems for the detection of disease in primary care: systematic review and recommendations Open
The range and scale of the barriers and complexity of recommendations highlight implementation challenges for CDSS in primary care. Although recommendations can be used to improve implementation, our findings emphasise the need to carefull…
View article: Clinical referral to the NHS following multi-cancer early detection test results from the NHS-Galleri trial
Clinical referral to the NHS following multi-cancer early detection test results from the NHS-Galleri trial Open
Introduction The large, randomised, controlled NHS-Galleri trial (NCT05611632) is assessing the clinical utility of a multi-cancer early detection (MCED) test for asymptomatic cancer screening in England. We describe how we enabled the eff…
View article: Characterising the volume and variation of multiple urgent suspected cancer referrals in England, April 2013–March 2018: a national cohort study
Characterising the volume and variation of multiple urgent suspected cancer referrals in England, April 2013–March 2018: a national cohort study Open
Objectives To establish a methodology to categorise urgent suspected cancer (USC) referrals in England and use these categories to understand individual patient referral patterns by demographic characteristics, financial year and referral …
View article: Primary care assessment of transient loss of consciousness in adults
Primary care assessment of transient loss of consciousness in adults Open
View article: Cardiovascular disease — risk assessment and reduction: NICE 2023 update for GPs
Cardiovascular disease — risk assessment and reduction: NICE 2023 update for GPs Open
View article: A multi-cancer early detection (MCED) test: clinical update for GPs
A multi-cancer early detection (MCED) test: clinical update for GPs Open
View article: Advice after urgent suspected cancer referral when cancer is not found in England: Survey of patients’ preferences and perceived acceptability
Advice after urgent suspected cancer referral when cancer is not found in England: Survey of patients’ preferences and perceived acceptability Open
There is a potential unmet need for advice after USC referral when no cancer is found. Equitable intervention design should focus on increasing acceptability for people from ethnic minority groups and those with lower levels of education.
View article: Text-message reminders to increase participation in colorectal cancer screening
Text-message reminders to increase participation in colorectal cancer screening Open
View article: Transforming post pandemic cancer services
Transforming post pandemic cancer services Open
View article: Future cancer risk after urgent suspected cancer referral in England when cancer is not found: a national cohort study
Future cancer risk after urgent suspected cancer referral in England when cancer is not found: a national cohort study Open
View article: Uterine adenomyosis: an update for GPs
Uterine adenomyosis: an update for GPs Open
View article: Cancer and Primary Care; Shifting the Narrative
Cancer and Primary Care; Shifting the Narrative Open
In this issue we lead with a cancer theme.For over 10 years some of the BJGP 's most impactful papers have focused on this area, including developing the evidence base for symptom-based approaches to cancer diagnosis.Many studies have used…
View article: Guidance on faecal immunochemical testing (FIT) to help diagnose colorectal cancer among symptomatic patients in primary care
Guidance on faecal immunochemical testing (FIT) to help diagnose colorectal cancer among symptomatic patients in primary care Open
View article: Should we? Could we? Feasibility of interventions to support prevention or early diagnosis of future cancer following urgent referral: A qualitative study
Should we? Could we? Feasibility of interventions to support prevention or early diagnosis of future cancer following urgent referral: A qualitative study Open
View article: The Interface Between Colon Cancer and Mental Health Morbidities
The Interface Between Colon Cancer and Mental Health Morbidities Open
Sara Benitez Majano, PhD; Georgios Lyratzopoulos, MD; Niek J. de Wit, PhD; Becky White, MPhil; Bernard Rachet, PhD; Charles Helsper, PhD; Juliet Usher-Smith, PhD; Cristina Renzi, PhD
View article: Diagnosis; Still Our Achilles Heel?
Diagnosis; Still Our Achilles Heel? Open
View article: Cervical screening: the evolving landscape
Cervical screening: the evolving landscape Open
Background Granzyme B is a key effector of cytotoxic T lymphocytes (CTLs), and its expression level positively correlates with the response of patients with mesothelioma to immune checkpoint inhibitor immunotherapy. Whether metabolic pathw…
View article: Non-speculum clinician-taken samples for human papillomavirus testing: a cross-sectional study in older women
Non-speculum clinician-taken samples for human papillomavirus testing: a cross-sectional study in older women Open
Background Cervical cancer incidence and mortality are high in women aged ≥65 years, despite the disease being preventable by screening. Speculum-based screening can become more uncomfortable after the menopause. Aim To examine test perfor…
View article: Atrial fibrillation: NICE 2021 update and the focus on anticoagulation
Atrial fibrillation: NICE 2021 update and the focus on anticoagulation Open
View article: Associations between general practice characteristics and chest X-ray rate: an observational study
Associations between general practice characteristics and chest X-ray rate: an observational study Open
Background Chest X-ray (CXR) is the first-line test for lung cancer in many settings. Previous research has suggested that higher utilisation of CXR is associated with improved outcomes. Aim To explore the associations between characterist…
View article: Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review
Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review Open
Background National targets for timely diagnosis and management of a potential cancer are driven in part by the perceived risk of disease progression during avoidable delays. However, it is unclear to what extent time-to-treatment impacts …
View article: Venous thromboembolism management and the new NICE guidance: what the busy GP needs to know
Venous thromboembolism management and the new NICE guidance: what the busy GP needs to know Open
This article summarises the 2020 National Institute for Health and Care Excellence (NICE) venous thromboembolism (VTE) guidelines, which are also covered in Royal College of General Practitioners (RCGP) Essential Knowledge Updates (EKU) e-…
View article: Cancer detection via primary care urgent referral and association with practice characteristics: a retrospective cross-sectional study in England from 2009/2010 to 2018/2019
Cancer detection via primary care urgent referral and association with practice characteristics: a retrospective cross-sectional study in England from 2009/2010 to 2018/2019 Open
Background There is substantial variation in the use of urgent suspected cancer referral (2-week wait [2WW]) between practices. Aim To examine the change in use of 2WW referrals in England over 10 years (2009/2010 to 2018/2019) and the pra…
View article: COVID-19 and the multidisciplinary care of patients with lung cancer: an evidence-based review and commentary
COVID-19 and the multidisciplinary care of patients with lung cancer: an evidence-based review and commentary Open
View article: Primary care funding entrenches health inequalities: time for a rethink
Primary care funding entrenches health inequalities: time for a rethink Open
Fifty years since the term was first used to describe the mismatch between healthcare provision and healthcare need,1 the inverse care law is alive and well. Coined by Julian Tudor Hart, a GP in a coal-mining community in south Wales, the …
View article: Highlights
Highlights Open
One of the challenges of reshaping primary care is the ever-present fear of unintended consequences -it brings to mind the analogy of rebuilding a jumbo jet full of people in mid-flight.Do we target specific groups?The editorial by Gina Ag…
View article: Highlights
Highlights Open
Diagnosis isn't always easy.Editorials this month help shine a light on early diagnosis of lung cancer and the complexities of pointof-care testing.We have research on the implications of thrombocytosis and its causes, plus a systematic re…
View article: Highlights
Highlights Open
A trio of editorials shine their light on ongoing COVID-19 concerns; Pate et al describe the impact of NICE dropping the threshold for statins; more research shows HRT prescribing is predicated on socioeconomic status; and we present evide…
View article: Association between use of urgent suspected cancer referral and mortality and stage at diagnosis: a 5-year national cohort study
Association between use of urgent suspected cancer referral and mortality and stage at diagnosis: a 5-year national cohort study Open
Background There is considerable variation between GP practices in England in their use of urgent referral pathways for suspected cancer. Aim To determine the association between practice use of urgent referral and cancer stage at diagnosi…
View article: Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review
Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review Open