Thomas Thymann
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View article: Hydrophobic drug particles adopt a complex biomolecular corona in ex vivo gastrointestinal fluids
Hydrophobic drug particles adopt a complex biomolecular corona in ex vivo gastrointestinal fluids Open
The adsorption of proteins and other biomolecules onto particles at the blood-particle interface, resulting in the formation of a biomolecular corona, is an established research area and can form the basis for a formulation concept to modi…
Chemostat culturing reduces fecal eukaryotic virus load and delays diarrhea after virome transplantation Open
Fecal virome transfer (FVT) shows promise in reducing necrotizing enterocolitis (NEC), likely due to donor bacteriophages preventing the gut dysbiosis preceding disease. However, concurrent transfer of eukaryotic viruses may carry a risk o…
Chemostat culturing reduces fecal eukaryotic virus load and delays diarrhea after virome transplantation Open
Fecal virome transfer (FVT) shows promise in reducing necrotizing enterocolitis (NEC), likely due to donor bacteriophages preventing the gut dysbiosis preceding disease. However, concurrent transfer of eukaryotic viruses may carry a risk o…
View article: Reduced parenteral glucose supply during neonatal infection attenuates neurological and renal pathology associated with modulation of innate and Th1 immunity
Reduced parenteral glucose supply during neonatal infection attenuates neurological and renal pathology associated with modulation of innate and Th1 immunity Open
Reduced glucose supply can reduce renal and neuro-inflammation during neonatal infection, thereby protecting brain and kidney health in infected preterm neonates.
View article: Postnatal enteral plasma supplementation following birth asphyxia increases fluid retention and kidney health in newborn pigs
Postnatal enteral plasma supplementation following birth asphyxia increases fluid retention and kidney health in newborn pigs Open
Birth asphyxia can result in kidney dysfunction, disturbances in systemic electrolytes and fluid balance in newborns. Currently, there is no proven dietary approach to support asphyxiated newborns. This study investigates whether oral plas…
Human milk improves the oral bioavailability of the poorly water-soluble drug clofazimine Open
Clofazimine is an emerging drug for the treatment of cryptosporidiosis in infants. As a poorly water-soluble drug, the formulation of clofazimine in age-appropriate vehicles is challenging and often results in the use of off-label formulat…
Chemostat culturing reduces fecal eukaryotic virus load and delays diarrhea after virome transplantation Open
Fecal virome transfer (FVT) shows promise in reducing necrotizing enterocolitis (NEC), likely due to donor bacteriophages preventing the gut dysbiosis preceding disease. However, concurrent transfer of eukaryotic viruses may carry a risk o…
Fecal virus-like particles are sufficient to reduce necrotizing enterocolitis Open
Fecal filtrate transfer (FFT) is emerging as a safer alternative to traditional fecal microbiota transplantation (FMT) - particularly in the context of necrotizing enterocolitis (NEC), a severe gastrointestinal condition affecting preterm …
Enteral plasma feeding improves gut function and immunity in piglets after birth asphyxia Open
Introduction Birth asphyxia may negatively affect gut function and immunity in newborns. Conversely, immunomodulatory milk diets may protect the gut and immune system against damage caused by asphyxia. Using caesarean-derived pigs as model…
View article: Reduced glucose supply during neonatal infection attenuates neurological and renal pathology via modulation of innate and Th1 immunity
Reduced glucose supply during neonatal infection attenuates neurological and renal pathology via modulation of innate and Th1 immunity Open
Background Premature infants are highly susceptible to infections that can lead to sepsis with life-threatening organ dysfunctions. The clinical practice of high parenteral glucose supply in preterm infants can exacerbate infection outcome…
Skeletal consequences of preterm birth in pigs as a model for preterm infants Open
Preterm birth affects about 10% of all live births with many resultant health challenges, including metabolic bone disease of prematurity (MBDP), which is characterized by elevated alkaline phosphatase, suppressed phosphate, and deficient …
A Gently Processed Skim Milk‐Derived Whey Protein Concentrate for Infant Formula: Effects on Gut Development and Immunity in Preterm Pigs Open
Scope Processing of whey protein concentrate (WPC) for infant formulas may induce protein modifications with severe consequences for preterm newborn development. The study investigates how conventional WPC and a gently processed skim milk‐…
Fecal virome is sufficient to reduce necrotizing enterocolitis Open
Background : Fecal filtrate transfer (FFT, i.e. “sterile filtered” fecal matter) is gaining increasing attention as a safer alternative to traditional fecal microbiota transplantation (FMT) for treating gastrointestinal (GI) complications.…
Gut development following insulin-like growth factor-1 supplementation to preterm pigs Open
Background Reduced insulin-like growth factor-1 (IGF-1) levels may contribute to impaired organ development in preterm infants. Using preterm pigs as a model, we hypothesized that IGF-1 supplementation improves health and gut development d…
Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health Open
Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig industry. Diarrhea and gut dysbiosis may in part be prevented via improved e…
View article: Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs
Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs Open
Introduction Preterm infants have increased risk of impaired neurodevelopment to which reduced systemic levels of insulin-like growth factor 1 (IGF-1) in the weeks after birth may play a role. Hence, we hypothesized that postnatal IGF-1 su…
Insulin-like Growth Factot-1 Supplementation Promotes Kidney Development and Alleviate Renal Inflammation in Preterm Pigs Open
Background Preterm birth and its associated complications cause disruption of normal prenatal renal development, leading to postnatal kidney injury and failure. Preterm infants are deficient in insulin-like growth factor 1 (IGF-1), a criti…
Ontogeny of CYP3A and UGT activity in preterm piglets: a translational model for drug metabolism in preterm newborns Open
Despite considerable progress in understanding drug metabolism in the human pediatric population, data remains scarce in preterm neonates. Improving our knowledge of the ADME properties in this vulnerable age group is of utmost importance …
View article: Insulin-Like Growth Factor-1 Supplementation Promotes Brain Maturation in Preterm Pigs
Insulin-Like Growth Factor-1 Supplementation Promotes Brain Maturation in Preterm Pigs Open
Very preterm infants show low levels of insulin-like growth factor-1 (IGF-1), which is associated with postnatal growth restriction and poor neurologic outcomes. It remains unknown whether supplemental IGF-1 may stimulate neurodevelopment …
Uncovering the gastrointestinal passage, intestinal epithelial cellular uptake, and AGO2 loading of milk miRNAs in neonates using xenomiRs as tracers Open
Milk-derived miRNAs survived GI passage in human and porcine neonates. Bovine-specific miRNAs accumulated in ICs of preterm piglets after enteral feeding with bovine colostrum/formula. In piglets, colostrum supplementation with cel-miR-39-…
Transplantation of fecal filtrate to neonatal pigs reduces post-weaning diarrhea: A pilot study Open
Post-weaning diarrhea (PWD) remains a major source of mortality and morbidity in swine production. Transplantation of bacteria-free filtrate of feces (fecal filtrate transplant, FFT) has shown gut protective effects in neonatal pigs, and e…
View article: Clinical outcome and gut development after insulin-like growth factor-1 supplementation to preterm pigs
Clinical outcome and gut development after insulin-like growth factor-1 supplementation to preterm pigs Open
Background Elevation of circulating insulin-like growth factor-1 (IGF-1) within normal physiological levels may alleviate several morbidities in preterm infants but safety and efficacy remain unclear. We hypothesized that IGF-1 supplementa…
View article: Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets
Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets Open
Infants with neonatal cholestasis are prone to neurodevelopmental deficits, however, the underlying pathogenesis is unclear. Lipid malabsorption and accumulation of potentially neurotoxic molecules in the blood such as bile acids are impor…
Donor-dependent fecal microbiota transplantation efficacy against necrotizing enterocolitis in preterm pigs Open
The development of necrotizing enterocolitis (NEC), a life-threatening inflammatory bowel disease affecting preterm infants, is connected with gut microbiota dysbiosis. Using preterm piglets as a model for preterm infants we recently showe…