Thomas Steffen
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The rate of complicated appendicitis during a nonpharmaceutical intervention in two territories with different COVID-19 incidence Open
A higher rate of complicated appendicitis was found in the region most affected by the COVID-19 pandemic. NPIs in a pandemic situation, such as a lockdown period or restricted access to health services, leads to higher morbidity in patient…
View article: Concordance of ChatGPT artificial intelligence decision-making in colorectal cancer multidisciplinary meetings: retrospective study
Concordance of ChatGPT artificial intelligence decision-making in colorectal cancer multidisciplinary meetings: retrospective study Open
Background The objective of this study was to evaluate the concordance between therapeutic recommendations proposed by a multidisciplinary team meeting and those generated by a large language model (ChatGPT) for colorectal cancer. Although…
View article: ChatGPT for Therapy Conception of Colorectal Cancer: Can Artificial Intelligence Complement a Traditional Tumor Board?
ChatGPT for Therapy Conception of Colorectal Cancer: Can Artificial Intelligence Complement a Traditional Tumor Board? Open
Background Although multidisciplinary tumor boards (MDT) represent the gold standard for decision-making in cancer treatment, they require significant resources and may be susceptible to human bias. Artificial intelligence (AI), particular…
View article: A comprehensive narrative review on paradigm shift in the treatment of esophageal and rectal cancer
A comprehensive narrative review on paradigm shift in the treatment of esophageal and rectal cancer Open
The incidence of esophageal and rectal cancer is rising globally. The combination of neoadjuvant chemoradiotherapy (nCRT) with watchful waiting (W&W) strategies has been shown to be an effective approach for maintaining a high quality of l…
View article: Giant Duodenal Brunneroma: Report of a Rare Case and Review of the Literature
Giant Duodenal Brunneroma: Report of a Rare Case and Review of the Literature Open
BACKGROUND Brunneromas are among the rarest benign tumors of the upper gastrointestinal tract. They arise from the Brunner's glands and patients have a good prognosis if treated timely and radically. Because symptoms are rare, their diagno…
Intraoperative Allogeneic Blood Transfusion Has No Impact on Postoperative Short-Term Outcomes After Pancreatoduodenectomy for Periampullary Malignancies: A Propensity Score Matching Analysis and Mediation Analysis Open
Background/Objectives: The aim of this study was to investigate the association between intraoperative blood transfusion (BT) and the short-term outcomes of pancreatoduodenectomy (PD) for patients with periampullary malignancies. Methods: …
Late marginal ulcer perforation after Roux-en-Y Gastric bypass – A case report with two-step management Open
A two-step procedure with discontinuity resection for damage control surgery, patient stabilisation, and improvement of nutritional status, followed by elective continuity restoration with a new gastrojejunostomy, is considered feasible in…
Quality of Surgical Outcome Reporting in Randomised Clinical Trials of Multimodal Rectal Cancer Treatment: A Systematic Review Open
Introduction: Randomised controlled trials (RCTs) continue to provide the best evidence for treatment options, but the quality of reporting in RCTs and the completeness rate of reporting of surgical outcomes and complication data vary wide…
Systematic review on groove pancreatitis: management of a rare disease Open
Background Groove pancreatitis is a focal form of chronic pancreatitis affecting the area of the paraduodenal groove. The aim of this systematic review was to assess the clinical presentation, diagnosis and treatment of patients with groov…
View article: Immediate stabilization of pedicle screws
Immediate stabilization of pedicle screws Open
This study was designed as proof of principle and safety test of the novel technique, the Immediate Stabilization System (ISS). The technique is designed to immediately stabilize polymer-augmented pedicle screws (PAS) in deficient bone and…
Current Research and Development in Hyperthermic Intraperitoneal Chemotherapy (HIPEC)—A Cross-Sectional Analysis of Clinical Trials Registered on ClinicalTrials.gov Open
Introduction: Over the past two decades, cytoreductive surgery and HIPEC has improved outcomes for selected patients with peritoneal metastasis from various origins. This is a cross-sectional study with descriptive analyses of HIPEC trials…
Computationally efficient infinite-horizon indefinite model predictive control with disturbance preview information Open
This paper proposes a model predictive control (MPC) scheme for maximising the benefit of a useful disturbance by exploiting preview information of the disturbance, in the context of goal-oriented operation. For a constrained system, subje…
View article: Comprehensive Treatment Algorithms of the Swiss Peritoneal Cancer Group for Peritoneal Cancer of Gastrointestinal Origin
Comprehensive Treatment Algorithms of the Swiss Peritoneal Cancer Group for Peritoneal Cancer of Gastrointestinal Origin Open
Peritoneal cancer (PC) is a dire finding, yet in selected patients, long-term survival is possible. Complete cytoreductive surgery (CRS) together with combination immunochemotherapy is essential to achieve cure. Hyperthermic intraperitonea…
A review of component-in-the-loop: Cyber-physical experiments for rapid system development and integration Open
To meet rising demands in performance and emissions compliance, companies are driven to develop systems of ever-increasing complexity. In-the-loop methods use a hybrid approach combining a physical subsystem with a virtual subsystem in rea…
Intraoperative indocyanine green-visualization in a difficult to localize central cholangiocarcinoma – A case report Open
This case report supports the very promising intraoperative use of fluorescence imaging for the localization of superficial hepatic tumours. Timing and correct administration of ICG is important.
Portal vein thrombosis in COVID-19 infection Open
Background The COVID-19 pandemic has rapidly spread worldwide. As it is a novel disease, we have less experience in its possible appearances. Predominantly affecting the respiratory tract, about 20–43% patients also present with extrapulmo…
Investigating Commercial Filaments for 3D Printing of Stiff and Elastic Constructs with Ligament-Like Mechanics Open
The current gold standard technique for treatment of anterior cruciate ligament (ACL) injury is reconstruction with autograft. These treatments have a relatively high failure and re-tear rate. To overcome this, tissue engineering and addit…
Decision-Making Analysis for Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer: A Survey by the Executive Committee of the Peritoneal Surface Oncology Group International (PSOGI) Open
Objectives: To assess the individual treatment strategies among international experts in peritoneal carcinosis, specifically their decision-making in the process of patient selection for hyperthermic intraperitoneal chemotherapy (HIPEC) in…
Fatigue Testing of a Titanium Tapered Rod versus Two Rods Connected by a Parallel Connector across the Cervicothoracic Junction: A Biomechanical Study Open
This study compares the fatigue failure of a tapered titanium-rod construct against two connected titanium rods (domino construct) across the cervicothoracic junction. All testing was carried out in a simulated flexion-extension plane. The…
Indeterminate dendritic cell tumor in the pancreas Open
Indeterminate dendritic cell tumor (IDCT) is an extremely rare hematologic neoplastic disorder with proliferation of indeterminate dendritic cells. In the vast majority of cases, IDCTs are restricted to the skin or lymph nodes. To our know…
A rare case of ileocolic intussusception due to severe endometriosis Open
Intestinal intussusception is a rare cause of intestinal obstruction; intestinal intussusception associated with endometriosis is very rare. The varied clinical presentations make the diagnosis demanding. In this article, we report the cas…
Physically stimulated nanotheranostics for next generation cancer therapy: Focus on magnetic and light stimulations Open
Physically or externally stimulated nanostructures often employ multimodality and show encouraging results at preclinical stage in cancer therapy. Specially designed smart nanostructures such as hybrid nanostructures are responsive to exte…
Feasibility of the annulus fibrosus repair with in situ gelating hydrogels – A biomechanical study Open
The surgical standard of care for lumbar discectomy leaves the annulus fibrosus (AF) defect unrepaired, despite considerable risk for a recurrent herniation. Identification of a viable defect repair strategy has until now been elusive. The…
Thermoreversible hyaluronan-hydrogel and autologous nucleus pulposus cell delivery regenerates human intervertebral discs in an ex vivo, physiological organ culture model Open
Numerous studies show promise for cell-based tissue engineering strategies aiming to repair painful intervertebral disc (IVD) degeneration. However, clinical translation to human IVD repair is slow. In the present study, the regenerative p…
View article: Mutations of RAS/RAF Proto-oncogenes Impair Survival After Cytoreductive Surgery and HIPEC for Peritoneal Metastasis of Colorectal Origin
Mutations of RAS/RAF Proto-oncogenes Impair Survival After Cytoreductive Surgery and HIPEC for Peritoneal Metastasis of Colorectal Origin Open
Background: Adequate selection of patients with peritoneal metastasis (PM) for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) remains critical for successful long-term outcomes. Factors reflecting tumor b…