Thomas Stimpfl
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View article: Preoperative Pregabalin and the Cp50 for Skin Incision During Target-Controlled Propofol Infusion: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial
Preoperative Pregabalin and the Cp50 for Skin Incision During Target-Controlled Propofol Infusion: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial Open
BACKGROUND: The potency of propofol is measured by its Cp50 value, which is the plasma concentration required to suppress a motor response in 50% of patients during surgical incisions. This Cp50 value can be affected by the concurrent use …
View article: Oral ketamine for the treatment of major depressive and bipolar disorder, a randomized controlled trial and meta-analysis
Oral ketamine for the treatment of major depressive and bipolar disorder, a randomized controlled trial and meta-analysis Open
Ketamine represents a significant advancement in antidepressant therapy, but the commonly used intravenous and intranasal application routes currently limit its availability beyond specialized centers. By contrast, oral ketamine treatment …
View article: A fast GC–MS/MS method for the simultaneous measurement of key metabolites of peroxisomal beta-oxidation and ether lipid biosynthesis in human fibroblasts
A fast GC–MS/MS method for the simultaneous measurement of key metabolites of peroxisomal beta-oxidation and ether lipid biosynthesis in human fibroblasts Open
Peroxisomes are subcellular compartments that host a variety of metabolic pathways, including the chain shortening of fatty acids (FAs) by beta-oxidation and certain steps in the formation of ether lipids. Here, we describe the development…
View article: Human in vivo assessment of ketamine binding of the serotonin transporter—follow up at a higher dose
Human in vivo assessment of ketamine binding of the serotonin transporter—follow up at a higher dose Open
Ketamine is a rapid-acting antidepressant approved in the indication of treatment-resistant depression. As its clinical use expands, identifying underlying molecular mechanisms is essential. The serotonin transporter (SERT) is well known a…
View article: A fast GC-MS/MS method for the simultaneous measurement of key metabolites of peroxisomal beta-oxidation and ether lipid biosynthesis
A fast GC-MS/MS method for the simultaneous measurement of key metabolites of peroxisomal beta-oxidation and ether lipid biosynthesis Open
Peroxisomes are subcellular compartments that host a variety of metabolic pathways, including the chain shortening of fatty acids (FAs) by beta-oxidation and certain steps in the formation of ether lipids. Here, we describe the development…
View article: Meropenem plasma concentrations in critically ill patients treated with the novel multi organ replacement therapy ADVOS
Meropenem plasma concentrations in critically ill patients treated with the novel multi organ replacement therapy ADVOS Open
Background: Optimal dosing of antibiotics in critically ill patients treated with the novel multi organ replacement therapy ADVOS (ADVanced Organ Support) based on albumin dialysis is unclear. This study aims to provide real life data on m…
View article: Cerebrospinal fluid concentrations of ceftaroline and ceftazidime/avibactam in healthy volunteers: Pharmacokinetics and probability of target attainment
Cerebrospinal fluid concentrations of ceftaroline and ceftazidime/avibactam in healthy volunteers: Pharmacokinetics and probability of target attainment Open
In healthy subjects, ceftaroline, ceftazidime and avibactam poorly distribute to CSF. Nonetheless, CSF exposure of both cephalosporins might be sufficient to cover certain, but not all, pathogens causative of CNS infections.
View article: Oral Ketamine for the Treatment of Depression: A randomized controlled trial and meta-analysis
Oral Ketamine for the Treatment of Depression: A randomized controlled trial and meta-analysis Open
Ketamine represents a significant advancement in antidepressant therapy, but the commonly used intravenous and intranasal application routes currently limit its availability beyond specialized centers. By contrast, oral ketamine treatment …
View article: The power of trapped ion mobility for isotope tracer experiments
The power of trapped ion mobility for isotope tracer experiments Open
By implementation of ion mobility, it is now possible to generate distinct isotopologue patterns for G1P and F6P in isotope tracer experiments. F6P plays a crucial role in glycolysis and PPP, highlighting the importance of precise analytic…
View article: Investigating a New Way to Assess Metabolic Risk in Pregnant Females with Prior RYGB Surgery
Investigating a New Way to Assess Metabolic Risk in Pregnant Females with Prior RYGB Surgery Open
Background: Obesity in pregnancy is linked to adverse clinical outcomes such as gestational diabetes. Recently, a risk score calculated by different ceramide concentrations was recognized as a new way to investigate cardiovascular risk. Th…
View article: Pharmacokinetics of isavuconazole at different target sites in healthy volunteers after single and multiple intravenous infusions
Pharmacokinetics of isavuconazole at different target sites in healthy volunteers after single and multiple intravenous infusions Open
Background Invasive aspergillosis is a severe fungal infection that affects multiple organ systems including the CNS and the lungs. Isavuconazole, a novel triazole antifungal agent, has demonstrated promising activity against Aspergillus s…
View article: The impact of biological sex in peripheral nerve blockade: A prospective pharmacodynamic, pharmacokinetic and morphometric study in volunteers
The impact of biological sex in peripheral nerve blockade: A prospective pharmacodynamic, pharmacokinetic and morphometric study in volunteers Open
Study objective The impact of biological sex in peripheral regional anaesthesia is largely unknown. We therefore designed a prospective study in volunteers to investigate the impact of biological sex on pharmacodynamic, pharmacokinetic and…
View article: Plasma and intraperitoneal pharmacokinetics of ceftazidime/avibactam in peritoneal dialysis patients
Plasma and intraperitoneal pharmacokinetics of ceftazidime/avibactam in peritoneal dialysis patients Open
On the basis of PTA simulations, a dose of 750/190 mg CAZ/AVI would be sufficient to treat plasma and peritoneal fluid infections in patients undergoing APD.
View article: Simvastatin therapy in higher dosages deteriorates bone quality: Consistent evidence from population-wide patient data and interventional mouse studies
Simvastatin therapy in higher dosages deteriorates bone quality: Consistent evidence from population-wide patient data and interventional mouse studies Open
High-dose simvastatin dramatically reduces bone quality in obese male and ovariectomized female mice, suggesting that direct drug action accounts for the association between high dosage and increased risk of osteoporosis as observed in com…
View article: Ethyl glucuronide in hair detects a high rate of harmful alcohol consumption in presumed non-alcoholic fatty liver disease
Ethyl glucuronide in hair detects a high rate of harmful alcohol consumption in presumed non-alcoholic fatty liver disease Open
Fatty liver disease can be caused by metabolic factors and/or alcohol consumption. The diagnosis of non-alcoholic fatty liver disease (NAFLD) is based on the exclusion of harmful alcohol consumption, while metabolic dysfunction-associated …
View article: The Effect of Pregabalin on the Minimum Alveolar Concentration of Sevoflurane: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial
The Effect of Pregabalin on the Minimum Alveolar Concentration of Sevoflurane: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial Open
Background Pregabalin is commonly used perioperatively to reduce post-operative pain and opioid consumption and to prevent the development of chronic pain. It has been shown to reduce anesthetic consumption in balanced anesthesia, but stud…
View article: Increased left dorsolateral prefrontal cortex density following escitalopram intake during relearning: a randomized, placebo-controlled trial in healthy humans
Increased left dorsolateral prefrontal cortex density following escitalopram intake during relearning: a randomized, placebo-controlled trial in healthy humans Open
Background: Serotonergic agents affect brain plasticity and reverse stress-induced dendritic atrophy in key fronto-limbic brain areas associated with learning and memory. Objectives: The aim of this study was to investigate effects of the …
View article: High Dose Lopinavir/Ritonavir Does Not Lead to Sufficient Plasma Levels to Inhibit SARS-CoV-2 in Hospitalized Patients With COVID-19
High Dose Lopinavir/Ritonavir Does Not Lead to Sufficient Plasma Levels to Inhibit SARS-CoV-2 in Hospitalized Patients With COVID-19 Open
Background: Despite lopinavir/ritonavir (LPV/RTV) demonstrating in-vitro activity against SARS-CoV-2, large trials failed to show any net clinical benefit. Since SARS-CoV-2 has an EC50 of 16.4 μg/ml for LPV this could be due to inadequate …
View article: In vivo / in vitro Correlation of Pharmacokinetics of Gentamicin, Vancomycin, Teicoplanin and Doripenem in a Bovine Blood Hemodialysis Model
In vivo / in vitro Correlation of Pharmacokinetics of Gentamicin, Vancomycin, Teicoplanin and Doripenem in a Bovine Blood Hemodialysis Model Open
Background: Elimination of a drug during renal replacement therapy is not only dependent on flow rates, molecular size and protein binding, but is often influenced by difficult to predict drug membrane interactions. In vitro models allow f…
View article: Effects of Escitalopram and Relearning on Cortical and Subcortical Grey Matter in Healthy Humans
Effects of Escitalopram and Relearning on Cortical and Subcortical Grey Matter in Healthy Humans Open
The antidepressant effect of selective serotonin reuptake inhibitors (SSRI) is related to increased neuroplasticity during relearning. Stress-induced dendritic atrophy in key brain areas for learning and memory such as the hippocampus and …
View article: Effect of Ketamine on Human Neurochemistry in Posterior Cingulate Cortex: A Pilot Magnetic Resonance Spectroscopy Study at 3 Tesla
Effect of Ketamine on Human Neurochemistry in Posterior Cingulate Cortex: A Pilot Magnetic Resonance Spectroscopy Study at 3 Tesla Open
Ketamine is a powerful glutamatergic long-lasting antidepressant, efficient in intractable major depression. Whereas ketamine’s immediate psychomimetic side-effects were linked to glutamate changes, proton MRS ( 1 H-MRS) showed an associat…
View article: Metabo-tip: a Metabolomics Platform for Lifestyle Monitoring
Metabo-tip: a Metabolomics Platform for Lifestyle Monitoring Open
Exposure to bioactive compounds from nutrition, pharmaceuticals, environmental contaminants or other lifestyle habits may affect the human organism. To gain insight into the effects of these influences, as well as the fundamental biochemic…