Thomas Skoglund
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View article: Genetic Risk Factors for Poor Cognitive Outcome Following Brain Insult—A Systematic Review
Genetic Risk Factors for Poor Cognitive Outcome Following Brain Insult—A Systematic Review Open
Introduction Cognitive outcomes following brain insult are shaped by a range of factors, including genetic predispositions. Emerging evidence indicates that specific genetic variants may affect the susceptibility to cognitive impairment in…
View article: Proteomics in IDH-mutated diffuse lower-grade glioma: a scoping review
Proteomics in IDH-mutated diffuse lower-grade glioma: a scoping review Open
Background Therapeutic options and biomarkers for isocitrate dehydrogenase-mutated (IDHmut) diffuse lower-grade glioma (dLGG), WHO grade 2–3, are limited. Global quantitative proteomics has aided the discovery of novel markers and drug tar…
View article: Brain injury biomarkers and intraoperative hypotension: associations with pituitary hormone deficiency following transsphenoidal endoscopic surgery for non-functioning pituitary adenomas
Brain injury biomarkers and intraoperative hypotension: associations with pituitary hormone deficiency following transsphenoidal endoscopic surgery for non-functioning pituitary adenomas Open
Purpose Factors related to the development of new pituitary hormone deficiencies following transsphenoidal surgery for non-functioning pituitary adenomas are multifactorial and remain poorly understood. We explored associations with brain …
View article: Cognitive function and fatigue before and after transsphenoidal surgery in patients with pituitary adenoma: a prospective study
Cognitive function and fatigue before and after transsphenoidal surgery in patients with pituitary adenoma: a prospective study Open
Purpose The aim of this prospective longitudinal study was to evaluate cognitive function and fatigue before and 12 months after transsphenoidal surgery (TSS) for a pituitary adenoma. Methods This study was part of the Gothenburg Pituitary…
View article: Person-centered support for patients with a pituitary tumor following surgery
Person-centered support for patients with a pituitary tumor following surgery Open
Objectives To evaluate whether a person-centered care practice following surgery for pituitary tumors increased psychological well-being. Secondary aims were to study whether person-centered care would lead to better health status, less fa…
View article: Cognitive function in pituitary adenoma patients: A cross-sectional study
Cognitive function in pituitary adenoma patients: A cross-sectional study Open
Various factors may affect cognition in patients with pituitary adenoma, including size and extension of the tumor, degree of pituitary hormone deficiencies, and treatment of the tumor, most often being transsphenoidal surgery (TSS). The a…
View article: Circulating Brain Injury Biomarkers for Predicting Outcomes Following Elective Neurosurgery: A Scoping Review
Circulating Brain Injury Biomarkers for Predicting Outcomes Following Elective Neurosurgery: A Scoping Review Open
Circulating brain injury biomarkers show promise for providing objective insights into the extent of perioperative brain injury and improving prognostication of postsurgical outcomes. However, the heterogeneity in study designs and outcome…
View article: Health-related quality of life in surgically treated asymptomatic meningioma patients: A population-based matched cohort study
Health-related quality of life in surgically treated asymptomatic meningioma patients: A population-based matched cohort study Open
Background Asymptomatic patients with meningiomas are increasingly detected, where management can be challenging in terms of surgery versus watchful waiting. Health-related quality of life (HRQoL) is an important factor in clinical decisio…
View article: Headache in patients with non-functioning pituitary adenoma before and after transsphenoidal surgery – a prospective study
Headache in patients with non-functioning pituitary adenoma before and after transsphenoidal surgery – a prospective study Open
Purpose To study the long-term effect of transsphenoidal surgery (TSS) on headache in patients with non-functioning pituitary adenoma (NFPA) and identify factors predicting headache relief following TSS. Methods We evaluated headache in 10…
View article: The glymphatic system for neurosurgeons: a scoping review
The glymphatic system for neurosurgeons: a scoping review Open
The discovery of the glymphatic system has revolutionized our understanding of cerebrospinal fluid (CSF) circulation and interstitial waste clearance in the brain. This scoping review aims to synthesize the current literature on the glymph…
View article: Proteomic Profiles Associated With Postsurgical Progression in Nonfunctioning Pituitary Adenomas
Proteomic Profiles Associated With Postsurgical Progression in Nonfunctioning Pituitary Adenomas Open
Context There is a lack of reliable biomarkers capable of predicting postoperative tumor progression of nonfunctioning pituitary adenomas (NFPAs). Objective To discover proteomic profiles associated with postoperative tumor progression in …
View article: SAT615 Long-term Effects Of Transsphenoidal Surgery On Headache In Patients With Pituitary Tumors - A Prospective Study
SAT615 Long-term Effects Of Transsphenoidal Surgery On Headache In Patients With Pituitary Tumors - A Prospective Study Open
Disclosure: V. Hantelius: None. O. Ragnarsson: None. G. Johannsson: None. E. Thurin: None. T. Skoglund: None. T. Hallen: None. Objective: Headache is a common symptom in patients with non-functioning pituitary adenomas (NFPA). The aim of t…
View article: P07.14.A OBSERVATIONS FROM THE FIRST 100 CASES OF INTRAOPERATIVE MRI - EXPERIENCES, TRENDS AND SHORT-TERM OUTCOMES IN PEDIATRIC VERSUS ADULT NEUROSURGICAL POPULATION
P07.14.A OBSERVATIONS FROM THE FIRST 100 CASES OF INTRAOPERATIVE MRI - EXPERIENCES, TRENDS AND SHORT-TERM OUTCOMES IN PEDIATRIC VERSUS ADULT NEUROSURGICAL POPULATION Open
BACKGROUND The intraoperative MRI (iMRI) at Sahlgrenska University Hospital installed in 2017 was the first introduced in Sweden. Herein, we present a single center study with our observations from the first 100 patients undergoing neurosu…
View article: Hypotension during transsphenoidal pituitary surgery associated with increase in plasma levels of brain injury markers
Hypotension during transsphenoidal pituitary surgery associated with increase in plasma levels of brain injury markers Open
Background Patients undergoing pituitary surgery may experience short‐ and long‐term postoperative morbidity. Intraoperative factors such as hypotension might be a contributing factor. Our aim was to investigate the association between int…
View article: Circulating Brain Injury Biomarkers: A Novel Method for Quantification of the Impact on the Brain After Tumor Surgery
Circulating Brain Injury Biomarkers: A Novel Method for Quantification of the Impact on the Brain After Tumor Surgery Open
BACKGROUND: Clinical methods to quantify brain injury related to neurosurgery are scarce. Circulating brain injury biomarkers have recently gained increased interest as new ultrasensitive measurement techniques have enabled quantification …
View article: Prestroke physical activity is associated with admission haematoma volume and the clinical outcome of intracerebral haemorrhage
Prestroke physical activity is associated with admission haematoma volume and the clinical outcome of intracerebral haemorrhage Open
Background Prestroke physical activity (PA) has been linked to improved outcomes after intracerebral haemorrhage (ICH), but its association with ICH volume is unknown. We aimed to investigate associations of prestroke PA with location-spec…
View article: Overview and recent advances in incidental meningioma
Overview and recent advances in incidental meningioma Open
Overdiagnosis and excessive follow-up are potential pitfalls in the management of incidental meningioma. An MRI after 6-12 months could be reasonable to rule out rapid growth and differential diagnoses. Using the available prognostic model…
View article: Circulating Brain-Injury Markers After Surgery for Craniosynostosis
Circulating Brain-Injury Markers After Surgery for Craniosynostosis Open
These represent the first results showing significantly increased plasma levels of brain-injury biomarkers after surgery for craniosynostosis. Furthermore, we found that more extensive cranial vault procedures resulted in higher levels of …
View article: Genome-wide DNA Methylation Differences in Nonfunctioning Pituitary Adenomas With and Without Postsurgical Progression
Genome-wide DNA Methylation Differences in Nonfunctioning Pituitary Adenomas With and Without Postsurgical Progression Open
Context Tumor progression in surgically treated patients with nonfunctioning pituitary adenomas (NFPAs) is associated with excess mortality. Reliable biomarkers allowing early identification of tumor progression are missing. Objective To e…
View article: Supplement to Genome-wide DNA Methylation Differences in Non-functioning Pituitary Adenomas With and Without Postsurgical Progression
Supplement to Genome-wide DNA Methylation Differences in Non-functioning Pituitary Adenomas With and Without Postsurgical Progression Open
The main study has investigated methylation patterns in non-functioning pituitary adenoma patients. Cases included patients requiring reintervention due to progression and controls who had a post-operative residual tumor without tumor prog…
View article: Headache Before and After Endoscopic Transsphenoidal Pituitary Tumor Surgery: A Prospective Study
Headache Before and After Endoscopic Transsphenoidal Pituitary Tumor Surgery: A Prospective Study Open
Objective Headache is a common symptom among patients with pituitary tumors, as it is in the general population. The aim of the study was to investigate headache as a symptom in patients with pituitary tumors before and 6 months after endo…
View article: Circulating brain injury biomarkers increase after endoscopic surgery for pituitary tumors
Circulating brain injury biomarkers increase after endoscopic surgery for pituitary tumors Open
Pituitary tumors and subsequent treatment with endoscopic transsphenoidal surgery (ETSS) may cause injury to suprasellar structures, causing long-term fatigue and neurocognitive impairment. A method to quantify brain injury after ETSS is n…
View article: Genome-Wide DNA Methylation Differences in Patients With Non-Functioning Pituitary Adenomas With or Without Postsurgical Intervention
Genome-Wide DNA Methylation Differences in Patients With Non-Functioning Pituitary Adenomas With or Without Postsurgical Intervention Open
Background: More than half of all surgically treated patients with non-functioning pituitary adenomas (NFPA) experience tumor progression during their follow-up, with some of these adenomas exhibiting locally aggressive behavior. Tumor pro…
View article: Impact of meningioma surgery on use of antiepileptic, antidepressant, and sedative drugs: A Swedish nationwide matched cohort study
Impact of meningioma surgery on use of antiepileptic, antidepressant, and sedative drugs: A Swedish nationwide matched cohort study Open
Background Meningioma is the most common primary intracranial tumor and surgery is the main treatment modality. As death from lack of tumor control is rare, other outcome measures like anxiety, depression and post‐operative epilepsy are be…
View article: Sinonasal Symptoms and Self-Reported Health before and after Endoscopic Pituitary Surgery—A Prospective Study
Sinonasal Symptoms and Self-Reported Health before and after Endoscopic Pituitary Surgery—A Prospective Study Open
Objectives Despite the limited invasiveness of endoscopic transsphenoidal surgery (ETSS), some degree of nasal structure destruction is unavoidable. Our objective was to evaluate sinonasal morbidity and self-reported health before and 6 mo…