Thomas Scheibel
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View article: Wrinkling‐Based Patterning and Recombinant Spider Silk‐Based Coating Technologies ‐ Toward Novel Applications
Wrinkling‐Based Patterning and Recombinant Spider Silk‐Based Coating Technologies ‐ Toward Novel Applications Open
Wrinkling, formed by stress‐induced energy minimization in thin polymer films, provides a reproducible method for large‐area surface patterning. The resulting nano/micro topographies allow controlled spatial organization of nanomaterials f…
View article: Fiber Reinforcement of Soft Spider Silk Hydrogels
Fiber Reinforcement of Soft Spider Silk Hydrogels Open
Recombinant spider silk‐based biomaterials show high application potential due to their biocompatibility, biodegradability, and low immunogenicity. Self‐assembly of monomeric proteins into nanofibrils is necessary toward hydrogel formation…
View article: ROS‐Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing
ROS‐Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing Open
Chronic wounds often experience delayed healing due to a disrupted microenvironment marked by persistent inflammation and excessive fibrosiswhich leads to tissue dysfunction. Excessive mitochondrial reactive oxygen species (ROS) at the inj…
View article: Immobilization of Photocatalysts on Spider Silk-Based Membranes for Continuous Hydrogen Production
Immobilization of Photocatalysts on Spider Silk-Based Membranes for Continuous Hydrogen Production Open
The demand for green and sustainable energy sources is rapidly increasing. Hydrogen is an emission-less energy source, but current production methods are energy-consuming, making hydrogen in part unattractive compared to conventional energ…
View article: Bridging the Gap: Unlocking the Potential of Biofabrication for Applications in In Vitro Testing
Bridging the Gap: Unlocking the Potential of Biofabrication for Applications in In Vitro Testing Open
Biofabrication holds immense potential for advancing tissue models used in in vitro testing. Despite significant technological advancements, there are currently no commercially viable biofabricated in vitro models, e.g., for drug testing. …
View article: Nanostructured Protein Surfaces Inspired by Spider Silk
Nanostructured Protein Surfaces Inspired by Spider Silk Open
Spider silk is renowned for its exceptional mechanical properties, surpassing those of many natural and synthetic materials. This review focuses on biotechnologically produced recombinant spidroin variants inspired by well‐understood major…
View article: Robust <i>β</i>‐Sheet Peptide Reinforced Polymer Fibers
Robust <i>β</i>‐Sheet Peptide Reinforced Polymer Fibers Open
In natural silks, β ‐sheet crystals are embedded within an amorphous matrix resulting in polypeptide‐based nanocomposites. These β ‐sheet crystals contribute to the subsequent high strength and toughness of spider silk. Consequently, imita…
View article: Liquid‒liquid phase separation of spider silk proteins
Liquid‒liquid phase separation of spider silk proteins Open
Liquid‒liquid phase separation (LLPS) is a phenomenon relevant in the multicomponent settings of many biological processes, including compartmentation, pathological conditions such as Alzheimer’s disease, and protein assembly. LLPS also pl…
View article: Fiber Processing of Recombinant Spider Silk Proteins
Fiber Processing of Recombinant Spider Silk Proteins Open
Spider silks are protein‐based fibers well known for their tensile strength, elasticity, and extraordinary toughness. However, spider silk has not yet been found to enter many products, since harvesting natural spider silk is highly ineffi…
View article: RETRACTED: Spider Eye Development Editing and Silk Fiber Engineering Using CRISPR‐Cas
RETRACTED: Spider Eye Development Editing and Silk Fiber Engineering Using CRISPR‐Cas Open
CRISPR‐Cas9 gene editing represents an effective and precise technology to induce mutations in the genome, and it has been applied to a wide range of organisms for diverse purposes. However, CRISPR‐based gene editing in spiders has not bee…
View article: Enhancing Form Stability: Shrink‐Resistant Hydrogels Made of Interpenetrating Networks of Recombinant Spider Silk and Collagen‐I
Enhancing Form Stability: Shrink‐Resistant Hydrogels Made of Interpenetrating Networks of Recombinant Spider Silk and Collagen‐I Open
Tissue engineering enables the production of tissues and organ‐like structures as models for drug testing and mechanistical studies or functional replacements for injured tissues. Available cytocompatible materials are limited in number, s…
View article: Inhibition of Biofilm Formation on Orthopedic Implants Based on Spider Silk Coatings Increases Survival of <i>Galleria mellonella</i>
Inhibition of Biofilm Formation on Orthopedic Implants Based on Spider Silk Coatings Increases Survival of <i>Galleria mellonella</i> Open
The microbial repellence of some spider silk‐based materials makes them interesting candidates for biomedical applications. This study investigates the microbial repellent properties of recombinant spider silk coatings on orthopedic metal …
View article: In Vivo Vascularization of Cell-Supplemented Spider Silk-Based Hydrogels in the Arteriovenous Loop Model
In Vivo Vascularization of Cell-Supplemented Spider Silk-Based Hydrogels in the Arteriovenous Loop Model Open
The goal of reconstructive surgery in treating tissue defects is to achieve a stable reconstructive outcome while minimizing donor site morbidity. As a result, tissue engineering has emerged as a key focus in the pursuit of this goal. One …
View article: Cocktail Polyplexes With Synchronous Flightless I siRNA and Nitric Oxide Release for Potential Chronic Wound Healing
Cocktail Polyplexes With Synchronous Flightless I siRNA and Nitric Oxide Release for Potential Chronic Wound Healing Open
Chronic wounds are one of the health challenges threatening human life. In these wounds, overexpression of some types of cytoskeletal actin‐remodeling proteins including Flightless I (Flii) can often lead to severe skin scarring. Herein, a…
View article: 3D‐Printed and Recombinant Spider Silk Particle Reinforced Collagen Composite Scaffolds for Soft Tissue Engineering
3D‐Printed and Recombinant Spider Silk Particle Reinforced Collagen Composite Scaffolds for Soft Tissue Engineering Open
Collagen is one main component of the extracellular matrix (ECM) in natural tissues and is, therefore, well suited as a biomaterial for tissue engineering. In this study, a method is presented to 3D‐bioprint collagen into a precipitation b…
View article: Enhanced photocatalytic performance of coaxially electrospun titania nanofibers comprising yolk-shell particles
Enhanced photocatalytic performance of coaxially electrospun titania nanofibers comprising yolk-shell particles Open
The present paper reports the fabrication of novel types of hybrid fibrous photocatalysts by combining block copolymer (BCP) templating, sol-gel processing, and coaxial electrospinning techniques. Coaxial electrospinning produces core-shel…
View article: Bioinspired and biomimetic protein-based fibers and their applications
Bioinspired and biomimetic protein-based fibers and their applications Open
Protein-based fibers combine unique mechanical properties with biocompatibility and biodegradability, and often outperform polymer-based fibers. Furthermore, a growing need for sustainable materials has triggered a revival in the study of …
View article: Multifunctional naturally derived bioadhesives: From strategic molecular design toward advanced biomedical applications
Multifunctional naturally derived bioadhesives: From strategic molecular design toward advanced biomedical applications Open
In the last decades, adhesives derived from natural resources (i.e., bioadhesives) have emerged as promising alternative to the standard wound closure devices, including sutures, clips, and strips, owing to relatively easy and rapid applic…
View article: Impact of environmental factors on spider silk properties
Impact of environmental factors on spider silk properties Open
Spider orb webs have evolved to stop flying prey, fast and slow alike. One of the main web elements dissipating impact energy is the radial fibers, or major ampullate silks, which possess a toughness surpassing most man-made materials. Orb…
View article: Influence of the Sequence Motive Repeating Number on Protein Folding in Spider Silk Protein Films
Influence of the Sequence Motive Repeating Number on Protein Folding in Spider Silk Protein Films Open
Like multiblock copolymers, spider silk proteins are built of repetitive sequence motives. One prominent repetitive motif is based on the consensus sequence of spidroin 4 of the spider Araneus diadematus ADF4. The number x of the repeating…
View article: Designte Spinnenseidenmaterialien für zellspezifische Interaktionen
Designte Spinnenseidenmaterialien für zellspezifische Interaktionen Open
Spider silk films are promising for regenerative medicine and tissue engineering due to their biocompatibility. However, without modifications spider silk films often interact little with cells. Thus, we developed two modification strategi…
View article: On the reproducibility of extrusion-based bioprinting: round robin study on standardization in the field
On the reproducibility of extrusion-based bioprinting: round robin study on standardization in the field Open
The outcome of three-dimensional (3D) bioprinting heavily depends, amongst others, on the interaction between the developed bioink, the printing process, and the printing equipment. However, if this interplay is ensured, bioprinting promis…
View article: Factors Influencing Properties of Spider Silk Coatings and Their Interactions within a Biological Environment
Factors Influencing Properties of Spider Silk Coatings and Their Interactions within a Biological Environment Open
Biomaterials are an indispensable part of biomedical research. However, although many materials display suitable application-specific properties, they provide only poor biocompatibility when implanted into a human/animal body leading to in…
View article: Suitable electrospinning approaches for recombinant spider silk proteins
Suitable electrospinning approaches for recombinant spider silk proteins Open
Among the versatile opportunities of processing recombinant spider silk proteins into coatings, hydrogels, particles, fibrils and foams, electrospinning provides a further highly important morphology: submicron- and nanofibers. These fiber…
View article: Rheological and Biological Impact of Printable PCL‐Fibers as Reinforcing Fillers in Cell‐Laden Spider‐Silk Bio‐Inks
Rheological and Biological Impact of Printable PCL‐Fibers as Reinforcing Fillers in Cell‐Laden Spider‐Silk Bio‐Inks Open
The development of bio‐inks capable of being 3D‐printed into cell‐containing bio‐fabricates with sufficient shape fidelity is highly demanding. Structural integrity and favorable mechanical properties can be achieved by applying high polym…
View article: Bio‐inspired Protein‐Based and Activatable Adhesion Systems
Bio‐inspired Protein‐Based and Activatable Adhesion Systems Open
Adhesives are in general chemically or physically sticky substances used to join surfaces. In case of gluing biological and living substrates, there is a need for bioadhesives that meet requirements such as biocompatibility, non‐toxicity, …
View article: Biomimetic polymer fibers—function by design
Biomimetic polymer fibers—function by design Open
Biomimicry applies the fundamental principles of natural materials, processes, and structures to technological applications. This review presents the two strategies of biomimicry—bottom-up and top-down approaches, using biomimetic polymer …
View article: Polystyrene microparticle distribution after ingestion by murine macrophages
Polystyrene microparticle distribution after ingestion by murine macrophages Open
The impact of microplastic particles on organisms is currently intensely researched. Although it is well established that macrophages ingest polystyrene (PS) microparticles, little is known about the subsequent fate of the particles, such …