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View article: Combination of Orai1 inhibitor CM5480 with specific therapy mitigates pulmonary hypertension and its cardiac dysfunction
Combination of Orai1 inhibitor CM5480 with specific therapy mitigates pulmonary hypertension and its cardiac dysfunction Open
Pulmonary arterial hypertension (PAH) is a rare and incurable disease characterized by progressive narrowing of pulmonary arteries (PA), resulting in right ventricular (RV) hypertrophy, RV failure, and eventually death. Orai1 inhibition ha…
View article: Sleeve Resection With or Without Parenchymal Resection for Proximal Bronchial Carcinoids: A Retrospective Analysis of Recurrence and Lymph Node Involvement
Sleeve Resection With or Without Parenchymal Resection for Proximal Bronchial Carcinoids: A Retrospective Analysis of Recurrence and Lymph Node Involvement Open
Objectives Risk factors of recurrence in sleeve resection for endobronchial carcinoid tumours are well known. However, the impact of parenchymal sparing has not been studied. This study aims to determine whether associated parenchymal remo…
View article: A Specific Methylation Class Identifies BAP1‐Deficient Meningiomas, Including Meningeal Tumours With Poorly Differentiated Nonrhabdoid Histology
A Specific Methylation Class Identifies BAP1‐Deficient Meningiomas, Including Meningeal Tumours With Poorly Differentiated Nonrhabdoid Histology Open
Summary Undifferentiated cytokeratin‐expressing non rhabdoid meningeal tumor can correspond to BAP1 ‐deficient meningiomas. DNA methylation profiling identifies a methylation class specific to BAP1 ‐deficient meningioma. BAP1 ‐deficient me…
View article: A clinically relevant morpho-molecular classification of lung neuroendocrine tumours
A clinically relevant morpho-molecular classification of lung neuroendocrine tumours Open
Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. We conducted multi-omic analyses on over 300 lung NETs includ…
View article: Platelet aggregates in lung capillaries in severely decompensated pulmonary hypertension
Platelet aggregates in lung capillaries in severely decompensated pulmonary hypertension Open
The mechanism of thrombocytopenia during acute pulmonary hypertension (PH) decompensation may be partly due to platelet aggregation in the lung. Platelet aggregates in explanted lung from 16 lung transplant patients during acute PH decompe…
View article: <i>TERT</i> Expression and Clinical Outcome in Pulmonary Carcinoids
<i>TERT</i> Expression and Clinical Outcome in Pulmonary Carcinoids Open
PURPOSE The clinical course of pulmonary carcinoids ranges from indolent to fatal disease, suggesting that specific molecular alterations drive progression toward the fully malignant state. A similar spectrum of clinical phenotypes occurs …
View article: <scp>DNA</scp> methylation as a new tool for the differential diagnosis between T‐<scp>LBL</scp> and lymphocyte‐rich thymoma
<span>DNA</span> methylation as a new tool for the differential diagnosis between T‐<span>LBL</span> and lymphocyte‐rich thymoma Open
T‐lymphoblastic lymphoma (T‐LBL) and thymoma are two rare primary tumors of the thymus deriving either from T‐cell precursors or from thymic epithelial cells, respectively. Some thymoma subtypes (AB, B1, and B2) display numerous reactive t…
View article: Doppler echocardiography for surveillance of acute cardiac allograft rejection: a 28-year single-center experience
Doppler echocardiography for surveillance of acute cardiac allograft rejection: a 28-year single-center experience Open
Doppler echocardiography as a first-line method for surveillance of ACR did not impair long-term results after HT. These findings suggest that this non-invasive approach might be a reasonable alternative to systematic EMB, limiting risk an…
View article: International reproducibility study of thymic epithelial tumors staging: pT stage is an issue. proposals for improvement. A RYTHMIC/ITMIG study
International reproducibility study of thymic epithelial tumors staging: pT stage is an issue. proposals for improvement. A RYTHMIC/ITMIG study Open
Our study underlines that the evaluation of the pT stage of TET is problematic and needs to be addressed in more detail in an upcoming TNM classification. The publication of histopathologic images of landmarks, including ancillary tests co…
View article: AB004. Basaloid carcinoma of the thymus: experience of the RYTHMIC network over an 8-year period
AB004. Basaloid carcinoma of the thymus: experience of the RYTHMIC network over an 8-year period Open
BACKGROUND: Basaloid carcinoma of the thymus is a well-defined but rare entity. The French RYTHMIC network is dedicated to the management of patients with thymic epithelial tumors, organizing an expert review for each included case. METHOD…
View article: Immune Checkpoints are Predominantly Co-Expressed by Clonally Expanded CD4+FoxP3+ Intratumoral T-cells in Primary Human Cancers
Immune Checkpoints are Predominantly Co-Expressed by Clonally Expanded CD4+FoxP3+ Intratumoral T-cells in Primary Human Cancers Open
Background. Besides anti-PD(L)1, anti-CTLA-4 and anti-LAG-3, novel immune checkpoint proteins (ICP)-targeted antibodies have recently failed to demonstrate significant efficacy in clinical trials. In those trials, patients were enrolled wi…
View article: Data from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Data from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment Open
Homing of CD8+ T lymphocytes to the tumor microenvironment is an important step for mounting a robust antitumor immune response. TGFβ is responsible for CD103 (αEβ7) integrin induction in activated intraepithelial CD8+ T lymphocytes. Howev…
View article: CTL CD103+ on rE-cadh-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
CTL CD103+ on rE-cadh-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment Open
CTL CD103+ on rE-cadh-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
View article: Supplementary Figure and Movie Legend from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Supplementary Figure and Movie Legend from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment Open
Legend for Supplementary Figures S1-S5 and Supplementary Movies.
View article: CTL CD103+ on rICAM-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
CTL CD103+ on rICAM-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment Open
CTL CD103+ on rICAM-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
View article: CTL CD103+ treated TGF-β on r-Ecadh-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
CTL CD103+ treated TGF-β on r-Ecadh-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment Open
CTL CD103+ treated TGF-β on r-Ecadh-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
View article: Supplementary Figures S1-S5 from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Supplementary Figures S1-S5 from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment Open
Effects of chemokines and TGF-B on T-cell adhesion to recombinant molecules and specific tumor cells (S1); Influence of TGF-B and chemokines on integrin expression and T-cell motility (S2); Tumor slice staining, influence of anti-CD103 on …
View article: Supplementary Tables S1-S3 from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Supplementary Tables S1-S3 from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment Open
Statistical analyses of results shown in Figure 1A (S1); Statistical analyses of results shown in Supplementary Figure 1A (S2); Statistical analyses of results shown in Supplementary Figure 2B (S3).
View article: CTL CD103+ treated TGF-β on rICAM-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
CTL CD103+ treated TGF-β on rICAM-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment Open
CTL CD103+ treated TGF-β on rICAM-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
View article: Supplementary Figures S1-S5 from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Supplementary Figures S1-S5 from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment Open
Effects of chemokines and TGF-B on T-cell adhesion to recombinant molecules and specific tumor cells (S1); Influence of TGF-B and chemokines on integrin expression and T-cell motility (S2); Tumor slice staining, influence of anti-CD103 on …