Thomas Steinkellner
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View article: Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration
Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration Open
Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2 + DA neurons of the substantia nigra pars compacta (SNc) …
View article: Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses
Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses Open
The ventral tegmental area (VTA) contains projection neurons that release the neurotransmitters dopamine, GABA, and/or glutamate from distal synapses. VTA also contains GABA neurons that synapse locally on to dopamine neurons, synapses wid…
View article: Evidence for low affinity of GABA at the vesicular monoamine transporter VMAT2 – Implications for transmitter co-release from dopamine neurons
Evidence for low affinity of GABA at the vesicular monoamine transporter VMAT2 – Implications for transmitter co-release from dopamine neurons Open
Midbrain dopamine (DA) neurons comprise a heterogeneous population of cells. For instance, some DA neurons express the vesicular glutamate transporter VGLUT2 allowing these cells to co-release DA and glutamate. Additionally, GABA may be co…
View article: Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses
Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses Open
The ventral tegmental area (VTA) contains projection neurons that release the neurotransmitters dopamine, GABA, and/or glutamate from distal synapses. VTA also contains GABA neurons that synapse locally on to dopamine neurons, synapses wid…
View article: Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration
Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration Open
Loss of select neuronal populations such as midbrain dopamine (DA) neurons is a pathological hallmark of Parkinson's disease (PD). The small neuronal protein α-synuclein has been related both genetically and neuropathologically to PD, yet …
View article: Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses
Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses Open
The ventral tegmental area (VTA) contains projection neurons that release the neurotransmitters dopamine, GABA, and/or glutamate from distal synapses. VTA also contains GABA neurons that synapse locally on to VTA dopamine neurons, synapses…
View article: Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses
Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses Open
The ventral tegmental area (VTA) contains projection neurons that release the neurotransmitters dopamine, GABA, and/or glutamate from distal synapses. VTA also contains GABA neurons that synapse locally on to dopamine neurons, synapses wid…
View article: Evidence for low affinity of GABA at the vesicular monoamine transporter VMAT2 – implications for transmitter co-release from dopamine neurons
Evidence for low affinity of GABA at the vesicular monoamine transporter VMAT2 – implications for transmitter co-release from dopamine neurons Open
Background and Purpose Midbrain dopamine (DA) neurons comprise a heterogeneous population of cells. For instance, some DA neurons express the vesicular glutamate transporter VGLUT2 allowing these cells to co-release DA and glutamate. Addit…
View article: Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses
Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses Open
The ventral tegmental area (VTA) contains projection neurons that release the neurotransmitters dopamine, GABA, and/or glutamate from distal synapses. VTA also contains GABA neurons that synapse locally on to dopamine neurons, synapses wid…
View article: Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration
Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration Open
Loss of select neuronal populations such as midbrain dopamine (DA) neurons is a pathological hallmark of Parkinson’s disease (PD). The small neuronal protein α-synuclein has been related both genetically and neuropathologically to PD, yet …
View article: Photo-Oxidation of MiniSOG Related to Cultured Neurons v1
Photo-Oxidation of MiniSOG Related to Cultured Neurons v1 Open
This is a general protocol is for photo-oxidizing neuro-vesicle proteins with MiniSOG. We developed a genetically encoded probe to identify glutamatergic synaptic vesicles at the levels of both light and electron microscopy (EM) by fusing …
View article: Dopamine neurons exhibit emergent glutamatergic identity in Parkinson’s disease
Dopamine neurons exhibit emergent glutamatergic identity in Parkinson’s disease Open
Loss of midbrain dopamine neurons causes the cardinal symptoms of Parkinson’s disease. However, not all dopamine neurons are equally vulnerable and a better understanding of the cell-type specific properties relating to selective dopamine …
View article: Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration
Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration Open
Cholinergic projections from the medial habenula (MHb) to the interpeduncular nucleus (IPN) have been studied for their complex contributions to nicotine addiction and have been implicated in nicotine reinforcement, aversion, and withdrawa…
View article: Constitutive Endocytosis of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter-3 Requires ARFGAP1
Constitutive Endocytosis of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter-3 Requires ARFGAP1 Open
The eukaryotic endocytic pathway regulates protein levels available at the plasma membrane by recycling them into specific endosomal compartments. ARFGAP1 is a component of the coat protein I (COPI) complex but it also plays a role in prom…
View article: Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age‐related neurodegeneration
Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age‐related neurodegeneration Open
Age is the greatest risk factor for Parkinson's disease (PD) which causes progressive loss of dopamine (DA) neurons, with males at greater risk than females. Intriguingly, some DA neurons are more resilient to degeneration than others. Inc…
View article: Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure
Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure Open
Psychiatric disease often produces symptoms that have divergent effects on neural activity. For example, in drug dependence, dysfunctional value-based decision-making and compulsive-like actions have been linked to hypo- and hyperactivity …
View article: Author response: Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure
Author response: Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Psychiatric disease often produces symptom…
View article: Genetic Probe for Visualizing Glutamatergic Synapses and Vesicles by 3D Electron Microscopy
Genetic Probe for Visualizing Glutamatergic Synapses and Vesicles by 3D Electron Microscopy Open
Communication between neurons relies on the release of diverse neurotransmitters, which represent a key-defining feature of a neuron's chemical and functional identity. Neurotransmitters are packaged into vesicles by specific vesicular tra…
View article: Mechanism for differential recruitment of orbitostriatal transmission during outcomes and actions in alcohol dependence
Mechanism for differential recruitment of orbitostriatal transmission during outcomes and actions in alcohol dependence Open
Psychiatric disease often produces symptoms that have divergent effects on neural activity. For example, in drug dependence, dysfunctional value-based decision-making and compulsive-like actions have been linked to hypo- and hyper-activity…
View article: VGLUT modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration
VGLUT modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration Open
Age is the greatest risk factor for Parkinson’s disease (PD) which causes progressive loss of dopamine (DA) neurons, with males at greater risk than females. We found that vesicular glutamate transporter (VGLUT) expression mediates vulnera…
View article: A genetic probe for visualizing glutamatergic synapses and vesicles by 3D electron microscopy
A genetic probe for visualizing glutamatergic synapses and vesicles by 3D electron microscopy Open
Communication between neurons relies on the release of diverse neurotransmitters, which represent a key-defining feature of a neuron’s chemical and functional identity. Neurotransmitters are packaged into vesicles by specific vesicular tra…
View article: Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala
Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala Open
Alcohol dependence induces hypersensitivity of the SP/NK-1R system and its regulation of CeA inhibitory transmission.
View article: Differential Expression of VGLUT2 in Mouse Mesopontine Cholinergic Neurons
Differential Expression of VGLUT2 in Mouse Mesopontine Cholinergic Neurons Open
Vesicular glutamate transporters (VGLUTs) mediate the synaptic uptake of glutamate from the cytosol into synaptic vesicles and are considered unambiguous neurochemical markers of glutamate neurons. However, many neurons not classically tho…
View article: Distinct contribution of axonal and somatodendritic serotonin transporters in drosophila olfaction
Distinct contribution of axonal and somatodendritic serotonin transporters in drosophila olfaction Open
The serotonin transporter (SERT) regulates serotonergic neurotransmission by retrieving released serotonin and replenishing vesicular stores. SERT is not only delivered to axons but it is also present on the neuronal soma and on dendrites.…
View article: Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain
Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain Open
Mice lacking the epidermal growth factor receptor (EGFR) develop an early postnatal degeneration of the frontal cortex and olfactory bulbs and show increased cortical astrocyte apoptosis. The poor health and early lethality of EGFR −/− mic…
View article: Flotillin‐1 interacts with the serotonin transporter and modulates chronic corticosterone response
Flotillin‐1 interacts with the serotonin transporter and modulates chronic corticosterone response Open
Aberrant serotonergic neurotransmission in the brain is considered at the core of the pathophysiological mechanisms involved in neuropsychiatric disorders. Gene by environment interactions contribute to the development of depression and in…