Thomas S. Jacques
YOU?
Author Swipe
View article: Life after pediatric low-grade glioma: the utility of survivor narratives in pediatric low-grade glioma outcome research
Life after pediatric low-grade glioma: the utility of survivor narratives in pediatric low-grade glioma outcome research Open
Background Pediatric low-grade glioma (PLGG) is a generally survivable Pediatric CNS tumor, though enduring functional and quality of life (QOL) impairments often occur. To date, PLGG outcome research has relied on quantitative scales, suc…
View article: PAEDIATRIC LOW-GRADE GLIOMA (PLGG): UNDER THE KNIFE FOR A BETTER QUALITY OF LIFE. EVALUATION & PROGNOSTICATION OF LONG-TERM PLGG SURVIVOR FUNCTIONAL AND QUALITY OF LIFE OUTCOMES
PAEDIATRIC LOW-GRADE GLIOMA (PLGG): UNDER THE KNIFE FOR A BETTER QUALITY OF LIFE. EVALUATION & PROGNOSTICATION OF LONG-TERM PLGG SURVIVOR FUNCTIONAL AND QUALITY OF LIFE OUTCOMES Open
AIMS PLGG is a generally survivable Paediatric CNS tumour. Previous research demonstrates an advantageous prog- nostic relationship between receipt & degree of surgical resection with OS and PFS, but there has been no large- cohort evaluat…
View article: Supplementary Figure S5 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S5 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 5 Features of the GBM_CBM and GBM_MES_ATYP subgroups
View article: Supplementary Figure S6 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S6 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 6 Multivariate analyses within the TYA cohort.
View article: Supplementary Table S2 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Table S2 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary Table 2 Copy number analysis. Gene amplifications derived from methylation array analysis for the TYA cohort with associated frequencies.
View article: Supplementary Table S4 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Table S4 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary Table 4 Sequencing data analysis. Mutations in Cancer Census Genes identified in TYA HGG cases from available whole exome sequencing data (n=107).
View article: Supplementary Figure S4 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S4 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 4 Mutations in TYA gliomas
View article: Supplementary Figure S2 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S2 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 2 DNA Methylation profiling of the TYA HGG cohort.
View article: Supplementary Table S3 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Table S3 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary Table 3 Copy number analysis. Gene deletions derived from methylation array analysis for the TYA cohort with associated frequencies.
View article: Supplementary Figure S1 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S1 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 1 A, Bar plot showing the frequency of age distribution across the TYA cohort, and the gender proportions. Blue representing male, pink representing female. B, Pie chart representing the original diagnoses of the TYA c…
View article: Supplementary Figure S3 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S3 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 3 DNA copy number profiling of the TYA cohort.
View article: Supplementary Table S1 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Table S1 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary Table 1 Sample cohort. Clinicopathological and molecular profiling data of the TYA HGG cohort (n=207).
View article: Data from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Data from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Purpose:High-grade gliomas (HGG) occur in any central nervous system location and at any age. HGGs in teenagers/young adults (TYA) are understudied. This project aimed to characterize these tumors to support accurate stratification of pati…
View article: Pediatric-Type Diffuse Low-Grade Gliomas with <i>MYB</i> Alterations: Neuroimaging of the Diffuse Astrocytomas, <i>MYB-</i> or <i>MYBL1</i> -Altered
Pediatric-Type Diffuse Low-Grade Gliomas with <i>MYB</i> Alterations: Neuroimaging of the Diffuse Astrocytomas, <i>MYB-</i> or <i>MYBL1</i> -Altered Open
Imaging features of DA-MYB in children are variable, and the fireworks sign was identified only in a subset of patients. It was usually present in patients with large hemispheric tumors but was also observed in brainstem lesions. Diffusion…
View article: Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification Open
DNA methylation-based classification is integral to contemporary neuro-oncological diagnostics, as highlighted by the current World Health Organization (WHO) classification of central nervous system (CNS) tumors. We introduce the Heidelber…
View article: Safety and Diagnostic Utility of Brain Biopsy and Metagenomics in Decision-Making for Patients with Inborn Errors of Immunity (IEI) and Unexplained Neurological Manifestations
Safety and Diagnostic Utility of Brain Biopsy and Metagenomics in Decision-Making for Patients with Inborn Errors of Immunity (IEI) and Unexplained Neurological Manifestations Open
Unexplained neurological symptoms can pose a diagnostic challenge in patients with inborn errors of immunity (IEI) where the aetiology can be varied, and diverse pathologies may require contrasting treatments. Brain biopsy, the process of …
View article: Supplementary Figure S6 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Figure S6 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
Cohort-wide oncoplot for tissue vs cfDNA variants.
View article: Supplementary Figure S9 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Figure S9 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
STRINGDB interaction networks of disease-specific fragmentomics clusters.
View article: Supplementary Table 7 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Table 7 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
Paediatric cancer specific targeted panel.
View article: Supplementary Table 9 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Table 9 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
Paediatric cancer specific cfDNA panel (ctPC Panel).
View article: Supplementary Figure S10 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Figure S10 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
Similarity matrix for TFBS sets.
View article: Supplementary Figure S4 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Figure S4 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
Top relapse-specific copy number events.
View article: Supplementary Table 2 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Table 2 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
Relapse vs. primary somatic variants.
View article: Supplementary Table 8 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Table 8 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
RMH solid tumour panel.
View article: Supplementary Figure S2 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Figure S2 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
Disease-specific diagnostic vs. relapse sequence variants.
View article: Supplementary Figure S12 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Figure S12 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
Fragmentomics reveals disease specific differential accessibility at transcription factor binding sites.
View article: Supplementary Table 11 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Table 11 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
Samples used for lcWGS.
View article: Supplementary Figure S8 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Figure S8 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
Concordance between ctDNA and tissue copy number profiles.
View article: Supplementary Table 4 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
Supplementary Table 4 from Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States Open
Relapse Vs. primary copy number variants.