Thomas Truelsen
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View article: Bilateral dynamic cerebral autoregulation assessment during endovascular treatment in large‐vessel occlusion stroke
Bilateral dynamic cerebral autoregulation assessment during endovascular treatment in large‐vessel occlusion stroke Open
Recanalization by endovascular treatment (EVT) is effective in acute ischaemic stroke caused by large‐vessel occlusion. Better understanding of the pathophysiology could possibly identify targets for improving peri‐procedural management an…
View article: Dynamic cerebral autoregulation during and 3 months after endovascular treatment in large vessel occlusion stroke
Dynamic cerebral autoregulation during and 3 months after endovascular treatment in large vessel occlusion stroke Open
Acute ischemic stroke caused by large vessel occlusion is effectively treated by endovascular treatment (EVT). However, treatment could be further refined by improved understanding of the pathophysiology, including dynamic cerebral autoreg…
View article: Accuracy of detecting critical findings using abbreviated brain MRI scan protocols as a prerequisite for AI-driven on-the-fly scan protocol adaptation
Accuracy of detecting critical findings using abbreviated brain MRI scan protocols as a prerequisite for AI-driven on-the-fly scan protocol adaptation Open
The initial steps towards automated real-time scan adaptation are feasible and can potentially improve detection sensitivity, balancing reduced specificities compared to the current standard of care.
View article: Evaluation of a volume and intensity-based FLAIR algorithm developed to assist in DWI-FLAIR mismatch assessment in wake-up stroke
Evaluation of a volume and intensity-based FLAIR algorithm developed to assist in DWI-FLAIR mismatch assessment in wake-up stroke Open
View article: Incidence and Prognosis of Pediatric Stroke in Denmark
Incidence and Prognosis of Pediatric Stroke in Denmark Open
From 2013 through 2020, the age-adjusted incidence rate of pediatric stroke increased in male individuals while remaining stable in female individuals. Morbidity and mortality after stroke were substantial, highlighting the need for furthe…
View article: Tenecteplase in Central Retinal Artery Occlusion Study (TenCRAOS): Protocol for a randomized-controlled trial
Tenecteplase in Central Retinal Artery Occlusion Study (TenCRAOS): Protocol for a randomized-controlled trial Open
Rationale: Central retinal artery occlusion (CRAO) is an ophthalmologic emergency that, without prompt reperfusion, is associated with a high risk of permanent blindness. There is currently no evidence-based, effective treatment for CRAO. …
View article: Cardiac Events After Mechanical Thrombectomy in Acute Ischemic Stroke: A Nation‐Wide Cohort Study
Cardiac Events After Mechanical Thrombectomy in Acute Ischemic Stroke: A Nation‐Wide Cohort Study Open
Introduction Mechanical thrombectomy (MT) markedly improves the outcome in patients with large vessel occlusion stroke. Given the cardiovascular risk profile of these patients, we wanted to investigate their post‐MT risk of cardiac events …
View article: Recurrence Rate in Children With Arterial Ischemic Stroke: A Systematic Review
Recurrence Rate in Children With Arterial Ischemic Stroke: A Systematic Review Open
Aim We conducted a systematic review to examine the recurrence rate in children with arterial ischemic stroke, including the recurrence rate according to stroke aetiology. Methods This systematic review was conducted in accordance with the…
View article: Platelet-Function-Monitoring-Guided Therapy After Emergent Carotid Artery Stenting
Platelet-Function-Monitoring-Guided Therapy After Emergent Carotid Artery Stenting Open
Background/Objectives: Antiplatelet therapy after emergent carotid stenting (eCAS) represents a challenge in balancing the risk of intracerebral hemorrhages (ICHs) and in-stent thrombosis (IST). Post-procedural platelet function monitoring…
View article: External validation of clinical risk prediction score for elderly treated with endovascular thrombectomy
External validation of clinical risk prediction score for elderly treated with endovascular thrombectomy Open
View article: Outcome and safety of mechanical thrombectomy in patients with acute ischemic stroke due to internal carotid artery dissection
Outcome and safety of mechanical thrombectomy in patients with acute ischemic stroke due to internal carotid artery dissection Open
Background Mechanical thrombectomy (MT) in patients with symptoms of acute ischemic stroke (AIS) due to internal carotid artery dissection (ICAD) remains controversial. In this study, we present clinical outcome and safety of MT in acute I…
View article: Outcome of Pediatric Large Vessel Occlusion Stroke in Denmark
Outcome of Pediatric Large Vessel Occlusion Stroke in Denmark Open
Background We performed a nationwide study to examine clinical outcome in children with large‐vessel occlusion (LVO) stroke treated with mechanical thrombectomy (MT) or conservatively. Methods Study participants were enrolled by 2 methods:…
View article: Trials of endovascular thrombectomy of basilar-artery occlusion compared to real-life data
Trials of endovascular thrombectomy of basilar-artery occlusion compared to real-life data Open
Outcome of MT in BAO stroke in a clinical patient cohort was similar to recent trials, despite broader patient inclusion and differences in both occluded BAO segment and use of stenting. Our study suggest that MT is safe and effective in a…
View article: Long-term stroke risk in Moyamoya disease
Long-term stroke risk in Moyamoya disease Open
Background: Moyamoya disease (MMD) is considered a progressive disease with an ongoing risk of recurrent stroke. However, there is a lack of long-term observational data to quantify the extent of the stroke risk. Methods: This study aimed …
View article: Usability and feasibility of PreventS-MD web app for stroke prevention
Usability and feasibility of PreventS-MD web app for stroke prevention Open
Background: Most strokes and cardiovascular diseases (CVDs) are potentially preventable if their risk factors are identified and well controlled. Digital platforms, such as the PreventS-MD web app (PreventS-MD) may aid health care professi…
View article: Artificial Intelligence for Automated DWI/FLAIR Mismatch Assessment on Magnetic Resonance Imaging in Stroke: A Systematic Review
Artificial Intelligence for Automated DWI/FLAIR Mismatch Assessment on Magnetic Resonance Imaging in Stroke: A Systematic Review Open
We conducted this Systematic Review to create an overview of the currently existing Artificial Intelligence (AI) methods for Magnetic Resonance Diffusion-Weighted Imaging (DWI)/Fluid-Attenuated Inversion Recovery (FLAIR)—mismatch assessmen…
View article: The Positive Predictive Value of Pediatric Stroke Diagnoses in Administrative Data: A Retrospective Validation Study
The Positive Predictive Value of Pediatric Stroke Diagnoses in Administrative Data: A Retrospective Validation Study Open
After validation, stroke was confirmed in only half of the children registered in the DNRP with a stroke-specific diagnosis. Non-validated administrative data should be used with caution in pediatric stroke research. Pediatric stroke incid…
View article: Acute triage of childhood stroke in Denmark
Acute triage of childhood stroke in Denmark Open
Objective: This 2-year observational study aimed to test the feasibility of implementing a pediatric stroke triage-setup that connected frontline providers with vascular neurologists and to examine final diagnoses in children triaged for s…
View article: Response-monitored dual anti-platelet treatment in a patient with spontaneous post-partum four-vessel cervical artery dissection
Response-monitored dual anti-platelet treatment in a patient with spontaneous post-partum four-vessel cervical artery dissection Open
View article: Mechanical thrombectomy in stroke patients of advanced age with score-based prediction of outcome
Mechanical thrombectomy in stroke patients of advanced age with score-based prediction of outcome Open
Background Stroke patients ≥80 years constituted only 15% in randomised trials on mechanical thrombectomy (MT), but is a considerable higher proportion in clinical practice. Association of clinical variables collected before MT with functi…
View article: Reducing delay to endovascular reperfusion after relocating a thrombolysis unit
Reducing delay to endovascular reperfusion after relocating a thrombolysis unit Open
Background and aims Functional outcome following mechanical thrombectomy (MT) in patients with acute ischemic stroke and large vessel occlusion is time-dependent and worsens with increasing delay. Time to endovascular reperfusion is potent…
View article: Automated Identification of Multiple Findings on Brain MRI for Improving Scan Acquisition and Interpretation Workflows: A Systematic Review
Automated Identification of Multiple Findings on Brain MRI for Improving Scan Acquisition and Interpretation Workflows: A Systematic Review Open
We conducted a systematic review of the current status of machine learning (ML) algorithms’ ability to identify multiple brain diseases, and we evaluated their applicability for improving existing scan acquisition and interpretation workfl…
View article: Randomized Trial of Surgical Left Atrial Appendage Closure: Protection Against Cerebrovascular Events
Randomized Trial of Surgical Left Atrial Appendage Closure: Protection Against Cerebrovascular Events Open
Following open-heart surgery, atrial fibrillation and stroke occur frequently. Left atrial appendage closure added to elective open-heart surgery could reduce the risk of ischemic stroke. We aim to examine if routine closure of the left at…
View article: Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage—A Systematic Review
Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage—A Systematic Review Open
Previous studies suggest that the most common cause of spontaneous intracerebral hemorrhage in children and adolescents is arteriovenous malformations (AVMs). However, an update containing recently published data on pediatric spontaneous i…
View article: Effects of Semaglutide on Stroke Subtypes in Type 2 Diabetes: Post Hoc Analysis of the Randomized SUSTAIN 6 and PIONEER 6
Effects of Semaglutide on Stroke Subtypes in Type 2 Diabetes: Post Hoc Analysis of the Randomized SUSTAIN 6 and PIONEER 6 Open
Background: GLP-1 RA (glucagon-like peptide-1 receptor agonists), including semaglutide, may reduce stroke risk in people with type 2 diabetes. This post hoc analysis examined the subcutaneous and oral semaglutide effects, versus placebo, …
View article: Supplementary Material for: Predictive Value of Pediatric Stroke Diagnoses in Administrative Data: A Systematic Literature Review
Supplementary Material for: Predictive Value of Pediatric Stroke Diagnoses in Administrative Data: A Systematic Literature Review Open
Background and aim Administrative healthcare data are frequently used for studying incidence, prevalence, risk factors and outcome of pediatric stroke. However, the accuracy of these data sources is uncertain. The aim of this study was to …
View article: Stroke admissions and revascularization treatments in Denmark during COVID‐19
Stroke admissions and revascularization treatments in Denmark during COVID‐19 Open
OBJECTIVE: The aim of this study was to assess the number of stroke‐related admissions and acute treatments during the first two waves of COVID‐19 and lockdowns in the Capital Region of Denmark and the Region of Zealand. MATERIALS & METHOD…
View article: Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 Open
View article: Atrial fibrillation in cryptogenic stroke and transient ischaemic attack – The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study: Rationale and design
Atrial fibrillation in cryptogenic stroke and transient ischaemic attack – The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study: Rationale and design Open
Purpose Paroxysmal atrial fibrillation is often suspected as a probable cause of cryptogenic stroke. Continuous long-term ECG monitoring using insertable cardiac monitors is a clinically effective technique to screen for atrial fibrillatio…
View article: Acute endovascular reperfusion treatment in patients with ischaemic stroke and large‐vessel occlusion (Denmark 2011–2017)
Acute endovascular reperfusion treatment in patients with ischaemic stroke and large‐vessel occlusion (Denmark 2011–2017) Open
Background and purpose Acute endovascular reperfusion treatment (aERT) of stroke patients with large‐vessel occlusions is efficacious and safe according to several clinical trials. Data on outcome and safety of aERT in daily clinical routi…