Thomas Ruhnke
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View article: Concept and feasibility of privacy-preserving record linkage of cancer registry data and claims data in Germany: results from the DigiNet study on stage IV non-small cell lung cancer
Concept and feasibility of privacy-preserving record linkage of cancer registry data and claims data in Germany: results from the DigiNet study on stage IV non-small cell lung cancer Open
Objective While cancer registry and health insurance data are valuable resources for oncological health services research, these are rarely linked at the individual level due to data protection concerns and technical limitations. The prosp…
View article: Comparison of survival in ovarian cancer patients following treatment in certified gynecologic oncology centers and non-certified hospitals: a German retrospective cohort study (WiZen)
Comparison of survival in ovarian cancer patients following treatment in certified gynecologic oncology centers and non-certified hospitals: a German retrospective cohort study (WiZen) Open
View article: Long-term outcomes after intensive care unit-treated COVID-19, influenza and respiratory sepsis in 2020 – a comparative, population-based cohort study
Long-term outcomes after intensive care unit-treated COVID-19, influenza and respiratory sepsis in 2020 – a comparative, population-based cohort study Open
Background Sepsis survivors are affected by a broad spectrum of long-term impairments, which overlap with Long-Covid and sequelae after influenza in their clinical presentation. However, we lack comparative assessments on the burden of lon…
View article: Rehospitalizations for ambulatory care sensitive conditions in sepsis survivors– a nationwide cohort study using health claims data 2016–2019
Rehospitalizations for ambulatory care sensitive conditions in sepsis survivors– a nationwide cohort study using health claims data 2016–2019 Open
Purpose Sepsis survivors suffer from frequent rehospitalizations, of which a certain proportion is considered preventable by timely and adequate management in the outpatient setting (= ambulatory care sensitive conditions, ACSC). We aimed …
View article: Transitional care after hospitalization for sepsis in Germany– results from the population-based AVENIR cohort study
Transitional care after hospitalization for sepsis in Germany– results from the population-based AVENIR cohort study Open
Purpose Sepsis survivorship is associated with significant long-term morbidity, mortality and health care utilization. Transitional care between inpatient and follow-up care is crucial, but insufficiently understood. We investigated health…
View article: Bildung einer Kohorte zur Untersuchung der medizinischen Versorgung nach einer Krebserkrankung im Kindes- oder Jugendalter (VersKiK-Kohorte) mittels Record-Linkage zwischen Deutschem Kinderkrebsregister und gesetzlichen Krankenkassen
Bildung einer Kohorte zur Untersuchung der medizinischen Versorgung nach einer Krebserkrankung im Kindes- oder Jugendalter (VersKiK-Kohorte) mittels Record-Linkage zwischen Deutschem Kinderkrebsregister und gesetzlichen Krankenkassen Open
Zusammenfassung Im Projekt VersKiK sollen durch Verlinkung von Daten des Deutschen Kinderkrebsregisters mit Routinedaten gesetzlicher Krankenkassen die Art und Häufigkeit von Spätfolgen und die medizinische Versorgung von Langzeitüberleben…
View article: Correction: Endometrial Cancer – Long-Term Survival in Certified Cancer Centers and Non-Certified Hospitals
Correction: Endometrial Cancer – Long-Term Survival in Certified Cancer Centers and Non-Certified Hospitals Open
View article: Strukturierte Ersteinschätzung in der Notaufnahme mittels des intelligenten Assistenzdienstes OPTINOFA
Strukturierte Ersteinschätzung in der Notaufnahme mittels des intelligenten Assistenzdienstes OPTINOFA Open
Zusammenfassung Die Organisation der Notfallversorgung in Deutschland bedarf einer grundlegenden Reform. Die Steuerung der Patientenströme in den ambulanten bzw. stationären Sektor stellt hierbei eine der zentralen Herausforderungen dar. I…
View article: Sex-specific outcomes in acute myocardial infarction-associated cardiogenic shock treated with and without V-A ECMO: a retrospective German nationwide analysis from 2014 to 2018
Sex-specific outcomes in acute myocardial infarction-associated cardiogenic shock treated with and without V-A ECMO: a retrospective German nationwide analysis from 2014 to 2018 Open
Acute myocardial infarction-associated cardiogenic shock (AMICS) remains a condition with high mortality. Some patients require mechanical circulatory support (MCS) as their condition deteriorates. Sex-specific differences in risk factors …
View article: Characterising HIV-Indicator conditions among two nationwide long-term cohorts of people living with HIV in Germany (1999–2023)
Characterising HIV-Indicator conditions among two nationwide long-term cohorts of people living with HIV in Germany (1999–2023) Open
Background/Objective Information about occurrence and affected groups of symptoms/diagnoses indicative of an HIV infection (so-called HIV indicator conditions; HIV-ICs) is lacking. We analyse HIV-IC incidence, transmission risks and immune…
View article: Endometrial Cancer – Long-Term Survival in Certified Cancer Centers and Non-Certified Hospitals
Endometrial Cancer – Long-Term Survival in Certified Cancer Centers and Non-Certified Hospitals Open
Introduction Endometrial cancer is the most common malignant tumor of the female genital organs. In Germany, treatment is provided in both cancer centers certified by the German Cancer Society (Deutsche Krebsgesellschaft, DKG) and in non-c…
View article: Impact of Guideline-Directed Drug Therapy after ST-Elevation Myocardial Infarction on Outcome in Young Patients—Age and Sex-Specific Factors
Impact of Guideline-Directed Drug Therapy after ST-Elevation Myocardial Infarction on Outcome in Young Patients—Age and Sex-Specific Factors Open
Background: Specifically young women are at risk for a poor outcome after ST-elevation myocardial infarction (STEMI). We aimed to investigate sex- and age-specific differences in outcome and associate these results with adherence to a guid…
View article: Prevalence of HIV in people with potential HIV-indicator conditions in Germany: an analysis of data from statutory health insurances
Prevalence of HIV in people with potential HIV-indicator conditions in Germany: an analysis of data from statutory health insurances Open
This analysis is part of the HIV testing recommendations in guidelines and practice study (German title of the study: "HIV-Testempfehlungen in Leitlinien und Praxis"; acronym: HeLP), which is funded by the German Federal Joint Committee as…
View article: Die Behandlung in zertifizierten Brustkrebszentren verbessert die Überlebenschancen von Patient*innen mit Brustkrebs
Die Behandlung in zertifizierten Brustkrebszentren verbessert die Überlebenschancen von Patient*innen mit Brustkrebs Open
Zusammenfassung Zertifizierte Brustkrebszentren bieten spezifische Qualitätsstandards für die Struktur, Diagnostik und Behandlungsverfahren, beispielsweise der Mammachirurgie, medikamentösen Tumortherapie, Strahlentherapie und psychosozial…
View article: Die Behandlung in zertifizierten Brustkrebszentren verbessert die Überlebenschancen von Patient*innen mit Brustkrebs
Die Behandlung in zertifizierten Brustkrebszentren verbessert die Überlebenschancen von Patient*innen mit Brustkrebs Open
Zusammenfassung Zertifizierte Brustkrebszentren bieten spezifische Qualitätsstandards für die Struktur, Diagnostik und Behandlungsverfahren, beispielsweise der Mammachirurgie, medikamentösen Tumortherapie, Strahlentherapie und psychosozial…
View article: BMI-Stratified Exploration of the ‘Obesity Paradox’: Heart Failure Perspectives from a Large German Insurance Database
BMI-Stratified Exploration of the ‘Obesity Paradox’: Heart Failure Perspectives from a Large German Insurance Database Open
Background: The global rise of obesity and its association with cardiovascular risk factors (CVRF) have highlighted its connection to chronic heart failure (CHF). Paradoxically, obese CHF patients often experience better outcomes, a phenom…
View article: Complications and Outcomes in 39,864 Patients Receiving Standard Care Plus Mechanical Circulatory Support or Standard Care Alone for Infarct-Associated Cardiogenic Shock
Complications and Outcomes in 39,864 Patients Receiving Standard Care Plus Mechanical Circulatory Support or Standard Care Alone for Infarct-Associated Cardiogenic Shock Open
Background: Temporary mechanical circulatory support devices (tMCS) are increasingly being used in patients with infarct-associated cardiogenic shock (AMICS). Evidence on patient selection, complications and long-term outcomes is lacking. …
View article: Treatment in Certified Breast Cancer Centers Improves Chances of Survival of Patients with Breast Cancer
Treatment in Certified Breast Cancer Centers Improves Chances of Survival of Patients with Breast Cancer Open
Certified breast cancer centers offer specific quality standards in terms of their structure, diagnostic and treatment approaches with regards to breast surgery, drug-based cancer therapy, radiotherapy, and psychosocial support. Such cente…
View article: Understanding health care pathways of patients with sepsis: protocol of a mixed-methods analysis of health care utilization, experiences, and needs of patients with and after sepsis
Understanding health care pathways of patients with sepsis: protocol of a mixed-methods analysis of health care utilization, experiences, and needs of patients with and after sepsis Open
View article: Treatment in certified cancer centers is related to better survival in patients with colon and rectal cancer: evidence from a large German cohort study
Treatment in certified cancer centers is related to better survival in patients with colon and rectal cancer: evidence from a large German cohort study Open
Background Certified cancer centers aim to ensure high-quality care by establishing structural and procedural standards according to evidence-based guidelines. Despite the high clinical and health policy relevance, evidence from a nation-w…
View article: Sex aspects of guideline-directed therapy in young ST- elevation myocardial infarction patients
Sex aspects of guideline-directed therapy in young ST- elevation myocardial infarction patients Open
Background Young women are at specific risk for a poor outcome after ST- elevation myocardial infarction (STEMI). We aimed to investigate sex- and age-specific differences in adherence to a guideline-directed drug therapy for secondary pro…
View article: Survival of Patients with Acute Coronary Syndrome and Hematologic Malignancies—A Real-World Analysis
Survival of Patients with Acute Coronary Syndrome and Hematologic Malignancies—A Real-World Analysis Open
Background: The impact of the encounter between coronary heart disease (CHD) and cancer, and in particular hematologic malignancies (HM), remains poorly understood. Objective: The aim of this analysis was to clarify how HM affects the prog…
View article: Assessing the Use of German Claims Data Vocabularies for Research in the Observational Medical Outcomes Partnership Common Data Model: Development and Evaluation Study
Assessing the Use of German Claims Data Vocabularies for Research in the Observational Medical Outcomes Partnership Common Data Model: Development and Evaluation Study Open
Background National classifications and terminologies already routinely used for documentation within patient care settings enable the unambiguous representation of clinical information. However, the diversity of different vocabularies acr…
View article: Contemporary secondary prevention in survivors of ST-elevation myocardial infarction with and without chronic kidney disease: a retrospective analysis
Contemporary secondary prevention in survivors of ST-elevation myocardial infarction with and without chronic kidney disease: a retrospective analysis Open
Background Survivors of myocardial infarction have an elevated risk of long-term mortality. We sought to evaluate guideline-directed medical treatment and its impact on long-term mortality in survivors of ST-elevation myocardial infarction…
View article: Optimization of HIV testing services in Germany using HIV indicator diseases: study protocol of the HeLP study
Optimization of HIV testing services in Germany using HIV indicator diseases: study protocol of the HeLP study Open
Background Despite the potentially accompanying negative clinical, epidemiologic, and health economic effects, a large proportion of persons living with the human immunodeficiency virus (HIV) are diagnosed late. Internationally, numerous d…
View article: Initial cancer treatment in certified versus non-certified hospitals
Initial cancer treatment in certified versus non-certified hospitals Open
The WiZen study shows for the entities studied that initial cancer treatment in a certified center is associated with lower mortality. Despite the recommendations of the National Cancer Plan, however, more than 40% of all cancer patients s…
View article: DS-Demenz – (Zugang zur) Diagnostik und Therapie demenzieller Erkrankungen bei Menschen mit einem Down-Syndrom – Ein Scoping Review
DS-Demenz – (Zugang zur) Diagnostik und Therapie demenzieller Erkrankungen bei Menschen mit einem Down-Syndrom – Ein Scoping Review Open
View article: HIV-Indikatorerkrankungen in Deutschland – Studienprotokoll der HeLP-Studie
HIV-Indikatorerkrankungen in Deutschland – Studienprotokoll der HeLP-Studie Open
Einleitung In Deutschland wird bei schätzungsweise 44% bis 64% der HIV-positiven Personen die Infektion erst mit deutlichem Zeitverzug diagnostiziert. Auch wissen etwa 10% der HIV-positiven Personen in Deutschland nicht um ihre HIV-Infekti…
View article: Menschen mit Down-Syndrom und Demenz: Darstellung der Versorgungssituation anhand einer Routinedatenauswertung
Menschen mit Down-Syndrom und Demenz: Darstellung der Versorgungssituation anhand einer Routinedatenauswertung Open
Einleitung Menschen mit Down-Syndrom (MmDS) haben genetisch bedingt ein stark erhöhtes Risiko, an einer frühen Alzheimer-Demenz zu erkranken. Im Vergleich zur Allgemeinbevölkerung ergeben sich in der Diagnostik und Therapie bei MmDS jedoch…
View article: German Claims Data for Real-World Research: Content Coverage Evaluation in OMOP CDM
German Claims Data for Real-World Research: Content Coverage Evaluation in OMOP CDM Open
Research on real-world data is becoming increasingly important. The current restriction to clinical data in Germany limits the view of the patient. To gain comprehensive insights, claims data can be added to the existing knowledge. However…