Thomas Tarnaud
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View article: Computational analysis of optogenetic inhibition of CA1 neurons using a data-efficient and interpretable potassium and chloride conducting opsin model
Computational analysis of optogenetic inhibition of CA1 neurons using a data-efficient and interpretable potassium and chloride conducting opsin model Open
Objective. Optogenetic inhibition of excitatory neuronal populations has emerged as a potential strategy for the treatment of refractory epilepsy. However, achieving effective seizure suppression in animal models using optogenetic techniqu…
View article: Locating activation sites of TMS with opposite current directions using probabilistic modelling and biophysical axon models
Locating activation sites of TMS with opposite current directions using probabilistic modelling and biophysical axon models Open
While a direct experimental confirmation of the activation sites is still needed, the results suggest that electric field analysis combined with tractography and biophysical axon modelling could be a useful computational tool for analysing…
View article: Numerical Study on Human Brain Cortical Electrostimulation Assessment During Uniform Magnetic Field Exposure at Intermediate Frequencies
Numerical Study on Human Brain Cortical Electrostimulation Assessment During Uniform Magnetic Field Exposure at Intermediate Frequencies Open
Objectives: Permissible limits have been established by international guidelines and standards for human protection to electromagnetic field exposure to prevent adverse health effects stemming from electrostimulation in the most sensitive …
View article: Numerical Study on Human Brain Cortical Electrostimulation Assessment During Uniform Magnetic Field Exposure at Intermediate Frequencies
Numerical Study on Human Brain Cortical Electrostimulation Assessment During Uniform Magnetic Field Exposure at Intermediate Frequencies Open
Permissible limits have been established by international guidelines and standards for human protection against electromagnetic field exposure to prevent adverse health effects stemming from electrostimulation in the most sensitive body pa…
View article: Action potential threshold variability for different electrostimulation models and its potential impact on occupational exposure limit values
Action potential threshold variability for different electrostimulation models and its potential impact on occupational exposure limit values Open
Occupational exposure limit values (ELVs) for body internal electric fields can be derived from thresholds for action potential generation. These thresholds can be calculated with electrostimulation models. The spatially extended nonlinear…
View article: Computational analysis of optogenetic inhibition of CA1 neurons using a data-efficient and interpretable potassium and chloride conducting opsin model
Computational analysis of optogenetic inhibition of CA1 neurons using a data-efficient and interpretable potassium and chloride conducting opsin model Open
Optogenetic inhibition of excitatory populations has been suggested as a novel technique for the treatment of refractory epilepsy. While this approach holds significant potential, achieving seizure suppression in animal models using optoge…
View article: Nonlinearities and timescales in neural models of temporal interference stimulation
Nonlinearities and timescales in neural models of temporal interference stimulation Open
In temporal interference (TI) stimulation, neuronal cells react to two interfering sinusoidal electric fields with a slightly different frequency (, in the range of about 1–4 kHz, in the range of about 1–100 Hz). It has been previously obs…
View article: Simulation study on high spatio-temporal resolution acousto-electrophysiological neuroimaging
Simulation study on high spatio-temporal resolution acousto-electrophysiological neuroimaging Open
Objective. Acousto-electrophysiological neuroimaging (AENI) is a technique hypothesized to record electrophysiological activity of the brain with millimeter spatial and sub-millisecond temporal resolution. This improvement is obtained by t…
View article: Quantitative analysis of the optogenetic excitability of CA1 neurons
Quantitative analysis of the optogenetic excitability of CA1 neurons Open
Introduction Optogenetics has emerged as a promising technique for modulating neuronal activity and holds potential for the treatment of neurological disorders such as temporal lobe epilepsy (TLE). However, clinical translation still faces…
View article: A Simulation Study on High Spatio-Temporal Resolution Acousto-Electrophysiological Neuroimaging
A Simulation Study on High Spatio-Temporal Resolution Acousto-Electrophysiological Neuroimaging Open
Acousto-electrophysiological neuroimaging is a technique hypothesized to record electrophysiological activity of the brain with millimeter spatial and sub-millisecond temporal resolution. This improvement is obtained by tagging areas with …
View article: Quantitative Analysis of the Optogenetic Excitability of CA1 Neurons
Quantitative Analysis of the Optogenetic Excitability of CA1 Neurons Open
Optogenetics has emerged as a promising technique for modulating neuronal activity and holds potential for the treatment of neurological disorders such as temporal lobe epilepsy (TLE). However, clinical translation still faces many challen…
View article: Influence of Temporal Interference Stimulation Parameters on Point Neuron Excitability
Influence of Temporal Interference Stimulation Parameters on Point Neuron Excitability Open
Temporal interference (TI) stimulation is a technique in which two high frequency sinusoidal electric fields, oscillating at a slightly different frequency are sent into the brain. The goal is to achieve stimulation at the place where both…
View article: Improved alpha-beta power reduction via combined electrical and ultrasonic stimulation in a parkinsonian cortex-basal ganglia-thalamus computational model
Improved alpha-beta power reduction via combined electrical and ultrasonic stimulation in a parkinsonian cortex-basal ganglia-thalamus computational model Open
Objective . To investigate computationally the interaction of combined electrical and ultrasonic modulation of isolated neurons and of the parkinsonian cortex-basal ganglia-thalamus loop. Approach . Continuous-wave or pulsed electrical and…
View article: Double Two-State Opsin Model With Autonomous Parameter Inference
Double Two-State Opsin Model With Autonomous Parameter Inference Open
Optogenetics has a lot of potential to become an effective neuromodulative therapy for clinical applications. Selecting the correct opsin is crucial to have an optimal optogenetic tool. With computational modeling, the neuronal response to…
View article: Membrane Charge Oscillations During Ultrasonic Neuromodulation by Intramembrane Cavitation
Membrane Charge Oscillations During Ultrasonic Neuromodulation by Intramembrane Cavitation Open
First steps are taken towards a morphologically realistic and computationally efficient UNMOD-model, improving our understanding of the underlying ultrasonic neuromodulation mechanisms.
View article: Improved alpha-beta power reduction via combined Electrical and Ultrasonic stimulation in a Parkinsonian Cortex-Basal Ganglia-Thalamus Computational Model
Improved alpha-beta power reduction via combined Electrical and Ultrasonic stimulation in a Parkinsonian Cortex-Basal Ganglia-Thalamus Computational Model Open
Objective To investigate computationally the interaction of combined electrical and ultrasonic modulation of isolated neurons and of the Parkinsonian cortex-basal ganglia-thalamus loop. Methods Continuous-wave or pulsed electrical and ultr…
View article: Hodgkin and Huxley Opsin Model for Computationally Efficient Optogenetic Neurostimulation in Cells and Networks
Hodgkin and Huxley Opsin Model for Computationally Efficient Optogenetic Neurostimulation in Cells and Networks Open
Optogenetics has a lot of potential to become an effective neuromodulative therapy for clinical application. Selecting the correct opsin is crucial to have an optimal optogenetic tool. With computational modeling, the neuronal response to …
View article: SECONIC: Towards multi-compartmental models for ultrasonic brain stimulation by intramembrane cavitation <sup>*</sup>
SECONIC: Towards multi-compartmental models for ultrasonic brain stimulation by intramembrane cavitation <sup>*</sup> Open
Objective . To design a computationally efficient model for ultrasonic neuromodulation (UNMOD) of morphologically realistic multi-compartmental neurons based on intramembrane cavitation. Approach . A Spatially Extended Neuronal Intramembra…
View article: Sensitivity Study of Neuronal Excitation and Cathodal Blocking Thresholds of Myelinated Axons for Percutaneous Auricular Vagus Nerve Stimulation
Sensitivity Study of Neuronal Excitation and Cathodal Blocking Thresholds of Myelinated Axons for Percutaneous Auricular Vagus Nerve Stimulation Open
Sensitivities of stimulation thresholds to these parameters by numerical simulation reveal how the stimulation parameters can be changed in order to increase therapeutic effect and comfort during pVNS by enabling more selective stimulation.
View article: Brain Cortical Stimulation Thresholds to Different Magnetic Field Sources Exposures at Intermediate Frequencies
Brain Cortical Stimulation Thresholds to Different Magnetic Field Sources Exposures at Intermediate Frequencies Open
Permissible field strengths in the international guidelines/standard for human protection are derived from peripheral nerve system stimulation at the intermediate frequencies where electrostimulation (attributable to axon activation) is mo…
View article: Current Directions in the Auricular Vagus Nerve Stimulation I – A Physiological Perspective
Current Directions in the Auricular Vagus Nerve Stimulation I – A Physiological Perspective Open
Electrical stimulation of the auricular vagus nerve (aVNS) is an emerging technology in the field of bioelectronic medicine with applications in therapy. Modulation of the afferent vagus nerve affects a large number of physiological proces…
View article: Current Directions in the Auricular Vagus Nerve Stimulation II – An Engineering Perspective
Current Directions in the Auricular Vagus Nerve Stimulation II – An Engineering Perspective Open
Electrical stimulation of the auricular vagus nerve (aVNS) is an emerging electroceutical technology in the field of bioelectronic medicine with applications in therapy. Artificial modulation of the afferent vagus nerve - a powerful entran…
View article: Setting Reference Level in Human Safety Guidelines via Cortical Nerve Activation Intercomparison at IF
Setting Reference Level in Human Safety Guidelines via Cortical Nerve Activation Intercomparison at IF Open
International guidelines/standards have been published for human protection from electromagnetic field exposure. The research in the intermediate frequencies (IF: 300 Hz-10 MHz) is scattered unlike for other frequencies, and thus the limit…
View article: Computational Modeling of Ultrasonic Subthalamic Nucleus Stimulation
Computational Modeling of Ultrasonic Subthalamic Nucleus Stimulation Open
Stimulation or suppresion of the STN is important in the treatment of Parkinson's disease, e.g., in deep brain stimulation. This explorative study on ultrasonic modulation of the STN, could be a step in the direction of minimally invasive …