Explanipedia

Light-Activated Metal-Dependent Protein Degradation: A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1 Open

Lars Stevens‐Cullinane, Thomas W. Rees, C. A. Evans, Po‐Yu Ho, Mika Kintzel , et al. · 2025

Antimicrobial resistance (AMR) is a global health threat, yet, despite this, antibiotic drug discovery has stagnated. Most compounds entering the clinic represent already discovered classes, to which bacteria already display resistance. We…

Light-Activated Metal-dependent Protein Degradation (LAMP-D): A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1 Open

Lars Stevens‐Cullinane, Thomas W. Rees, C. A. Evans, Po‐Yu Ho, Mika Kintzel , et al. · 2025

The growth of antimicrobial resistance (AMR) is a significant global health threat, yet despite this alarming trend, antibiotic drug discovery has significantly slowed. Most compounds entering the clinic represent already discovered classe…

Fluid Topology Optimization of Film Cooling: a Design Exploration Open

Francesco Montomoli, Thomas W. Rees, Stefano Furino, Ruben Tomlin · 2025

Antibacterial activity of Au(I), Pt(II), and Ir(III) biotin conjugates prepared by the iClick reaction: influence of the metal coordination sphere on the biological activity Open

Dominik Moreth, Lars Stevens‐Cullinane, Thomas W. Rees, Victoria V. L. Müller, A. Du Pasquier , et al. · 2024

Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases Open

Yaoyu Ding, Edward Lambden, Jessica Peate, Lewis J. Picken, Thomas W. Rees , et al. · 2024

Nonribosomal cyclic peptides (NRcPs) are structurally complex natural products and a vital pool of therapeutics, particularly antibiotics. Their structural diversity arises from the ability of the multidomain enzyme assembly lines, nonribo…

Recent Advances in Metal Complexes for Antimicrobial Photodynamic Therapy Open

Thomas W. Rees, Po‐Yu Ho, Jeannine Hess · 2023

Antimicrobial resistance (AMR) is a growing global problem with more than 1 million deaths due to AMR infection in 2019 alone. New and innovative therapeutics are required to overcome this challenge. Antimicrobial photodynamic therapy (aPD…

CCDC 1882766: Experimental Crystal Structure Determination Open

Cheng Ouyang, Yongguang Li, Thomas W. Rees, Xinxing Liao, Jian‐Hua Jia , et al. · 2020

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1941709: Experimental Crystal Structure Determination Open

Kai Xiong, Qianwang Chen, Yi‐Xian Yuan, Wei Lin, Xinxing Liao , et al. · 2020

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1941706: Experimental Crystal Structure Determination Open

Kai Xiong, Qian Chen, Yi‐Xian Yuan, Wei Lin, Xinxing Liao , et al. · 2020

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1941708: Experimental Crystal Structure Determination Open

Kai Xiong, Qian Chen, Yi‐Xian Yuan, Lin Wei, Xinxing Liao , et al. · 2020

CCDC 1941705: Experimental Crystal Structure Determination Open

Kai Xiong, Chen Qian, Yi‐Xian Yuan, Wei Lin, Xinxing Liao , et al. · 2020

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1941707: Experimental Crystal Structure Determination Open

Kai Xiong, Qian Chen, Yi‐Xian Yuan, Wei Lin, Xinxing Liao , et al. · 2020

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1892727: Experimental Crystal Structure Determination Open

Ya Wen, Cheng Ouyang, Quan-Wen Li, Thomas W. Rees, Kangqiang Qiu , et al. · 2020

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1892728: Experimental Crystal Structure Determination Open

Ya Wen, Cheng Ouyang, Quan-Wen Li, Thomas W. Rees, Kangqiang Qiu , et al. · 2020

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 2003973: Experimental Crystal Structure Determination Open

Ya Wen, Cheng Ouyang, Quan-Wen Li, Thomas W. Rees, Kangqiang Qiu , et al. · 2020

CCDC 2003972: Experimental Crystal Structure Determination Open

Ya Wen, Cheng Ouyang, Quan-Wen Li, Thomas W. Rees, Kangqiang Qiu , et al. · 2020

CCDC 1892729: Experimental Crystal Structure Determination Open

Ya Wen, Cheng Ouyang, Quan-Wen Li, Thomas W. Rees, Kangqiang Qiu , et al. · 2020

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 2003974: Experimental Crystal Structure Determination Open

Ya Wen, Cheng Ouyang, Quan-Wen Li, Thomas W. Rees, Kangqiang Qiu , et al. · 2020

CCDC 2003975: Experimental Crystal Structure Determination Open

Ya Wen, Cheng Ouyang, Quan-Wen Li, Thomas W. Rees, Kangqiang Qiu , et al. · 2020

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1888122: Experimental Crystal Structure Determination Open

Bole Yu, Thomas W. Rees, Jiewen Liang, Chengzhi Jin, Yu Chen , et al. · 2020

Correction: Fabrication of red blood cell membrane-camouflaged Cu2−xSe nanoparticles for phototherapy in the second near-infrared window Open

Zhou Liu, Jinquan Wang, Kangqiang Qiu, Xinxing Liao, Thomas W. Rees , et al. · 2020

Correction for ‘Fabrication of red blood cell membrane-camouflaged Cu_2−xSe nanoparticles for phototherapy in the second near-infrared window’ by Zhou Liu et al., Chem. Commun., 2019, 55, 6523–6526.

Correction: Mitochondria-targeted Ir@AuNRs as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy Open

Libing Ke, Cheng Zhang, Xinxing Liao, Kangqiang Qiu, Thomas W. Rees , et al. · 2020

Correction for ‘Mitochondria-targeted Ir@AuNRs as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy’ by Libing Ke et al., Chem. Commun., 2019, 55, 10273–10276.

Correction: Synthesis, characterization and anticancer mechanism studies of fluorinated cyclometalated ruthenium(ii) complexes Open

Ya Wen, Cheng Ouyang, Quanwen Li, Thomas W. Rees, Kangqiang Qiu , et al. · 2020

Correction for ‘Synthesis, characterization and anticancer mechanism studies of fluorinated cyclometalated ruthenium(ii) complexes’ by Ya Wen et al., Dalton Trans., 2020, DOI: 10.1039/d0dt01412e.

A self-assembled Ru–Pt metallacage as a lysosome-targeting photosensitizer for 2-photon photodynamic therapy Open

Zhixuan Zhou, Jiangping Liu, Juanjuan Huang, Thomas W. Rees, Yiliang Wang , et al. · 2019

Significance Photodynamic therapy (PDT) is an emerging treatment method for various types of diseases. In PDT, photosensitizers absorb light of appropriate energy and then convert oxygen into highly reactive oxygen species that destroy mal…

Capturing the interplay between spin–orbit coupling and non-Condon effects on the photoabsorption spectra of Ru and Os dyes Open

Theo Keane, Thomas W. Rees, Etienne Baranoff, Basile F. E. Curchod · 2019

A theoretical protocol developed to study the low-energy tail of the absorption spectrum of homoleptic biscyclometalated ruthenium and osmium complexes.

Heterometallic Ru–Pt metallacycle for two-photon photodynamic therapy Open

Zhixuan Zhou, Jiangping Liu, Thomas W. Rees, Heng Wang, Xiaopeng Li , et al. · 2018

Significance Photodynamic therapy is a noninvasive medical procedure in which malignant tissue is damaged by reactive oxygen species generated from targeted light irradiation on a photosensitizer. Herein, we incorporate an Ru(II)-based two…

Oncosis-inducing cyclometalated iridium(iii) complexes Open

Ruilin Guan, Yu Chen, Leli Zeng, Thomas W. Rees, Chengzhi Jin , et al. · 2018

A series of mitochondria-targeting cyclometalated iridium(iii) complexes activated the oncosis-specific protein porimin and calpain 1, and exhibited good inhibitory activities on a wide range of cancer types including drug-resistant cancer…

CCDC 1578910: Experimental Crystal Structure Determination Open

Ruilin Guan, Yu Chen, Leli Zeng, Thomas W. Rees, Chengzhi Jin , et al. · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Synthesis and Characterization of a Series of Bis-homoleptic Cycloruthenates with Terdentate Ligands as a Family of Panchromatic Dyes Open

Thomas W. Rees, Jin‐Feng Liao, Alessandro Sinopoli, Louise Male, Giuseppe Calogero , et al. · 2017

A series of six homoleptic bis-cyclometalated ruthenium complexes, Ru(N^N^C)₂, is reported where N^N^C is a 6-(2,4-difluoro-3-R³-phenyl)-4-R²-4'-R¹-2,2'-bipyridine with R³ = -H or -CF<…

Bis-homoleptic, Terdentate, Cyclometalates of Group 8 and 9 Open

Thomas W. Rees · 2017

Cyclometalates have been the focus of much attention in recent years and have applications ranging from photovoltaics to cancer therapies. Many heteroleptic terdentate complexes are known in the literature however bis-homoleptic terdentate…

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