Thomas Snavely
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View article: Target‐based discovery of antagonists of the tick (<scp><i>Rhipicephalus microplus</i></scp>) kinin receptor identifies small molecules that inhibit midgut contractions
Target‐based discovery of antagonists of the tick (<span><i>Rhipicephalus microplus</i></span>) kinin receptor identifies small molecules that inhibit midgut contractions Open
BACKGROUND A GPCR (G protein‐coupled receptor) target‐based approach was applied to identify antagonists of the arthropod‐specific tick kinin receptor. These small molecules were expected to reproduce the detrimental phenotypic effects tha…
View article: Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice Open
Elesclomol rescues Menkes disease mice Menkes disease results from loss-of-function mutations in the P-type copper-transporting adenosine triphosphatase ATP7A. Children diagnosed with Menkes present with connective tissue abnormalities and…
View article: Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of <i>Mycobacterium tuberculosis</i> Adenosine Kinase
Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of <i>Mycobacterium tuberculosis</i> Adenosine Kinase Open
Mycobacterium tuberculosis adenosine kinase (MtbAdoK) is an essential enzyme of Mtb and forms part of the purine salvage pathway within mycobacteria. Evidence suggests that the purine salvage pathway might play a crucial role in Mtb surviv…
View article: Wide-ranging and unexpected consequences of altered Pol II catalytic activity <i>in vivo</i>
Wide-ranging and unexpected consequences of altered Pol II catalytic activity <i>in vivo</i> Open
Here we employ a set of RNA Polymerase II (Pol II) activity mutants to determine the consequences of increased or decreased Pol II catalysis on gene expression in Saccharomyces cerevisiae. We find that alteration of Pol II catalytic rate, …
View article: Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo
Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo Open
Here we employ a set of RNA Polymerase II (Pol II) activity mutants to determine the consequences of increased or decreased Pol II catalysis on gene expression in Saccharomyces cerevisiae. We find that alteration of Pol II catalytic rate, …