Thomas P. J. Solomon
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View article: Wound healing and angiogenic profiling of dermal endothelial cells isolated from people with type 2 diabetes
Wound healing and angiogenic profiling of dermal endothelial cells isolated from people with type 2 diabetes Open
Impaired wound healing in type 2 diabetes (T2D) is associated with microvascular dysfunction and remains a significant clinical challenge. We aimed to determine whether primary human dermal microvascular endothelial cells (HDMVECs) from in…
View article: The sports nutrition knowledge of large language model (LLM) artificial intelligence (AI) chatbots: An assessment of accuracy, completeness, clarity, quality of evidence, and test-retest reliability
The sports nutrition knowledge of large language model (LLM) artificial intelligence (AI) chatbots: An assessment of accuracy, completeness, clarity, quality of evidence, and test-retest reliability Open
Background Generative artificial intelligence (AI) chatbots are increasingly utilised in various domains, including sports nutrition. Despite their growing popularity, there is limited evidence on the accuracy, completeness, clarity, evide…
View article: The effect of post-exercise heat exposure (passive heat acclimation) on endurance exercise performance: a systematic review and meta-analysis
The effect of post-exercise heat exposure (passive heat acclimation) on endurance exercise performance: a systematic review and meta-analysis Open
Open Science Foundation ( https://doi.org/10.17605/OSF.IO/256XZ ).
View article: Effects of caloric restriction with different doses of exercise on fat loss in people living with type 2 diabetes: A secondary analysis of the DOSE-EX randomized clinical trial
Effects of caloric restriction with different doses of exercise on fat loss in people living with type 2 diabetes: A secondary analysis of the DOSE-EX randomized clinical trial Open
All interventions were superior in reducing FM% compared to standard care. Adding exercise to a caloric restriction was superior in reducing FM% compared to a caloric restriction alone.
View article: effect of post-exercise heat exposure (passive heat acclimation) on endurance exercise performance
effect of post-exercise heat exposure (passive heat acclimation) on endurance exercise performance Open
"Active" heat acclimation (exercise-in-the-heat) can improve exercise performance in the heat. An alternative strategy is "passive" heat acclimation using post-exercise heat exposure, but its efficacy is unclear.
View article: Extremely uncommon torsion and communicating ruptured rudimentary horn pregnancy at third trimester: A case report
Extremely uncommon torsion and communicating ruptured rudimentary horn pregnancy at third trimester: A case report Open
Torsion and rupture are life-threatening emergencies in rudimentary horn pregnancy, an extremely rare type of ectopic pregnancy. This case report aims to share the diagnosis and treatment of a patient, with torsion and ruptured horn pregna…
View article: Exercise-induced changes to the fiber type-specific redox state in human skeletal muscle are associated with aerobic capacity
Exercise-induced changes to the fiber type-specific redox state in human skeletal muscle are associated with aerobic capacity Open
This study is the first to use autofluorescent imaging to describe differential redox states within human skeletal muscle fiber types with exercise. Our findings highlight an easy and efficacious technique for assessing skeletal muscle red…
View article: Adding Different Exercise Training Volumes to a Diet-Induced Weight Loss Facilitates Fat Loss and Maintains Fat-Free Mass in a Dose-Depending Fashion in Persons with Newly Diagnosed Type 2 Diabetes: Secondary Findings from the DOSE-EX Multi-Arm, Parallel-Group, Randomized Trial
Adding Different Exercise Training Volumes to a Diet-Induced Weight Loss Facilitates Fat Loss and Maintains Fat-Free Mass in a Dose-Depending Fashion in Persons with Newly Diagnosed Type 2 Diabetes: Secondary Findings from the DOSE-EX Multi-Arm, Parallel-Group, Randomized Trial Open
OBJECTIVE To assess the dose-response effects of exercise in combination with a diet-induced weight loss on fat mass (FM) percentage (FM%) in persons with diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS In this secondary analysis of…
View article: Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial
Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial Open
Diet-induced weight loss is associated with improved beta-cell function in people with type 2 diabetes (T2D) with remaining secretory capacity. It is unknown if adding exercise to diet-induced weight loss improves beta-cell function and if…
View article: The Effect of Adding Different Doses of Exercise Training to a Diet-Induced Weight Loss on Beta-Cell Function in Persons with Newly Diagnosed Type 2 Diabetes: Primary Findings from the DOSE-EX Multi-Arm, Parallel-Group, Randomized Trial
The Effect of Adding Different Doses of Exercise Training to a Diet-Induced Weight Loss on Beta-Cell Function in Persons with Newly Diagnosed Type 2 Diabetes: Primary Findings from the DOSE-EX Multi-Arm, Parallel-Group, Randomized Trial Open
Diet-induced weight loss improves beta-cell function in persons with type 2 diabetes (T2D) with remaining secretory capacity. It is unknown if adding exercise to a diet-induced weight loss improves beta-cell function and if exercise volume…
View article: Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans
Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans Open
Background Fibroblast growth factor 21 (FGF21) treatment improves metabolic homeostasis in diverse species, including humans. Physiologically, plasma FGF21 levels increase modestly after glucose ingestion, but it is unclear whether this is…
View article: Editorial: Understanding the Heterogeneity in Exercise-Induced Changes in Glucose Metabolism to Help Optimize Treatment Outcomes
Editorial: Understanding the Heterogeneity in Exercise-Induced Changes in Glucose Metabolism to Help Optimize Treatment Outcomes Open
EDITORIAL article Front. Endocrinol., 27 May 2021Sec. Clinical Diabetes https://doi.org/10.3389/fendo.2021.699354
View article: Additional file 4 of The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the “DOSE-EX” multi-arm parallel-group randomised clinical trial
Additional file 4 of The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the “DOSE-EX” multi-arm parallel-group randomised clinical trial Open
Additional file 4. Hyperglycaemic Clamp Blood Sampling Schedule.
View article: Exercise-Induced Improvements in Postprandial Glucose Response Are Blunted by Pre-Exercise Hyperglycemia: A Randomized Crossover Trial in Healthy Individuals
Exercise-Induced Improvements in Postprandial Glucose Response Are Blunted by Pre-Exercise Hyperglycemia: A Randomized Crossover Trial in Healthy Individuals Open
ClinicalTrials.gov, identifier NCT03284216.
View article: Beta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism
Beta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism Open
(i) BAIBA is released from skeletal muscle at rest and during exercise under healthy conditions but is suppressed during exercise following leg immobilization, (ii) plasma BAIBA concentrations inversely associate with insulin secretory fun…
View article: The benefits of physical exercise for the health of the pancreatic β‐cell: a review of the evidence
The benefits of physical exercise for the health of the pancreatic β‐cell: a review of the evidence Open
New Findings What is the topic of this review? This review discusses the evidence of the benefits of exercise training for β‐cell health through improvements in function, proliferation and survival which may have implications in the treatm…
View article: Is National Resident Matching Program Rank Predictive of Resident Performance or Post-graduation Achievement? 10 Years at One Emergency Medicine Residency
Is National Resident Matching Program Rank Predictive of Resident Performance or Post-graduation Achievement? 10 Years at One Emergency Medicine Residency Open
We found that the position on our NRMP rank list was of little value in predicting which residents would do best in residency or take on academic or leadership roles once graduated. Residencies should evaluate the processes they use to gen…
View article: Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans
Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans Open
The purpose of this investigation was to evaluate the effects of experimental hyperglycemia on oxidative damage (OX), advanced glycation end products (AGEs), and the receptor for AGEs (RAGE) through an in vivo approach. Obese subjects (n =…
View article: Skeletal muscle Nur77 and NOR1 insulin responsiveness is blunted in obesity and type 2 diabetes but improved after exercise training
Skeletal muscle Nur77 and NOR1 insulin responsiveness is blunted in obesity and type 2 diabetes but improved after exercise training Open
Obesity and type 2 diabetes (T2DM) are characterized by a blunted metabolic response to insulin, and strongly manifests in skeletal muscle insulin resistance. The orphan nuclear receptors, Nur77 and NOR1, regulate insulin-stimulated nutrie…
View article: Targeting Postprandial Hyperglycemia With Physical Activity May Reduce Cardiovascular Disease Risk. But What Should We Do, and When Is the Right Time to Move?
Targeting Postprandial Hyperglycemia With Physical Activity May Reduce Cardiovascular Disease Risk. But What Should We Do, and When Is the Right Time to Move? Open
Physical inactivity and excessive postprandial hyperglycemia are two major independent risk factors for type 2 diabetes and cardiovascular-related mortality. Current health policy guidelines recommend at least 150 min of physical activity …
View article: Sources of Inter-individual Variability in the Therapeutic Response of Blood Glucose Control to Exercise in Type 2 Diabetes: Going Beyond Exercise Dose
Sources of Inter-individual Variability in the Therapeutic Response of Blood Glucose Control to Exercise in Type 2 Diabetes: Going Beyond Exercise Dose Open
In the context of type 2 diabetes, inter-individual variability in the therapeutic response of blood glucose control to exercise exists to the extent that some individuals, occasionally referred to as "non-responders," may not experience t…
View article: Probing the Effect of Physiological Concentrations of IL-6 on Insulin Secretion by INS-1 832/3 Insulinoma Cells under Diabetic-Like Conditions
Probing the Effect of Physiological Concentrations of IL-6 on Insulin Secretion by INS-1 832/3 Insulinoma Cells under Diabetic-Like Conditions Open
Exercise improves insulin secretion by pancreatic beta cells (β-cells) in patients with type 2 diabetes, but molecular mechanisms of this effect are yet to be determined. Given that contracting skeletal muscle causes a spike in circulating…
View article: Pro-inflammatory cytokines attenuate glucose-stimulated insulin secretion from INS-1E insulinoma cells by restricting mitochondrial pyruvate oxidation capacity – Novel mechanistic insight from real-time analysis of oxidative phosphorylation
Pro-inflammatory cytokines attenuate glucose-stimulated insulin secretion from INS-1E insulinoma cells by restricting mitochondrial pyruvate oxidation capacity – Novel mechanistic insight from real-time analysis of oxidative phosphorylation Open
Pro-inflammatory cytokines cause pancreatic beta cell failure during the development of type 2 diabetes. This beta cell failure associates with mitochondrial dysfunction, but the precise effects of cytokines on mitochondrial respiration re…
View article: Do skeletal muscle-secreted factors influence the function of pancreatic β-cells?
Do skeletal muscle-secreted factors influence the function of pancreatic β-cells? Open
Skeletal muscle is an endocrine organ that secretes a variety of compounds including proteins (myokines), metabolites, microRNAs (miRNAs), and exosomes, many of which are regulated by exercise and play important roles in endocrine signalin…