Thomas Scheike
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View article: Lifestyle factors, metabolic syndrome and apolipoprotein E in monozygotic twins with, at risk of and without affective disorders, as predictors of onset or recurrence of affective episodes, a seven-years follow-up study
Lifestyle factors, metabolic syndrome and apolipoprotein E in monozygotic twins with, at risk of and without affective disorders, as predictors of onset or recurrence of affective episodes, a seven-years follow-up study Open
The established risk genotypes APOE ε43 and ε44 were linked to the onset and recurrence of affective disorders in both affected and high-risk twins. Body mass index and smoking also emerged as significant risk factors. Furthermore, the pre…
View article: Risk of rhegmatogenous retinal detachment following pars plana vitrectomy for full‐thickness macular hole and epiretinal membrane in pseudophakic eyes
Risk of rhegmatogenous retinal detachment following pars plana vitrectomy for full‐thickness macular hole and epiretinal membrane in pseudophakic eyes Open
Purpose To estimate the risk of rhegmatogenous retinal detachment (RRD) following pars plana vitrectomy (PPV) for full‐thickness macular hole (FTMH) or epiretinal membrane (ERM) in pseudophakic eyes. Methods We conducted a nationwide Danis…
View article: The burden of somatic comorbidities in patients surviving a traumatic brain injury
The burden of somatic comorbidities in patients surviving a traumatic brain injury Open
Background The long-term development of somatic comorbidities in patients surviving a traumatic brain injury (TBI) may contribute to both the individual and public health burden; however, a systematic investigation has not yet been underta…
View article: Theory for tunnel magnetoresistance oscillation
Theory for tunnel magnetoresistance oscillation Open
The universal oscillation of the tunnel magnetoresistance (TMR) ratio as a function of the insulating barrier thickness in crystalline magnetic tunnel junctions (MTJs) is a long-standing unsolved problem in condensed matter physics. To exp…
View article: Socioeconomic characteristics and relapse-free and overall survival from childhood cancer – a nationwide study based on data from the Danish Childhood Cancer Registry
Socioeconomic characteristics and relapse-free and overall survival from childhood cancer – a nationwide study based on data from the Danish Childhood Cancer Registry Open
Background and purpose: Over the past decades, childhood cancer survival has increased substantially in Europe, including Denmark. However, families with fewer social resources may have benefitted less from these improvements. In this nati…
View article: 1.35% Taurolidine Prevents Recurrent Catheter-Related Bloodstream Infections In Chronic Intestinal Failure Patients; A Randomized Controlled Trial
1.35% Taurolidine Prevents Recurrent Catheter-Related Bloodstream Infections In Chronic Intestinal Failure Patients; A Randomized Controlled Trial Open
View article: Development and Validation of the Crohn’s Disease-Intestinal Failure-Wean Score to Predict Outcomes of Intestinal Rehabilitation
Development and Validation of the Crohn’s Disease-Intestinal Failure-Wean Score to Predict Outcomes of Intestinal Rehabilitation Open
View article: Development and validation of the Crohn's disease-intestinal failure-wean (CDIF-Wean) Score to predict outcomes of intestinal rehabilitation
Development and validation of the Crohn's disease-intestinal failure-wean (CDIF-Wean) Score to predict outcomes of intestinal rehabilitation Open
The CDIF-Wean Score is the first validated prediction model for IF outcomes, and demonstrates accuracy, robustness and generalisability in the prognostication of CDIF patients.
View article: Nonparametric estimation of the Patient Weighted While-Alive Estimand
Nonparametric estimation of the Patient Weighted While-Alive Estimand Open
In clinical trials with recurrent events, such as repeated hospitalizations terminating with death, it is important to consider the patient events overall history for a thorough assessment of treatment effects. The occurrence of fewer even…
View article: Sagittal Knee Gait Changes After Medial Unicompartmental and Total Knee Arthroplasty: An Exploratory Analysis of 32 Patients
Sagittal Knee Gait Changes After Medial Unicompartmental and Total Knee Arthroplasty: An Exploratory Analysis of 32 Patients Open
We observed significant developments in sagittal knee gait after knee arthroplasty. Patients developed faster walking speed and greater stride frequency, as well as improvements in the range of motion, sagittal knee angle velocities, and a…
View article: The Natural History of Crohn’s Disease Leading to Intestinal Failure: A Longitudinal Cohort Study from 1973 to 2018
The Natural History of Crohn’s Disease Leading to Intestinal Failure: A Longitudinal Cohort Study from 1973 to 2018 Open
Background and Aims: The natural history of Crohn’s disease leading to intestinal failure is not well characterised. This study aims to describe the clinical course of Crohn’s disease preceding intestinal failure, and compare disease activ…
View article: Propensity weighting plus adjustment in proportional hazards model is not doubly robust
Propensity weighting plus adjustment in proportional hazards model is not doubly robust Open
Recently, it has become common for applied works to combine commonly used survival analysis modeling methods, such as the multivariable Cox model and propensity score weighting, with the intention of forming a doubly robust estimator of an…
View article: APOE Genotype, ApoE Plasma Levels, Lipid Metabolism, and Cognition in Monozygotic Twins with, at Risk of, and without Affective Disorders
APOE Genotype, ApoE Plasma Levels, Lipid Metabolism, and Cognition in Monozygotic Twins with, at Risk of, and without Affective Disorders Open
Background: Lipids influence brain function and mental health. Understanding the role of apolipoproteins in affective disorders could provide valuable insights and potentially pave the way for novel therapeutic approaches. Methods: We exam…
View article: Simulation‐based sample size calculations of marginal proportional means models for recurrent events with competing risks
Simulation‐based sample size calculations of marginal proportional means models for recurrent events with competing risks Open
In randomised controlled trials, the outcome of interest could be recurrent events, such as hospitalisations for heart failure. If mortality rates are non‐negligible, both recurrent events and competing terminal events need to be addressed…
View article: Sagittal knee gait changes after medial unicompartmental and total knee arthroplasty – an exploratory analysis of 36 patients
Sagittal knee gait changes after medial unicompartmental and total knee arthroplasty – an exploratory analysis of 36 patients Open
This study aimed to investigate postoperative developments of sagittal knee gait in a population of knee arthroplasty patients randomized to either unicompartmental or total knee arthroplasty. We hypothesized that knee arthroplasty patient…
View article: P1118 High Crohn’s Disease burden but disproportionally low use of biologics in Crohn’s Disease patients with Intestinal Failure: a longitudinal comparative study from 1973-2018
P1118 High Crohn’s Disease burden but disproportionally low use of biologics in Crohn’s Disease patients with Intestinal Failure: a longitudinal comparative study from 1973-2018 Open
Background Patients with Crohn’s Disease (CD) complicated by Intestinal Failure (CDIF) are considered to be among those with the most severe form of CD. Their clinical course before IF onset has not been well characterised. We aimed to des…
View article: P1100 A multivariate time-dependent proportional hazard model to predict development of intestinal failure from Crohn’s Disease
P1100 A multivariate time-dependent proportional hazard model to predict development of intestinal failure from Crohn’s Disease Open
Background Intestinal Failure (IF) is a rare but severe complication of Crohn’s disease (CD). Advancement in therapy has not eliminated incident IF from CD (CDIF), and risk factors for developing IF from CD are not well characterised. The …
View article: Propensity weighting plus adjustment in proportional hazards model is not doubly robust
Propensity weighting plus adjustment in proportional hazards model is not doubly robust Open
Recently, it has become common for applied works to combine commonly used survival analysis modeling methods, such as the multivariable Cox model and propensity score weighting, with the intention of forming a doubly robust estimator of an…
View article: Interpretability – using causal modeling frameworks to investigate the association between long-term exposure to nitrogen dioxide and COVID-19 disease
Interpretability – using causal modeling frameworks to investigate the association between long-term exposure to nitrogen dioxide and COVID-19 disease Open
View article: Unbiased and efficient estimation of causal treatment effects in crossover trials
Unbiased and efficient estimation of causal treatment effects in crossover trials Open
We introduce causal inference reasoning to crossover trials, with a focus on thorough QT (TQT) studies. For such trials, we propose different sets of assumptions and consider their impact on the modeling strategy and estimation procedure. …
View article: Prediction of herpes virus infections after solid organ transplantation: a prospective study of immune function
Prediction of herpes virus infections after solid organ transplantation: a prospective study of immune function Open
Introduction Herpes virus infections are a major concern after solid organ transplantation and linked to the immune function of the recipient. We aimed to determine the incidence of positive herpes virus (cytomegalovirus (CMV), Epstein-Bar…
View article: Efficient t0$$ {t}_0 $$‐year risk regression using the logistic model
Efficient t0$$ {t}_0 $$‐year risk regression using the logistic model Open
In some clinical studies patient survival beyond a specific point in time, , say, may be of special interest as it may for instance indicate patient cure. To analyze the ‐year risk for such patients may be accomplished using logistic regre…
View article: Efficient Estimation of the Marginal Mean of Recurrent Events
Efficient Estimation of the Marginal Mean of Recurrent Events Open
Recurrent events are often encountered in clinical and epidemiological studies where a terminal event is also observed. With recurrent events data it is of great interest to estimate the marginal mean of the cumulative number of recurrent …
View article: Unbiased and Efficient Estimation of Causal Treatment Effects in Cross-over Trials
Unbiased and Efficient Estimation of Causal Treatment Effects in Cross-over Trials Open
We introduce causal inference reasoning to cross-over trials, with a focus on Thorough QT (TQT) studies. For such trials, we propose different sets of assumptions and consider their impact on the modelling strategy and estimation procedure…
View article: Efficient Estimation in the Fine and Gray Model
Efficient Estimation in the Fine and Gray Model Open
Direct regression for the cumulative incidence function (CIF) has become increasingly popular since the Fine and Gray model was suggested (Fine and Gray) due to its more direct interpretation on the probability risk scale. We here consider…
View article: Giant oscillatory tunnel magnetoresistance in CoFe/MgO/CoFe(001) junctions
Giant oscillatory tunnel magnetoresistance in CoFe/MgO/CoFe(001) junctions Open
The tunnel magnetoresistance (TMR) effect observed in magnetic tunnel junctions (MTJs) is commonly used in many spintronic applications because the effect can easily convert from local magnetic states to electric signals in a wide range of…
View article: Weight change during the first week of life and a new method for retrospective prediction of birthweight among exclusively breastfed newborns
Weight change during the first week of life and a new method for retrospective prediction of birthweight among exclusively breastfed newborns Open
Introduction Identification of low birthweight and small for gestational age is pivotal in clinical management and many research studies, but in low‐income countries, birthweight is often unavailable within 24 h of birth. Newborn weights m…
View article: Sampling in the case‐time‐control design among drug users when outcome prevents further treatment
Sampling in the case‐time‐control design among drug users when outcome prevents further treatment Open
Purpose The objective of this article is to advocate a new way of sampling controls in the case‐time‐control design in a cohort of drug users when the studied outcome prevents further treatment. Methods Mathematically we demonstrate how a …
View article: Familial Risk and Heritability of Cancer Among Twins in Nordic Countries
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries Open
View article: Radiographic Imaging to Evaluate Food Passage Rate in Preterm Piglets as a Model for Preterm Infants
Radiographic Imaging to Evaluate Food Passage Rate in Preterm Piglets as a Model for Preterm Infants Open
Objectives and study: Gut motility in infants mature with increasing post-menstrual age and is affected by numerous hormonal, immunological and nutritional factors. However, it remains unclear how age and diet influence gut motility and it…