Thomas Spruce
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View article: The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians Open
Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a striking process of evolutionary s…
View article: The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians Open
The eutherian placenta is a major site for parental genetic conflict. Here, we identify the X-linked Mbnl3 gene as a novel player in this dispute. Mbnl3 belongs to an RNA binding protein family whose members regulate alternative splicing a…
View article: The role of maternal pioneer factors in predefining first zygotic responses to inductive signals
The role of maternal pioneer factors in predefining first zygotic responses to inductive signals Open
Embryonic development yields many different cell types in response to just a few families of inductive signals. The property of a signal-receiving cell that determines how it responds to such signals, including the activation of cell type-…
View article: Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus
Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus Open
Antisense morpholino oligomers (MOs) have been indispensable tools for developmental biologists to transiently knock down (KD) genes rather than to knock them out (KO). Here we report on the implications of genetic KO versus MO-mediated KD…